1984
DOI: 10.1159/000233452
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Contact Sensitivity in Guinea Pigs: Allogeneic Reaction and Carrier Specificity in Antigenic Recognition

Abstract: In the present paper it is shown that both induction and elicitation of 2,4-dinitrochlorobenzene-contact sensitivity in guinea pigs are genetically controlled. This genetical control is operating by two somehow different mechanisms. The recognition of hapten on allogeneic macrophages during the inductive phase is suppressed by the allogeneic response against these macrophages whereas the elicitation upon transfer of syngeneically primed lymphocytes is limited by the identity of at least some components of the … Show more

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