Continued root development of immature permanent teeth after regenerative endodontics with or without a collagen membrane: A randomized, controlled clinical trial

Abstract

Background Recent studies evaluated the efficacy of a collagen membrane (Bio‐Gide) to promote root development in regenerative endodontics (REPs). However, the influence of etiology and tooth type on the results was not assessed. Aims To evaluate the quantitative and qualitative effect of a collagen membrane (Bio‐Gide), with and without the effect of etiology and tooth type, in promoting root development in immature teeth after REPs. Design Eighty nonvital immature teeth were divided randomly into two groups (40 teeth in each group). REPs were performed with (experimental group) and without (control group) a collagen membrane. All teeth were subjected to regular clinical and radiographical follow‐up. Results Seventy‐six teeth were included in the final analyses. The average follow‐up periods were 33.1 ± 21.8 months for the control group and 28.1± 18.6 months for the experimental group. Quantitative analysis of root development in the experimental group showed a greater increase in dentin wall thickness in the middle one‐third of the root compared to the control group, with or without the effect of etiology and tooth type. Six types of root development were observed. There was no significant difference in the type of tooth development between the two groups. Conclusion The use of a collagen membrane could promote an increase in dentin wall thickness in the middle one‐third of the root, and it had no significant effect in terms of the type of subsequent root development.

Effect of Platelet-Rich Plasma and Platelet-Rich Fibrin on apical response type in Regenerative Endodontics: A retrospective study

“…Selvakumar et al 24 reported a type 5 response in only one case and a type 3 response in all the remaining cases. In the study of Jiang et al 25 , type 1 and 3 root response types are the most common after RET. Shetty et al 26 observed all apical response types except type 2 after RET in three-dimensional radiographic examinations.…”

Rejeneratif Endodontik Tedavi Sonrası Nadir Görülen Ayrık Kök Gelişimi: Olgu Sunumu

“…8 tarafından oluşturulan apikal yanıt tiplerinden farklı olarak ana kökten ayrık olarak gelişen segmental kök gelişimi rapor edilmiştir. 9,10,14 Literatüre incelendiğinde ayrık kök gelişimi avülsiyon gibi travmalardan sonra, [15][16][17][18][19] apeksifikasyon tedavisi sonrası 12 ve RET sonrası 9,10,14 görülebilir. Bu durumun sorumlusu olarak genellikle travma gibi dişe gelen aşırı kuvvetler düşünülmüştür.…”

Biomaterial scaffolds for clinical procedures in endodontic regeneration

“…The current focus has been concentrated on direct clinical manipulation of cell-free regenerative endodontic therapy and the evaluation of a variety of biomaterial scaffolds. Over the last decade, a plethora of randomized controlled trials on REPs have been performed on evaluation or comparison of the different biomaterial scaffolds, including blood clot, collagen, PRP, PRF, PPP, PP, hydrogels, chitosan, and PLGA [ 28 , 31 , 40 , 88 , 89 , 93 , 128 , 186 , [232] , [233] , [234] , [235] , [236] , [237] , [238] , [239] , [240] , [241] ] ( Table 2 ). However, there is no sufficient evidence of a high level that compares the clinical outcome regarding the application of these biomaterial scaffolds in REPs. A systematic review and meta-analysis study was conducted to quantitatively assess the effect of various biomaterial scaffolds on the clinical outcomes of regenerative endodontic procedures in necrotic immature permanent teeth [ 242 ].…”