“…Besides, it should be highlighted that despite pruritus was the most frequent symptom in our series, it might not be the main subjective clinical feature in some children. Moreover, diagnosis of ACD from chlorhexidine might be delayed for months or years, as skin lesions are frequently attributed to cellulitis, 3 local reactions to vaccines 8 or ACD from plasters, 1 among others. Successive exposures to chlorhexidine due to delay in diagnosis might lead to further ACD episodes, and even to anaphylaxis, considering that immediate and delayed hypersensitivity may coexist.…”