Continuous EEG-fMRI in Pre-Surgical Evaluation of a Patient with Symptomatic Seizures: Bold Activation Linked to Interictal Epileptic Discharges Caused by Cavernoma

Avesani, Mirko; Formaggio, Emanuela; Milanese, F.; Baraldo, Anna; Gasparini, Anna; Cerini, Roberto; Bongiovanni, Luigi Giuseppe; Mucelli, R. Pozzi; Fiaschi, Antonio; Manganotti, Paolo

doi:10.1177/197140090802100205

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Avesani et al (74) analyzed the EEG-fMRI data of a patient with symptomatic epilepsy to find the linkage between the "epileptogenic" zone and the "irritative" zone, which is the meticulous cortical distribution of spikes. They used EEG signals as paradigms in the fMRI study and compared the EEG interictal slow-spiked wave with the normal EEG conditions.…”

Section: Conventional Analysismentioning

confidence: 99%

Localization of Epileptic Foci Based on Simultaneous EEG–fMRI Data

et al. 2021

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Combining functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) enables a non-invasive investigation of the human brain function and evaluation of the correlation of these two important modalities of brain activity. This paper explores recent reports on using advanced simultaneous EEG–fMRI methods proposed to map the regions and networks involved in focal epileptic seizure generation. One of the applications of EEG and fMRI combination as a valuable clinical approach is the pre-surgical evaluation of patients with epilepsy to map and localize the precise brain regions associated with epileptiform activity. In the process of conventional analysis using EEG–fMRI data, the interictal epileptiform discharges (IEDs) are visually extracted from the EEG data to be convolved as binary events with a predefined hemodynamic response function (HRF) to provide a model of epileptiform BOLD activity and use as a regressor for general linear model (GLM) analysis of the fMRI data. This review examines the methodologies involved in performing such studies, including techniques used for the recording of EEG inside the scanner, artifact removal, and statistical analysis of the fMRI signal. It then discusses the results reported for patients with primary generalized epilepsy and patients with different types of focal epileptic disorders. An important matter that these results have brought to light is that the brain regions affected by interictal epileptic discharges might not be limited to the ones where they have been generated. The developed methods can help reveal the regions involved in or affected by a seizure onset zone (SOZ). As confirmed by the reviewed literature, EEG–fMRI provides information that comes particularly useful when evaluating patients with refractory epilepsy for surgery.

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Section: Conventional Analysismentioning

confidence: 99%

Localization of Epileptic Foci Based on Simultaneous EEG–fMRI Data

et al. 2021

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“…The reference was placed anterior to Fz, and the ground posterior to Fz as in other studies [11][12][13][14] using the same system. To ensure subjects' safety, the wires were carefully arranged to avoid loops and physical contact with the subject.…”

Section: Eeg Recordings and Analysismentioning

confidence: 99%

EEG-fMRI Evaluation of Patients with Mesial Temporal Lobe Sclerosis

et al. 2014

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SUMMARY -This preliminary study sought more information on blood oxygen level dependent (BOLD) activation, especially contralateral temporal/extratemporal spread, during continuous EEG-fMRI recordings in four patients with mesial temporal sclerosis (MTS). In two patients, EEG showed unilateral focal activity during the EEG-fMRI session concordant with the interictal focus previously identified with standard and video-poly EEG. In the other two patients EEG demonstrated a contralateral diffusion of the irritative focus. In the third patient (with the most drug-resistant form and also extratemporal clinical signs), there was an extratemporal diffusion over frontal regions, ipsilateral to the irritative focus. fMRI analysis confirmed a single activation in the mesial temporal region in two patients whose EEG showed unilateral focal activity, while it demonstrated a bilateral activation in the mesial

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EEG and fMRI Coregistration to Investigate the Cortical Oscillatory Activities During Finger Movement

et al. 2008

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Electroencephalography combined with functional magnetic resonance imaging (EEG-fMRI) may be used to identify blood oxygenation level dependent (BOLD) signal changes associated with physiological and pathological EEG event. In this study we used EEG-fMRI to determine the possible correlation between topographical movement-related EEG changes in brain oscillatory activity recorded from EEG electrodes over the scalp and fMRI-BOLD cortical responses in motor areas during finger movement. Thirty-two channels of EEG were recorded in 9 subjects during eyes-open condition inside a 1.5 T magnetic resonance (MR) scanner using a MR-compatible EEG recording system. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data during fMRI acquisition. For EEG data analysis we used the event-related-synchronization/desynchronization (ERS/ERD) approach to investigate where movement-related decreases in alpha and beta power are located. For image statistical analysis we used a general linear model (GLM) approach. There was a significant correlation between the positive-negative ratio of BOLD signal peaks and ERD values in the electrodes over the region of activation. We conclude that combined EEG-fMRI may be used to investigate movement-related oscillations of the human brain inside an MRI scanner and the movement-related changes in the EMG or EEG signals are useful to identify the brain activation sources responsible for BOLD-signal changes.

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Continuous EEG-fMRI in Pre-Surgical Evaluation of a Patient with Symptomatic Seizures: Bold Activation Linked to Interictal Epileptic Discharges Caused by Cavernoma

Cited by 7 publications

References 28 publications

Localization of Epileptic Foci Based on Simultaneous EEG–fMRI Data

Localization of Epileptic Foci Based on Simultaneous EEG–fMRI Data

EEG-fMRI Evaluation of Patients with Mesial Temporal Lobe Sclerosis

EEG and fMRI Coregistration to Investigate the Cortical Oscillatory Activities During Finger Movement

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