Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers

Chalyk, Natalia E.; Klochkov, Victor A.; Bandaletova, Tatiana; Kyle, Nigel H.; Petyaev, Ivan M.

doi:10.1016/j.nutres.2017.10.006

Cited by 57 publications

(45 citation statements)

References 59 publications

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“…In a mouse model of Alzheimer’s disease, astaxanthin in the form of an ester with docosahexaenoic acid, reduces oxidative stress and inflammasome activation [ 33 ]. Astaxanthin decreases the oxidative stress level, as indicated by lowered plasma malondialdehyde levels, and reverses age-related changes in residual skin surface components of middle-aged subjects [ 34 ]. When it is administered as a supplement to type 2 diabetes mellitus patients, it improves the serum lipid profile, increases the adiponectin level, and decreases blood pressure [ 35 ].…”

Section: Astaxanthin: Biochemistry and Bioactivitiesmentioning

confidence: 99%

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

2018

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Oxidative stress is a major contributor to the pathogenesis of various human diseases as well as to the aging process. Mitochondria, as the center of cellular metabolism and major regulators of redox balance, play a critical role in disease development and progression. Mitochondrial dysfunction involving structural and metabolic impairment is prominent in oxidative stress-related diseases. Increased oxidative stress can damage mitochondria, and subsequent mitochondrial dysfunction generates excesses of mitochondrial reactive oxygen species that cause cellular damage. Mitochondrial dysfunction also activates the mitochondrial apoptotic pathway, resulting in cellular death. Astaxanthin, a red-colored xanthophyll carotenoid, exerts an anti-oxidative and anti-inflammatory effect on various cell lines. In this manner astaxanthin maintains mitochondrial integrity under various pathological conditions. In this review, the inhibitory effects of astaxanthin on oxidative stress-induced mitochondrial dysfunction and related disease development are discussed.

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Section: Astaxanthin: Biochemistry and Bioactivitiesmentioning

confidence: 99%

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

2018

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“…In addition, it has been reported that AST decreases the level of oxidative stress, as indicated by reduced plasma malondialdehyde levels, and reverses age-related changes in the residual skin surface components of middle-aged subjects [43].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Matsumoto

Takuwa

et al. 2020

Biomedicines

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Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin.

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“…Meanwhile, AST inhibits ROS formation and modulates the expression of oxidative stress-responsive enzymes, such as heme oxygenase-1 (HO-1), which is a marker of oxidative stress and a regulatory mechanism involved in cell adaptation against oxidative damage [28]. It has also been reported that AST decreases the level of oxidative stress, as indicated by reduced plasma malondialdehyde levels, and reverses age-related changes in the residual skin surface components of middle-aged subjects [29].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Li¹,

Matsumoto²,

Takuwa³

et al. 2019

Preprint

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Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin, a ketocarotenoid from Haematococcus pluvialis, has been extensively studied with respect to its possible effect on skin health as well as UV protection. In addition, astaxanthin attenuates increases in the generation of reactive oxygen species (ROS) and capillary regression of skeletal muscle. In the present study, we investigated whether astaxanthin would protect UV-induced photoaging and capillary regression in the skin of HR-1 hairless mice. UV induces wrinkle formation, thickness and capillary regression in dermis of hairless mice and the administration of astaxanthin decreased the UV-induced wrinkle formation, skin thickness, and increase in collagen fibers in skin. Astaxanthin supplementation also inhibited the levels of ROS generation and attenuated the decreases in wrinkle formation, thickness and capillary number in the skin. We also found an inverse correlation between wrinkling and capillary number, and the photoaging associated with capillary regression in skin. These results suggest that astaxanthin can protect against photoaging caused by ultraviolet irradiation and the effects of astaxanthin in photoaging inhibition may be associated with the protection of capillary regression in skin.

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Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers

Cited by 57 publications

References 59 publications

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

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