Contaje absoluto de linfocitos como factor pronóstico en la leucemia aguda linfoblástica del niño

Martinez, Angel; A, González Otero; Svarch, Eva; A, Arencibia Nuñez; Jc, Jaime; Dorticós, E; Sarduy, S; González, Leslie Pinedo

doi:10.1016/j.anpedi.2011.07.001

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…Thus, both monocytes and lymphocytes might play major roles in the inflammatory response of cancer. Previous studies have found that each of these two leukocyte subsets or combination of LMR has been demonstrated independently associated with the prognosis of various cancers [34,15,16,19,20,17,21]. Similarly, our study demonstrated that pretreatment LMR level was an independent prognostic factor for both PFS and OS in sporadic BL.…”

Section: Discussionsupporting

confidence: 72%

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Peripheral blood lymphocyte to monocyte ratio identifies high-risk adult patients with sporadic Burkitt lymphoma

Wang

Xia

et al. 2015

Ann Hematol

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Adult sporadic Burkitt lymphoma (BL) is a rare subtype of lymphoma. In this retrospective study, we investigated the prognostic value of pretreatment lymphocyte to monocyte ratio (LMR) in a cohort of 62 patients. Using LMR <2.6 as the optimal cutoff point, 24 patients (38.7 %) had LMR <2.6. The complete response rates in high-LMR group and low-LMR group were 90.9 and 65.0 %, respectively (P = 0.019). At a median follow-up time of 41 months, the 3-year progression-free survival (PFS) rate and overall survival (OS) rates were 76 and 80 %, respectively. In a multivariate Cox regression model, it was found that the presence of bone marrow infiltration and low LMR were independently adverse prognostic factors for both PFS and OS. In the whole group, the addition of rituximab to treatment did not benefit patients significantly in PFS and OS. In subgroup analysis, in patients with high LMR, addition of rituximab can significantly improve survival outcomes (P = 0.046). In conclusion, we firstly found that low LMR (<2.60) was an independently adverse prognostic factor in adult patients with sporadic BL. Intensive chemotherapy could cure the majority of patients in our study, and the pretreatment LMR might predict the value of rituximab in this age population.

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Section: Discussionsupporting

confidence: 72%

“…It is now widely recognized that cancer-associated inflammation may play a role in tumor progression [15][16][17][18][19][20]. Inflammation may also affect the quality of the host immune response.…”

Section: Introductionmentioning

confidence: 99%

Peripheral blood lymphocyte to monocyte ratio identifies high-risk adult patients with sporadic Burkitt lymphoma

Wang

Xia

et al. 2015

Ann Hematol

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“…Our study demonstrated that pretreatment MLR level was an independent prognostic factor for both PFS and OS in pulmonary LELC. Although the mechanisms for this correlation between MLR and survival have not been investigated, previous studies have found that each of these two leukocyte subsets or combination of MLR has been found to be independently associated with the prognosis of various cancers [ 6 – 10 , 14 , 20 ]. High number of monocytes in circulating blood may promote the potential creation of TAMs in tumor microenvironment [ 21 ], therefore contribute to the tumor progression or metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…It is now widely recognized that cancer-associated inflammation is very common in tumor progression and associated with survival in variety of cancers [ 5 ]. Lymphocytes and monocytes are the main type of immune cells involved in the inflammatory process and have been demonstrated to be associated with the prognosis of many malignancies [ 6 – 9 ]. Recently, the pretreatment lymphocyte-to-monocyte ratio (LMR) or monocyte-to-lymphocyte ratio (MLR) has been shown to be a prognostic factor for clinical outcomes in diffuse large B-cell lymphoma[ 8 ] and lung cancers[ 10 ].…”

Section: Introductionmentioning

confidence: 99%

An Elevated Peripheral Blood Monocyte-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Primary Pulmonary Lymphoepithelioma-Like Carcinoma

Wang

Wen

et al. 2015

PLoS ONE

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Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer. In this study, we retrospectively reviewed the data from 74 consecutive patients with pulmonary LELC and investigated the prognostic value of pretreatment monocyte-to-lymphocyte ratio (MLR). The cut-off value determined by ROC curve for MLR was 0.262. According to this cut-off value, 36 (48.6%) patients had lower MLR value (<0.262) at diagnosis. There was no significant correlation between MLR level and gender, age, smoking history, stage, and lactate dehydrogenase (LDH) level. The 2-year, 5-year, and 10-year OS rate were 86%, 72%, and 61%, respectively; the 2-year, 5-year, and 10-year PFS rate were 71%, 63%, and 49%, respectively. In univariate analysis, advanced stage, elevated LDH level, and higher MLR value (> = 0.262) were significantly associated with poor OS and PFS. In a multivariate Cox regression model that included stage, LDH and MLR level, all of these three factors were found to be independent prognostic factors for both PFS and OS. In patients who received radical surgery, MLR level remained significantly correlated with OS and PFS. In conclusion, we firstly demonstrated that pretreatment MLR can be used as a useful independent prognostic marker in patients with pulmonary LELC, and might guide us to optimize the treatment strategies. However, due to the relatively rarity of this disease and the limitation of a retrospective study, further prospective studies performed in multicenter are necessary to validate the prognostic value of MLR in pulmonary LELC.

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Peripheral blood lymphocyte recovery and overall survival in pediatric acute lymphoblastic leukemia

Hatzipantelis

Pana

Vlachou

et al. 2013

Pediatric Blood & Cancer

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Contaje absoluto de linfocitos como factor pronóstico en la leucemia aguda linfoblástica del niño

Cited by 8 publications

References 21 publications

Peripheral blood lymphocyte to monocyte ratio identifies high-risk adult patients with sporadic Burkitt lymphoma

Peripheral blood lymphocyte to monocyte ratio identifies high-risk adult patients with sporadic Burkitt lymphoma

An Elevated Peripheral Blood Monocyte-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Primary Pulmonary Lymphoepithelioma-Like Carcinoma

Peripheral blood lymphocyte recovery and overall survival in pediatric acute lymphoblastic leukemia

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