Contemporary Concise Review 2018: Lung cancer and pleural disease

Conway, Francesca; Garner, Justin; Orton, Christopher M.; Srikanthan, Karthi; Kemp, Samuel V.; Shah, Pallav L.

doi:10.1111/resp.13499

Cited by 5 publications

(4 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Spontan pnömotoraks (SPn) ise yine etyolojisine göre primer ve edinsel olarak ikiye ayrılır (1). Etyolojik olarak herhangi bir nedenin ortaya konulamadığı durumlar primer spontan pnömotoraks (PSPn) olarak adlandırılırken, altta yatan nedenin tanımlandığı durumlar ise sekonder SPn olarak ifade edilmektedir (3)(4). Akciğer kanseri, intertisiyel pnömoni, pulmoner amfizem, infeksiyoz nedenler, pulmoner bülloma, pulmoner fibrozis, pulmoner tüberkuloz, non-tüberküloz mikobakteriyel infeksiyon, Marfan sendromu, Birt-Hogg-Dub sendromu edinsel SPn'in en sık rastlanan nedenleri olarak karşımıza çıkmaktadır (1,(4)(5)(6).…”

Section: Introductionunclassified

Sternum Varyasyonlari İle Pri̇mer Spontan Pnömotoraks Arasindaki̇ İli̇şki̇ni̇n Bt Bulgulari İle Gösteri̇lmesi̇

Urfalı¹,

Tok²,

Özkul³

2023

atljm

View full text Add to dashboard Cite

Amaç: Yapısal akciğer bozukluğu, enfeksiyon veya travma gibi belirli etyolojik neden bulunmayan olgular “primer spontan pnömotoraks (PSPn)” olarak isimlendirilmektedir. Çalışmamızın birincil hedefi PSPn tanısı alan hastalarda pektus ekskavatum (PE) ve sternal varyasyonlar ile spontan pnömotoraks arasındaki ilişkiyi değerlendirmektir. Materyal-Metod: Retrospektif ve tek merkezli çalışmamıza Ocak 2016-Şubat 2019 tarihleri arasında Üniversitemiz acil servisine başvuran 30 PSPn olgusu, 30 kontrol grubu olarak toplam 60 olgu dahil edildi. Tüm görüntüler sternal varyasyonlar açısından 8 yıl toraks radyolojisi deneyimi olan, hastaların bilgilerini bilmeyen bir radyolog tarafından değerlendirildi. Haller indeksi, tüm olgular için mediasten penceresinde aksiyel toraks kesitleri üzerinde literatürde tanımlanan şekilde ölçüldü. Pectus excavatum tanısı konulan hastalar için Haller indeksinin 2’nin üzerinde olması kabul edildi. Tüm istatiksel analiz SPSS (version 20.0, SPSS Inc., IL, US) programı ile gerçekleştirildi. Bulgular: Haller indeksine göre hastalar <2 ve >2 olan iki gruba ayrıldığında her iki grup arasında SPn açısından istatistiksel farklılık izlendi (p=0,009). Sternal varyasyon varlığı PSPn grubunun %50’sinde, kontrol grubunun ise %23’ünde ortaya konuldu. Uzun ksifoid poçes, PSPn grubunda en sık rastlanan sternal varyasyon olarak bulundu (%20). Sonuç: Uzun ksifoid proçes ve pektus ekskavatum deformitesi gibi sternal varyasyonlar, spontan pnömotoraks gelişiminde rol oynamaktadır. Uzun ksifoid proçesin tekrarlayan spontan pnömotoraks nedeni olup olmadığının araştırılması ve operasyon açısından değerlendirme yapılabileceği düşünülmüştür.

show abstract

Section: Introductionunclassified

Sternum Varyasyonlari İle Pri̇mer Spontan Pnömotoraks Arasindaki̇ İli̇şki̇ni̇n Bt Bulgulari İle Gösteri̇lmesi̇

Urfalı¹,

Tok²,

Özkul³

2023

atljm

View full text Add to dashboard Cite

show abstract

“…As branching proceeds, proximal-distal patterning is established, and cellular specification follows [7][8][9] . Thus, bud tip progenitors persist and proliferate, then undergo differentiation into type I and type II pneumocytes 8 , and the cells of the primal airway stalk differentiate into multiple proximal cell types [10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

“…Lung bud tip progenitors persist and proliferate and subsequently undergo differentiation into alveolar type 1 (AT1) and alveolar type 2 (AT2) cells 3 . The cells of the primal airway stalk differentiate into multiple proximal cell types 12, 13, 14, 15 .…”

