As part of the Horizon 2020 InfraROB project aimed at enhancing road safety through innovative robotic solutions, a compact autonomous vehicle has been developed to repair asphalt potholes. Central to this system is a 3D printer capable of extruding a novel cold-asphalt mixture, specifically designed for patching road surfaces. The printer is mounted on a small robot that autonomously navigates to potholes, while the human operator controls the operation from a secure location outside the traffic area. The system’s development involved several key steps: designing the repair mixture, constructing the 3D printer for mixture extrusion, implementing a photogrammetric technique to accurately measure pothole geometry for printing, and integrating the extrusion system with the robotic platform. Two preliminary tests were conducted in controlled environments at Sapienza University of Rome to check the reliability of calculation of the amount of material needed to fill in the potholes. Finally, the entire procedure was tested on an Italian motorway, demonstrating the system’s functionality without encountering operational issues.