Contact vitiligo following a strong patch test reaction to triglycidyl‐<i>p</i>‐aminophenol in an aircraft industry worker: case report and review of the literature

Jappe, Uta; Geier, Johannes; Hausen, B. M.

doi:10.1111/j.0105-1873.2005.00651.x

Cited by 23 publications

(12 citation statements)

References 8 publications

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“…For chemical provoking factors, seven categories were differentiated: bleaching agents (I), pesticides (II), rubber (III), petroleum (IV), glue (V), photochemicals (VI) and solvents (VII). These chemicals are suspect provoking factors for vitiligo 7–10,16–22 . If required, patients could indicate other factors (category VIII).…”

Section: Methodsmentioning

confidence: 99%

Provoking factors, including chemicals, in Dutch patients with vitiligo

et al. 2013

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Section: Methodsmentioning

confidence: 99%

Provoking factors, including chemicals, in Dutch patients with vitiligo

et al. 2013

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“…The mechanism involves specific dendritic/T-cell activation and melanocyte recognition. The latter can also be triggered by treatment with chemical sensitizers: 4-tertiary butyl phenol (Kroll et al, 2005) and triglycidyl-p-aminophenol (Jappe et al, 2005) seem to be candidates.…”

Section: Melanocyte Lossmentioning

confidence: 99%

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Solano¹,

Briganti²,

Picardo³

et al. 2006

Pigment Cell Research

620

524

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SummaryAn overview of agents causing hypopigmentation in human skin is presented. The review is organized to put forward groups of biological and chemical agents. Their mechanisms of action cover (i) tyrosinase inhibition, maturation and enhancement of its degradation; (ii) Mitf inhibition; (iii) downregulation of MC1R activity; (iv) interference with melanosome maturation and transfer; (v) melanocyte loss, desquamation and chemical peeling. Tyrosinase inhibition is the most common approach to achieve skin hypopigmentation as this enzyme catalyses the rate-limiting step of pigmentation. Despite the large number of tyrosinase inhibitors in vitro, only a few are able to induce effects in clinical trials. The gap between in-vitro and in-vivo studies suggests that innovative strategies are needed for validating their efficacy and safety. Successful treatments need the combination of two or more agents acting on different mechanisms to achieve a synergistic effect. In addition to tyrosinase inhibition, other parameters related to cytotoxicity, solubility, cutaneous absorption, penetration and stability of the agents should be considered. The screening test system is also very important as keratinocytes play an active role in modulating melanogenesis within melanocytes. Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase.

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“…Phenolic/catechol derivatives are major chemicals known to be associated with vitiligo, and could induce the condition8,11,12,13,14. A variety of allergens that cause allergic contact dermatitis (ACD) might also be initiating factors of contact/occupational vitiligo15,16,17,18,19,20. However, the frequency of vitiligo occurrence in patients of particular occupations, and the associated environmental and occupational exposures have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

A Multicenter Collaborative Study by the Korean Society of Vitiligo about Patients' Occupations and the Provoking Factors of Vitiligo

et al. 2014

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BackgroundIt was previously thought that persons with genetic predispositions to vitiligo develop the condition after exposure to various precipitating environmental factors. However, in many cases, the aggravating factors of vitiligo have not been clearly identified.ObjectiveTo identify the aggravating factors of vitiligo in the working environment and daily life.MethodsA total of 489 vitiligo patients were recruited from 10 institutions in South Korea; patients were provided with a questionnaire about environmental factors and behavior patterns in the workplace and in daily life, and their association with vitiligo.ResultsNinety-five of the 470 enrolled patients (20.2%) answered that environmental risk factors in daily life and in the workplace affected the development of vitiligo. The most frequently attributed causes were trauma and burn (13.6%), followed by sunlight (12.8%), stress (12.8%), cleaning products/disinfectant/chemicals (4.9%), and hair dye (2.1%).ConclusionVitiligo of the hand and foot was associated with frequent exposure to aggravating materials and overexposure to sunlight, along with frequent trauma of these areas, all of which could be considered important risk factors of vitiligo. The development of vitiligo could potentially be controlled through the early detection of aggravating factors.

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Contact vitiligo following a strong patch test reaction to triglycidyl‐p‐aminophenol in an aircraft industry worker: case report and review of the literature

Cited by 23 publications

References 8 publications

Provoking factors, including chemicals, in Dutch patients with vitiligo

Provoking factors, including chemicals, in Dutch patients with vitiligo

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

A Multicenter Collaborative Study by the Korean Society of Vitiligo about Patients' Occupations and the Provoking Factors of Vitiligo

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