Contemporary radiation therapy techniques in malignant pleural mesothelioma: a case report

Abstract

Malignant pleural mesothelioma (MPM) is a rare but very aggressive neoplasm. Prognosis is poor and the disease is fatal within 4-8 months without treatment. Even with a trimodality treatment approach, which has been shown to produce significant morbidity, median survival does not exceed 11 months. There is a need therefore for exploring new treatment options that can improve both qualitative and quantitative outcomes.This case report describes locally advanced malignant pleural mesothelioma treated with a unique, customized irradiation technique involving a combination of 3D conformal therapy and intensity modulated radiotherapy (IMRT). This allowed for treatment of the pleura to a high dose, while sparing the lung parenchyma. In this patient, our approach resulted in a prolonged remission. It is our hope that this stimulates new interest in the use of modern day radiation techniques in the treatment of MPM.