Contingent Negative Variation Is Associated with Cognitive Dysfunction and Secondary Progressive Disease Course in Multiple Sclerosis

Abstract

Background and PurposeThe relationship between contingent negative variation (CNV), which is an event-related potential, and cognition in multiple sclerosis (MS) has not been examined previously. The primary objective of the present study was thus to determine the association between CNV and cognition in a sample of MS patients.MethodsThe subjects of this study comprised 66 MS patients [50 with relapsing-remitting MS (RRMS) and 16 with secondary progressive MS (SPMS)] and 40 matched healthy volunteers. A neuropsychological battery was administered to all of the subjects; CNV recordings were made from the Cz, Fz, and Pz electrodes, and the amplitude and area under the curve (AUC) were measured at each electrode.ResultsRRMS patients exhibited CNVs with lower amplitudes and smaller AUCs than the controls at Pz. SPMS patients exhibited CNVs with lower amplitudes and smaller AUCs than the controls, and CNVs with a smaller amplitude than the RRMS patients at both Cz and Pz. After correcting for multiple comparisons, a lower CNV amplitude at Pz was significantly associated with worse performance on measures of speed of information processing, verbal fluency, verbal learning, and verbal recall.ConclusionsCNV may serve as a marker for disease progression and cognitive dysfunction in MS. Further studies with larger samples and wider electrode coverage are required to fully assess the value of CNV in these areas.

Cognitive assessment of idiopathic intracranial hypertension patients

“…Later on, Uysal and colleagues [42] found that CNV has been well related to the activity of the prefrontal cortex and correlated with the psychological preparation activities of the person as attention, anticipation, arousal, motivation, memory, preparation, and decision making.…”

Neurophysiologic tests screening cognitive impairment in idiopathic intracranial hypertension patients

“…In addition, CNV is an ERP that has been related to the activity of the prefrontal cortex and tells about the psychological preparation activities of the subject. It is well correlated with psychological activities such as anticipation, attention, arousal, memory, motivation, preparation, and decision (Uysal et al 2014 ). Thus, the findings of our NP study are somewhat aligned with the clinical study, highlighting the association of rather global cognitive dysfunction with IIH (Yri et al 2014 ).…”

“…Moreover, a cutoff for elevated CSF opening pressure needs to be specified (Friedman and Jacobson 2002 ). The event-related potential (ERP), P300, is involved in cognitive processing (Thakur et al 2011 ), whereas the contingent negative variation (CNV) is another ERP that is speculated to show awareness, attention, decision-making, planning, and conation, as well as readiness for a motor response (Uysal et al 2014 ).…”

Assessment of the Rescorla-Wagner Model With Experimental Data

“…Cognitive impairment is not rare in patients with epilepsy, due to different factors (the underlined pathology, side-effects from the pharmacotherapy, excessive cortical neuronal activity during ictal and interictal periods). There are reports that CNV may serve as a marker for disease progression and cognitive dysfunction in patients with multiple sclerosis (15). There are results showing differences in CNV amplitude between migraine patients and controls and these findings were used to follow the beta blockers treatment effects in migraine (16).…”