Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities

Ping, Zhaohua; Liu, Ting; Xu, Hui; Meng, Yan; Li, Wenhua; Xu, Xiaojuan; Zhang, Lina

doi:10.1007/s12274-017-1590-7

Cited by 58 publications

(34 citation statements)

References 50 publications

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“…These toxicities can be prevented by conjugating anastrozole with SeNPs 155,156 . Similarly, SeNPs prepared using highly branched β-(1-3)-D-glucan obtained from fruiting plants of auricularia auricular-judae (AF1-Se) showed strong suppression against human breast adenocarcinoma cancer cell lines such as MCF-7, MDA-MB-468, and MDAMB-231 157 . SeNPs decorated using various polysaccharides extracted from pleurotus tuberregium (PTR), ganoderma lucidum (GL), coriolus versicolor (CV), and polyporus rhinoceros (PR) showed highest activity for gastric cancer cell lines AGS 158 .…”

Section: Materials Advances Accepted Manuscriptmentioning

confidence: 99%

Selenium nanoparticles: a review on synthesis and biomedical applications

2022

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Section: Materials Advances Accepted Manuscriptmentioning

confidence: 99%

Selenium nanoparticles: a review on synthesis and biomedical applications

2022

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“…Therefore, the fluorescence intensity of C6‐loaded DNT‐Au (DNT‐Au‐C6) in cells was measured to quantitatively analyze the cell absorption of DNT‐Au. In the present work, C6 was added into the system before the synthesis of AuNPs, and C6 would be loaded into the hollow space of DNTs due to hydrophilic and hydrophobic interaction 28 . As shown in Figure 9b, flow cytometry was used to detect the absorption of DNT‐Au‐C6 at different time points.…”

Section: Resultsmentioning

confidence: 99%

“…To investigate the cellular uptake behaviors of DNT‐Au in vitro, C6 loaded DNTs were prepared according to the previous study 28 . In the present work, C6 was added into the system before the synthesis of AuNPs.…”

Section: Methodsmentioning

confidence: 99%

Construction of gold nanoparticles by tubular polysaccharide from black fungus and their apoptosis‐inducing activities in HepG2 cells

Song

Gao

et al. 2021

J of Applied Polymer Sci

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Gold nanoparticles (AuNPs) with size of 12 ~ 25 nm were loaded on the dendritic nanotubes (DNTs), which were self‐assembled by the triple‐helix polysaccharides from black fungus (AF1). The characterization results proved that the AuNPs were dispersed on the surface of DNTs without affecting their tubular structure. Due to the dendritic structure, the loading content of AuNPs could arrived at 46.4%. Moreover, the potential anticancer activities of the complex (DNT‐Au) were evaluated by the induction of apoptosis in HepG2 cells. It was found DNT‐Au could be taken up by cells and enter into lysosomes, further inducing apoptosis in HepG2 cells by ROS‐mediated mitochondrial dysfunction. This work was benefit for the development of natural polysaccharide as a substrate to stabilize nanoparticles in biomedical fields.

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“…However, selenium in the form of nanoparticles is unstable and easily transformed into an inactive form [289], which necessitates the use of stabilizing agents in SeNPs solutions. These solutions may be stabilized and modified by various polymers, such as chitosan [290,291] and other polysaccharides [44,45,[292][293][294][295][296][297], proteins [293,294], or their combinations [298][299][300].…”

Section: Polysaccharide Encapsulated Nanoseleniummentioning

confidence: 99%

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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Selenosugars are a group of sugar derivatives of great structural diversity (e.g., molar masses, selenium oxidation state, and selenium binding), obtained as a result of biosynthesis, chemical modification of natural compounds, or chemical synthesis. Seleno-monosaccharides and disaccharides are known to be non-toxic products of the natural metabolism of selenium compounds in mammals. In the case of the selenium-containing polysaccharides of natural origin, their formation is also postulated as a form of detoxification of excess selenium in microorganisms, mushroom, and plants. The valency of selenium in selenium-containing polysaccharides can be: 0 (encapsulated nano-selenium), IV (selenites of polysaccharides), or II (selenoglycosides or selenium built into the sugar ring to replace oxygen). The great interest in Se-polysaccharides results from the expected synergy between selenium and polysaccharides. Several plant- and mushroom-derived polysaccharides are potent macromolecules with antitumor, immunomodulatory, antioxidant, and other biological properties. Selenium, a trace element of fundamental importance to human health, has been shown to possess several analogous functions. The mechanism by which selenium exerts anticancer and immunomodulatory activity differs from that of polysaccharide fractions, but a similar pharmacological effect suggests a possible synergy of these two agents. Various functions of Se-polysaccharides have been explored, including antitumor, immune-enhancement, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, and neuroprotective activities. Due to being non-toxic or much less toxic than inorganic selenium compounds, Se-polysaccharides are potential dietary supplements that could be used, e.g., in chemoprevention.

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Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities

Cited by 58 publications

References 50 publications

Selenium nanoparticles: a review on synthesis and biomedical applications

Selenium nanoparticles: a review on synthesis and biomedical applications

Construction of gold nanoparticles by tubular polysaccharide from black fungus and their apoptosis‐inducing activities in HepG2 cells

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

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