Construction of hyperbranched polysiloxane-based multifunctional fluorescent prodrug for preferential cellular uptake and dual-responsive drug release

Zhao, Yan; Liu, Biao; Lou, Rui; Qi, Yibo; He, Miaomiao; Long, Sihao; Feng, Weixu; Yan, Hongxia

doi:10.1016/j.bioadv.2022.212848

Cited by 11 publications

(17 citation statements)

References 53 publications

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“…The zeta potential of CSL@MI 7 -β-CD/SA NPs was −25.9 mV lower than that of MI 7 -β-CD/SA NPs at −12.3 mV, which may be attributed to the fact that a small portion of CSL was adsorbed on the surface of MI 7 -β-CD/SA NPs during the uploading of CSL. The results also indicated that CSL@MI 7 -β-CD/SA NPs with a negative potential could potentially prolong the blood circulation time and enhance the potential of penetrating tumor cell membranes. , 2D NOESY 1 H NMR was generally used to investigate the resonance signals of protons. A significant nuclear supercharge effect can be exhibited when two protons in a molecule are adjacent to each other within a short distance.…”

Section: Resultsmentioning

confidence: 99%

“…The results also indicated that CSL@MI 7 -β-CD/SA NPs with a negative potential could potentially prolong the blood circulation time and enhance the potential of penetrating tumor cell membranes. 34,35 2D NOESY 1 H NMR was generally used to investigate the resonance signals of protons. A significant nuclear supercharge effect can be exhibited when two protons in a molecule are adjacent to each other within a short distance.…”

Section: ■ Introductionmentioning

confidence: 99%

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pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound

Chen,

Zhu,

Nie

et al. 2023

Langmuir

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Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound

Chen,

Zhu,

Nie

et al. 2023

Langmuir

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“…[ 7 ] Among all the reported hyperbranched polymers, hyperbranched polysiloxane (HBPSi) has appealed to extensive interests in recent years owing to its excellent fluorescence property and biocompatibility. [ 8‐10 ] In addition, the one‐step synthesis, easy modification, as well as costless preparation process also make it suitable for large‐scale industrial production. Therefore, the development of novel fluorescence HBPSi with customizable fluorescence properties has become a new research hotspot.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Eu³⁺ Coordinated Hyperbranched Polysiloxane with Multicolor Emission and Long Fluorescence Lifetime^†

Feng

Yan

et al. 2023

Chin. J. Chem.

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Comprehensive Summary Hyperbranched polysiloxanes have attracted increasing interest due to their unique fluorescence properties. However, the relatively short emission wavelength and low fluorescence lifetime are still the main obstacles to their broader application. In this study, we first synthesized a β‐diketone contained hyperbranched polysiloxane with excitation‐dependent multicolor emission. Further through the coordination of HBPSi‐NMDEA with Eu3+ ion, a hybrid luminescent material was prepared. It exhibited not only aggregation‐induced red emission at 613 nm, but also a long fluorescence lifetime of 681.45 μs. Particularly, it showed highly sensitive reversible fluorescence response to temperature variation, thus displaying the potential to be used in fluorescence temperature detection.

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“…Very recently, Zhao and others constructed a hyperbranched multifunctional prodrug (HBPSi-SS-HCPT) based on the nonconventional aggregation-induced emission (AIE) feature of hyperbranched polysiloxanes (HBPSi). 132 The anticancer drug 10-hydroxycamptothecin (HCPT) was covalently grafted on the HBPSi using 3,3-dithiodipropionic acid as the linker to afford HBPSi-SS-HCPT. The ester and disulfide bonds render HBPSi-SS-HCPT pH/redox dual-responsiveness.…”

Section: Dual-responsive Polymersmentioning

confidence: 99%

Stimuli-Responsive Aggregation-Induced Emission (AIE)-Active Polymers for Biomedical Applications

Chowdhury

Banerjee

Saha

et al. 2022

ACS Biomater. Sci. Eng.

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At high concentration or in the aggregated state, most of the traditional luminophores suffer from the general aggregation-caused quenching (ACQ) effect, which significantly limits their biomedical applications. On the contrary, a few fluorophores exhibit an aggregation-induced emission (AIE) feature which is just the opposite of ACQ. The luminophores with aggregation-induced emission (AIEgens) have exhibited noteworthy advantages to get tunable emission, excellent photostability, and biocompatibility. Incorporating AIEgens into polymer design has yielded diversified polymer systems with fascinating photophysical characteristics. Again, stimuli-responsive polymers are capable of undergoing chemical and/or physical property changes on receiving signals from single or multiple stimuli. The combination of the AIE property and stimuli responses in a single polymer platform provides a feasible and effective strategy for the development of smart polymers with promising biomedical applications. Herein, the advancements in stimuli-responsive polymers with AIE characteristics for biomedical applications are summarized. AIE-active polymers are first categorized into conventional π–π conjugated and nonconventional fluorophore systems and then subdivided based on various stimuli, such as pH, redox, enzyme, reactive oxygen species (ROS), and temperature. In each section, the design strategies of the smart polymers and their biomedical applications, including bioimaging, cancer theranostics, gene delivery, and antimicrobial examples, are introduced. The current challenges and future perspectives of this field are also stated at the end of this review article.

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Construction of hyperbranched polysiloxane-based multifunctional fluorescent prodrug for preferential cellular uptake and dual-responsive drug release

Cited by 11 publications

References 53 publications

pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound

pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound

Eu³⁺ Coordinated Hyperbranched Polysiloxane with Multicolor Emission and Long Fluorescence Lifetime^†

Stimuli-Responsive Aggregation-Induced Emission (AIE)-Active Polymers for Biomedical Applications

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Construction of hyperbranched polysiloxane-based multifunctional fluorescent prodrug for preferential cellular uptake and dual-responsive drug release

Cited by 11 publications

References 53 publications

pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound

pH-Activatable Charge-Reversal Polymer-Based Nanocarriers for Targeted Delivery of Antihepatoma Compound

Eu3+ Coordinated Hyperbranched Polysiloxane with Multicolor Emission and Long Fluorescence Lifetime†

Stimuli-Responsive Aggregation-Induced Emission (AIE)-Active Polymers for Biomedical Applications

Contact Info

Product

Resources

About

Eu³⁺ Coordinated Hyperbranched Polysiloxane with Multicolor Emission and Long Fluorescence Lifetime^†