Consumption of a defined, plant‐based diet reduces lipoprotein(a), inflammation, and other atherogenic lipoproteins and particles within 4 weeks

Abstract

A defined, plant-based diet has a favorable impact on Lp(a), inflammatory indicators, and other atherogenic lipoproteins and particles. Lp(a) concentration was previously thought to be only minimally altered by dietary interventions. In this protocol however, a defined plant-based diet was shown to substantially reduce this biomarker. Further investigation is required to elucidate the specific mechanisms that contribute to the reductions in Lp(a) concentrations, which may include alterations in gene expression.

A Traditional Korean Diet with a Low Dietary Inflammatory Index Increases Anti-Inflammatory IL-10 and Decreases Pro-Inflammatory NF-κB in a Small Dietary Intervention Study

“…Fibrinogen synthesis is triggered by the ingestion of a meal [ 39 ]. Westernized diet increases [ 40 ] and plant-based diet reduces serum fibrinogen levels [ 41 ]. However, in the present study there was no significant change in the fibrinogen levels.…”

Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets

“…It is widely known that consuming a properly composed diet has been associated with better health status, due to the protective effect against various chronic diseases [ 37 , 45 ]. Evidence regarding the role of diet quality on glucose and lipid metabolism and inflammatory markers has been established in multiple observational studies [ 45 , 46 , 47 , 48 , 49 ]. The authors reported that a plant-based pattern and the Mediterranean diet (characterized by a high consumption of vegetables, fruits, legumes, olive oil, and low consumption of red meats) are associated with favorable health status and less inflammation [ 25 , 27 ].…”

Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule

“…Screening for increases in Lp(a) levels in the general population is still not recommended [11]. Because the majority of circulating Lp(a) molecules are genetically determined with little effect from diet and environment [196] and because plasma concentrations do not vary considerably around a preset baseline over a lifespan (<10%) in any individual, it is ere is an inverse relationship between weight plasma Lp(a) concentration and obesity [63] Diet Majority of the reports have shown no to minimum reduction [181]; however, a defined plant-based diet [182] and fish oils were found to reduce plasma Lp(a) by 10% [180] Journal of Lipids 14…”

“…In four phase III trials, 382 participants receiving maximally tolerated serum Lp(a) concentration is regulated independently of diet, other lipoprotein classes, and long-term or acute rigorous physical exercise [13,181], despite these activities producing a favorably improved lipid profile [13,199]. Conversely, a recent study has shown that a plant-based diet substantially decreased inflammatory biomarkers and atherogenic lipoproteins, including Lp(a) [182].…”