ObjectiveContinuous renal replacement therapy (CRRT) is well suited for treating
metabolic abnormalities and renal insufficiency associated with tumour lysis
syndrome (TLS). However, there is controversy regarding the choice of time
for CRRT, the selection of CRRT models, and methods of decreasing
complications of CRRT. This study aimed to evaluate the efficacy and
outcomes of daytime continuous veno-venous haemofiltration (CVVH) for
treating paediatric TLS.MethodsThe clinical features, technique-related complications, and prognosis were
prospectively analysed in eight paediatric patients with TLS who were
supported by daytime CVVH in West China Second University Hospital, Sichuan
University from January 2007 to July 2016.ResultsSeven patients were boys and one was a girl. All of the patients had
hyperphosphataemia, and there were four cases of hyperkalaemia, four cases
of hyperuricaemia, and two cases of hypocalcaemia. All of the patients
received one to 10 CVVH treatments. Urine output, renal function, serum uric
acid levels, and potassium, phosphate, and calcium levels returned to normal
in all of the patients, but recovery of renal function was relatively slow.
No significant adverse reactions were observed. All of the patients
recovered and were discharged.ConclusionDaytime CVVH is a safe and effective treatment for paediatric TLS.