Section: Introductionmentioning

confidence: 99%

Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

Foxworth

Wells

Ocana-Lopez

et al. 2021

Preprint

View full text Add to dashboard Cite

Proper lung development and function requires two independent but interrelated processes: branching morphogenesis to form the airway tree, and alveolar cell differentiation for peripheral gas exchange. The disruption of either branching or differentiation results in severe respiratory deficiencies and often in neonatal death. The molecular mechanisms that control branching patterns and the transition to alveolar differentiation are not completely understood. Here we report on the in vitro and in vivo characterization of the lungs of mouse embryos lacking a functional Svep1 gene. Our data demonstrate that the SVEP1 extracellular matrix protein is critical for the process of transitioning from branching to alveolar maturation. Svep1-/- embryos on a C57BL/6J genetic background are characterized by hypoplastic lungs and a disorganized increase in distal airway tips which disrupts airway architecture and lobe shape. The lungs of Svep1 knockout embryos also have defects in alveolar differentiation. In vitro lung explant experiments demonstrated that SVEP1 normally inhibits branching morphogenesis and that treatment with a SVEP1 peptide can rescue the branching defects observed in Svep1 knockouts. Our findings reveal for the first time that Svep1 is essential for constructing the basic airway architecture and for the transition from lung branching to alveolar differentiation. Our results suggest therapeutic strategies to enhance lung development in patients with life-threatening respiratory disorders such as the lung hypoplasia and prematurity observed in neonates with congenital diaphragmatic hernia (CDH).

show abstract

“…NSCLC includes adenocarcinoma, squamous cell lung carcinoma, undifferentiated large cell carcinoma, adenosquamous carcinoma and bronchioalveolar carcinoma; the first three are the best known types [6]. The survival of patients with NSCLC is still bleak due to delayed diagnosis, undisciplined treatment, incident chemoresistance, and frequent tumor recurrence [7][8][9]. Thus, thorough investigation of the molecular mechanisms underlying lung carcinogenesis remains an urgent task, for establishing new and effective guidelines for cancer screening and for identifying novel genetic targets for treatments.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of hsa-microRNA-204-5p and identification of its potential regulatory network in non-small cell lung cancer: RT-qPCR, bioinformatic- and meta-analyses

Liang

Gan

et al. 2020

Respir Res

View full text Add to dashboard Cite

Background: Pulmonary malignant neoplasms have a high worldwide morbidity and mortality, so the study of these malignancies using microRNAs (miRNAs) has attracted great interest and enthusiasm. The aim of this study was to determine the clinical effect of hsa-microRNA-204-5p (miR-204-5p) and its underlying molecular mechanisms in non-small cell lung cancer (NSCLC). Methods: Expression of miR-204-5p was investigated by real-time quantitative PCR (RT-qPCR). After data mining from public online repositories, several integrative assessment methods, including receiver operating characteristic (ROC) curves, hazard ratios (HR) with 95% confidence intervals (95% CI), and comprehensive meta-analyses, were conducted to explore the expression and clinical utility of miR-204-5p. The potential objects regulated and controlled by miR-204-5p in the course of NSCLC were identified by estimated target prediction and analysis. The regulatory network of miR-204-5p, with its target genes and transcription factors (TFs), was structured from database evidence and literature references. Results: The expression of miR-204-5p was downregulated in NSCLC, and the downtrend was related to gender, histological type, vascular invasion, tumor size, clinicopathologic grade and lymph node metastasis (P<0.05). MiR-204-5p was useful in prognosis, but was deemed unsuitable at present as an auxiliary diagnostic or prognostic risk factor for NSCLC due to the lack of statistical significance in meta-analyses and absence of large-scale investigations. Gene enrichment and annotation analyses identified miR-204-5p candidate targets that took part in various genetic activities and biological functions. The predicted TFs, like MAX, MYC, and RUNX1, interfered in regulatory networks involving miR-204-5p and its predicted hub genes, though a modulatory loop or axis of the miRNA-TF-gene that was out of range with shortage in database prediction, experimental proof and literature confirmation. Conclusions: The frequently observed decrease in miR-204-5p was helpful for NSCLC diagnosis. The estimated target genes and TFs contributed to the anti-oncogene effects of miR-204-5p.

show abstract

Contemporary Concise Review 2018: Lung cancer and pleural disease

Cited by 5 publications

References 57 publications

Sternum Varyasyonlari İle Pri̇mer Spontan Pnömotoraks Arasindaki̇ İli̇şki̇ni̇n Bt Bulgulari İle Gösteri̇lmesi̇

Sternum Varyasyonlari İle Pri̇mer Spontan Pnömotoraks Arasindaki̇ İli̇şki̇ni̇n Bt Bulgulari İle Gösteri̇lmesi̇

Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

Downregulation of hsa-microRNA-204-5p and identification of its potential regulatory network in non-small cell lung cancer: RT-qPCR, bioinformatic- and meta-analyses

Contact Info

Product

Resources

About