Contamination levels of human pharmaceutical compounds in French surface and drinking water

Mompelat, Sophie; Thomas, Olivier; Bot, Barbara Le

doi:10.1039/c1em10335k

Cited by 53 publications

(28 citation statements)

References 58 publications

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“…The concentrations varied across a range from sub ng/L concentrations to tens of ng/L, which were generally comparable to the reported levels from other published references concerned with DWSs of The Netherlands (de Jongh et al, 2012), United States (Loraine and Pettigrove, 2005;Stackelberg et al, 2007;Focazio et al, 2008;Benotti et al, 2009;Wang et al, 2011;Padhye et al, 2014), Canada (Kleywegt et al, 2011), France (Vulliet et al, 2011;Mompelat et al, 2011), Spain (Boleda et al, 2011;Huerta-Fontela et al, 2011) and South Korea (Kim et al, 2007). The concentration levels in this survey were similar to reports on those in the DWSs of the Chongqing area of China (Chang et al, 2010;Yan et al, 2014).…”

Section: Concentration Levelssupporting

confidence: 76%

“…The detected pharmaceuticals included antibiotics, an antiepileptic, serotonin re-uptake inhibitors, an antiulcer agent, a β-blocker, an antihistamine, an antiasthma drug, tranquilizers, a lipid-regulating agent, a calcium channel blocker and hormones. The types of pharmaceuticals found in DWSs in China are similar to those found in other countries, such as the U.S. (Benotti et al, 2009;Focazio et al, 2008;Wang et al, 2011), Canada (Kleywegt et al, 2011), Denmark (de Jongh et al, 2012, Spain (Valcárcel et al, 2013), France (Mompelat et al, 2011;Vulliet et al, 2011) and South Korea (Kim et al, 2007).…”

Section: Detections Of Pharmaceuticals In Dwsssupporting

confidence: 55%

“…i South Korea (Kim et al, 2007). j France (Mompelat et al, 2011). k Spain (Huerta-Fontela et al, 2011).…”

Section: Frequency Of Detectionmentioning

confidence: 99%

“…Multiple-classes of pharmaceuticals have been detected in DWSs in countries such as the United States (U.S.) (Benotti et al, 2009;Focazio et al, 2008), Canada (Kleywegt et al, 2011) and several European countries (de Jongh et al, 2012;Kuch Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/ecoenv and Ballschmiter, 2001; Mompelat et al, 2011;Valcárcel et al, 2013;Vulliet et al, 2011). In a national survey performed by the U.S. Geological Survey, several classes of pharmaceuticals, including antibiotics, prescription drugs, non-prescription drugs and other wastewater-related drugs, were detectable (Focazio et al, 2008), and the maximum concentrations of the detected pharmaceuticals ranged from 0.019 μg/L to 0.30 μg/L.…”

Section: Introductionmentioning

confidence: 99%

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Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China

Sun

Luo

Wang

et al. 2015

Ecotoxicology and Environmental Safety

132

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a b s t r a c tPharmaceuticals in drinking water sources (DWSs) have raised significant concerns for their persistent input and potential human health risks. Currently, little is known about the occurrence of pharmaceuticals in DWSs in China. In this study, a survey for multi-class pharmaceuticals in DWSs of five major river watersheds in China was conducted from 2012 to 2013. Samples were collected from 25 sampling sites in rivers and reservoirs. 135 pharmaceuticals were analyzed using solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. The results showed that a total of 70 pharmaceuticals were present in the samples, and the most frequently detected ones included sulfonamides, macrolides, antiepileptic drugs, anti-inflammatory drugs, and β-blockers, etc. Amongst these, maximum concentrations of lincomycin, sulfamethoxazole, acetaminophen and paraxanthine were between 44 ng/L and 134 ng/L, and those of metoprolol, diphenhydramine, venlafaxine, nalidixic acid and androstenedione were less than 1 ng/L. Concentrations of the two that were most persistent, DEET and carbamazepine, were 0.8-10.2 ng/L and 0.01-3.5 ng/L, respectively. Higher concentrations of cotinine were observed in warm season than in cold season, while concentrations of lincomycin were the opposite. In a causality analysis, the occurrence of pharmaceuticals in DWSs depends mainly on the detection limits of the methods, their usage and the persistence in the aquatic environment.

