Contemporary considerations in solid organ transplantation utilizing DCD donors

Siddiqui, Farjad; Al-Adwan, Yazan; Subramanian, Jayanthan; Henry, Mitchell L.

doi:10.1016/j.tpr.2022.100118

Cited by 3 publications

(5 citation statements)

References 89 publications

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“…Experience of the procurement and transplanting surgeons are pivotal. The success of a DCD program depends on the dedication of the donor hospitals, organ procurement organizations, and transplant centers 35 . The improving survival of DCD grafts compared to DBD grafts is due to better selection of potential donors, standardization of recovery techniques and improved preservation of grafts.…”

Section: Applying Collaborative Leadership Methods To Increase the Or...mentioning

confidence: 99%

Collaborative leadership in transplantation: Blending clinical, business, and regulatory roles

Crespo,

Samra,

Korsun

et al. 2023

Clinical Transplantation

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Transplantation is a high‐risk, high‐cost treatment for end‐stage diseases and is the most strictly regulated area of healthcare in the United States. Thus, achieving success for patients and the program requires skillful and collaborative leadership. Various factors, such as outcomes, volume, and financial health, may measure the success of a transplant program. Strong collaboration between clinical and administrative leaders is key to achieving and maintaining success in those three categories. Clinical leaders of adult programs, such as medical and surgical directors, bear the primary responsibility for a program's volume, outcomes, and patient safety, while administrative directors are focused on business intelligence and regulatory compliance. This paper aims to provide readers with insights into the critical role of collaborative leadership in running a successful program, with a focus on clinical, business, and regulatory perspectives.

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Section: Applying Collaborative Leadership Methods To Increase the Or...mentioning

confidence: 99%

Collaborative leadership in transplantation: Blending clinical, business, and regulatory roles

Crespo,

Samra,

Korsun

et al. 2023

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…Minimizing CIT and using machine perfusion may be keys to successful utilization of ECD/DCD kidneys [60], particularly to reduce risk of delayed graft function [51].…”

Section: Donation After Circulatory Death Kidneysmentioning

confidence: 99%

“…Any synopsis of key avenues for increasing deceased donor organ utilization would be incomplete without addressing donation after circulatory death (DCD) [51], which has grown dramatically over the past two decades and now comprises nearly one-third of the donor pool. Between 2000 and 2022, the proportion of transplants from DCD donors rose as follows: kidney (2.0%→32.5%), liver (0.9%→11.6%), heart (0.0%→8.4%), lung (0.0%→7.5%) (Fig.…”

Section: Donation After Circulatory Deathmentioning

confidence: 99%

“…Transplanting kidneys from DCD donors over the age of 60 confers a large survival advantage (adjusted hazard rate: 0.52, P < 0.01) compared with declining an older DCD offer and waiting for a more ideal kidney [59]. Minimizing CIT and using machine perfusion may be keys to successful utilization of ECD/DCD kidneys [60], particularly to reduce risk of delayed graft function [51].…”

Section: Donation After Circulatory Deathmentioning

confidence: 99%

“…Although both unadjusted and adjusted survival rates remain slightly lower for DCD vs. DBD liver transplants, a strategy of keeping CITs low has been cited as a contributor to improvements over time in DCD outcomes [62]. Donor-recipient risk scores have been developed to aid in judicious recipient selection for DCD liver transplant, while thoraco-abdominal normothermic regional perfusion (TA-NRP) has potential to dramatically reduce risks of biliary complications and graft loss [51].…”

Section: Donation After Circulatory Deathmentioning

confidence: 99%

See 2 more Smart Citations

Beyond donation to organ utilization in the USA

Stewart

Lonze

2023

Current Opinion in Organ Transplantation

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Purpose of reviewThe deceased donor organ pool has broadened beyond young, otherwise healthy head trauma victims. But an abundance of donated organs only benefits patients if they are accepted, expeditiously transported and actually transplanted. This review focuses on postdonation challenges and opportunities to increase the number of transplants through improved organ utilization. Recent findingsWe build upon recently proposed changes in terminology for measuring organ utilization. Among organs recovered for transplant, the nonuse rate (NUR REC ) has risen above 25% for kidneys and pancreata. Among donors, the nonuse rate (NUR DON ) has risen to 40% for livers and exceeds 70% for thoracic organs. Programme-level variation in offer acceptance rates vastly exceeds variation in the traditional, 1-year survival benchmark. Key opportunities to boost utilization include donation after circulatory death and hepatitis C virus (HCV)þ organs; acute kidney injury and suboptimal biopsy kidneys; older and steatotic livers.

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Donation after circulatory death: An international view

KAHAN¹

2023

Transplantation Reports

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Contemporary considerations in solid organ transplantation utilizing DCD donors

Cited by 3 publications

References 89 publications

Collaborative leadership in transplantation: Blending clinical, business, and regulatory roles

Collaborative leadership in transplantation: Blending clinical, business, and regulatory roles

Beyond donation to organ utilization in the USA

Donation after circulatory death: An international view

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