Consumo habitual de chocolate y estado cognitivo en los adultos mayores españoles

Arbelaez, Edilberto Orozco; Banegas, José R.; Artalejo, Fernando Rodrı́guez; García, Enrique Baca

doi:10.20960/nh.630

Cited by 1 publication

(2 citation statements)

References 22 publications

(25 reference statements)

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“…In line with the observed link between the cognitive construct score and moderate chocolate consumption, a positive association between cognitive performance and im-proved memory has previously been attributed to habitual chocolate intake in patients without atrial fibrillation [6][7][8][9]. Interestingly, it has also been recognised that the highest number of Nobel Prize winners can be found in countries with the highest chocolate consumption [32].…”

Section: Original Articlementioning

confidence: 56%

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Association of chocolate consumption with neurological and cardiovascular outcomes in atrial fibrillation: data from two Swiss atrial fibrillation cohort studies (Swiss-AF and BEAT-AF)

Stauber,

Müller,

Rommers

et al. 2023

Swiss Med Wkly

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AIM: To assess the associations of chocolate consumption with neurocognitive function, brain lesions on magnetic resonance imaging (MRI), and cardiovascular outcome in patients with atrial fibrillation (AF). METHODS: We analysed data from patients of two prospective multicentre Swiss atrial fibrillation cohort studies (Swiss-AF) and (BEAT-AF). Assessments of MRI findings and neurocognitive function were performed only in the Swiss-AF population (in 1727 of 2415 patients [71.5%] with a complete data set), as patients enrolled in BEAT-AF were not systematically evaluated for these outcomes. Otherwise, the two cohorts had an equivalent set of clinical assessments. Clinical outcome analysis was performed in 3931 patients of both cohorts. Chocolate consumption was assessed by questionnaire. Patients were categorised as no/low chocolate consumption (No/Low-Ch) ≤1 servings/week, moderate chocolate consumption (Mod-Ch) >1–6 servings/week, and high chocolate consumption (High-Ch) >6 servings/week, respectively. Brain lesions were evaluated by MRI. Assessment of cognitive function was performed by neurocognitive functional testing and included global cognition measurement with a cognitive construct score. Cerebral MRI and cognition were evaluated at baseline. Cross-sectional associations between chocolate consumption and MRI findings were analysed by multivariate logistic regression models and associations with neurocognitive function by multivariate linear regression models. Clinical outcome events during follow-up were recorded and assessed by a clinical event committee. The associations between chocolate consumption and clinical outcomes were evaluated by Cox regression models. The median follow-up time was 6 years. RESULTS: Chocolate consumption was not associated with prevalence or volume of vascular brain lesions on MRI, nor major adverse cardiac events (ischaemic stroke, myocardial infarction, cardiovascular death). However, No/Low-Ch was independently associated with a lower cognitive construct score compared to Mod-Ch (No/Low-Ch vs. Mod-Ch: coeff. –0.05, 95% CI –0.10–0), whereas other neurocognitive function tests were not independently associated with chocolate consumption categories. In addition, there was a higher risk of heart failure hospitalisation (No/Low-Ch vs. Mod-Ch: HR 1.24, 95% CI 1.01–1.52) and of all-cause mortality (No/Low-Ch vs. Mod-Ch: HR 1.29, 95% CI 1.06–1.58) in No/Low-Ch compared to Mod-Ch. No significant associations with the evaluated outcomes were observed when High-Ch was compared to Mod-Ch. CONCLUSION: While chocolate consumption was not associated with MRI findings and major adverse cardiac events in an atrial fibrillation population, No/Low-Ch was associated with a lower cognitive construct score, higher risk of heart failure hospitalisation and increased all-cause mortality compared to Mod-Ch. ClinicalTrials.gov Identifier: NCT02105844

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Section: Original Articlementioning

confidence: 56%

“…Atrial fibrillation has been associated with an increased risk of cardiovascular morbidity and death [2]. According to previous investigations, chocolate consumption is linked to a decreased risk of cardiovascular and cerebrovascular disease [3][4][5] and may affect cognitive function [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%