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Section: Concentration Levelssupporting

confidence: 76%

Section: Detections Of Pharmaceuticals In Dwsssupporting

confidence: 55%

“…i South Korea (Kim et al, 2007). j France (Mompelat et al, 2011). k Spain (Huerta-Fontela et al, 2011).…”

Section: Frequency Of Detectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China

Sun

Luo

Wang

et al. 2015

Ecotoxicology and Environmental Safety

132

View full text Add to dashboard Cite

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“…A major challenge in water reuse, particularly for indirect or direct potable purposes, is the reliable removal of health-concerning trace organic contaminants such as pharmaceutically active compounds (PhACs). These low molecular contaminants are widely detected in secondary treated effluent and sewage impacted water bodies [2][3][4][5]. The occurrence of PhACs in the aquatic environment is of significant concern given their high pharmaceutically active properties, which can cause possible adverse effects upon human health and the ecosystem [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Impact of chemical cleaning on the nanofiltration of pharmaceutically active compounds (PhACs): The role of cleaning temperature

Simon

Price

Nghiem

2013

Journal of the Taiwan Institute of Chemical Engineers

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This study investigated the impact of chemical cleaning on the physicochemical properties of a nanofiltration membrane and its subsequent separation efficiency of inorganic salts and two pharmaceutically active compounds (PhACs), sulfamethoxazole and carbamazepine. Chemical cleaning was simulated by immersing virgin membrane samples in aqueous citric acid, sodium hydroxide (NaOH), ethylenediaminetetraacetic-acid (EDTA) and sodium dodecyl sulphate (SDS) at various temperatures for 18 h. The cleaning temperature did not exert any discernible impact on the surface charge of the NF270 membrane selected in this study. However, high cleaning temperatures were shown to either amplify or reduce the impact of chemical cleaning on several other membrane properties (including hydrophobicity, surface roughness and permeability) as well as the rejection of both inorganic salts and PhACs. The influence of chemical cleaning on the membrane surface roughness was enhanced at elevated cleaning temperatures. Similarly, at a high cleaning temperature, caustic and acidic cleaning caused a more significant increase in the membrane surface hydrophobicity than that at an ambient temperature. An increase in the cleaning temperature could also slightly amplify the decrease in the membrane permeability due to acidic cleaning. When a caustic cleaning solution (pH 11.5) was used, the membrane permeability only varied slightly with the temperature. Results obtained from Fourier transform infrared spectroscopy (FTIR) analysis suggest that chemical cleaning even at a high temperature did not permanently alter the chemical composition of the membrane active or support layer. Indeed, the effects of chemical cleaning at a high temperature on the physicochemical properties of the membrane could be attributed to the conformational changes of the membrane polymeric matrix. Chemical cleaning using citric acid, SDS or EDTA at a high temperature resulted in a considerable increase in the rejection of salts and PhACs in their neutral form. On the other hand, caustic cleaning at an elevated temperature had no discernible impact on the rejection of inorganic salts and neutral PhACs. This is because caustic cleaning and an elevated cleaning temperature cause opposing effects on the rejection of these solutes. Chemical cleaning at all temperatures investigated in this study did not affect the removal of negatively charged sulfamethoxazole.

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Therapeutic Classes ofPCsin the Environment

2017

Emerging Pollutants

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Contamination levels of human pharmaceutical compounds in French surface and drinking water

Cited by 53 publications

References 58 publications

Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China

Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China

Impact of chemical cleaning on the nanofiltration of pharmaceutically active compounds (PhACs): The role of cleaning temperature

Therapeutic Classes ofPCsin the Environment

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