Continuous Flow Injection Analysis (CFIA) of Metformin Hydrochloride using Microphotmeter Equipped with 530 and 550nm LED.

Shakir, Issam M.A.; Al-abdli, Basim I.; Nafea, Huda M.

doi:10.22401/jnus.16.4.04

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Another different techniques for the determination of MET, which have been described, such as conductometric titration [22]., flow injection and chemiluminescence [23][24][25][26], capillary electrophoresis [27]. Cloud point extraction (CPE), a micellemediated process, has become one of the important separation and preconcentration methods which were improving the sensitivity in determination of trace metal ions and acting as an alternative to liquid-liquid extraction.…”

Section: Introductionmentioning

confidence: 99%

Preconcentration and determination of Metformine Hydrochloride in different samples by cloud point extraction coupling with uv-visible spectrophotometry

Dhabab¹,

Kazar²

2016

Baghdad Sci.J

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This work was influenced the separation and preconcentration steps were carried out to determination of metformin (MET) in pharmaceutical preparations and human serum samples. Complex formation method and cloud-point extraction (CPE) coupling with UV-Visible spectrophotometry were used to investigated of study target.The results has showed the best optical characteristic for calibration curve and statistical data which were obtained under optimum conditions. The first method is based on the reaction of MET with nickel (II) in alkaline medium an absorption maximum ?)max) at 434nm. ''Beer's low'' is obeyed in the concentration range (10-100µg.ml-1) with molar absorptivity of 3.9x103 L.mol-1.cm-1.The limit of detection and quantitation values were 2.37 and7.11 µg.ml-1 respectively. The second method based on extraction of traces amounts of MET using the cloud-point extraction (CPE). This method implicated for using of a nonionic surfactant (Triton x-114) as an extraction medium which was entrap the hydrophobic complex formed between MET and nickel(ii) in basic medium as reaction system for designing the CPE procedure. The optimum conditions were similar the first method expect the amount of surfactant which was 0.5 ml. The concentrations range of calibration curve from 3.5to100 µg.ml-1 and molar absorptivity of 1.2x104 L.mol-1.cm-1. In this method was access to less of concentrations in Limit of detection and quantitation which were 0.74and 2.22 µg.ml-1 respectively. The precise (RSD %) and accuracy (recovery %) of both methods were ranged between 0.24-0.47, 97.86-98.68 respectively. The data of two methods were appeared high acceptable with standered of British Pharmacopoeia through using statistic methods (f-test and t-test), that they may be used in analysis of MET.

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Section: Introductionmentioning

confidence: 99%

Preconcentration and determination of Metformine Hydrochloride in different samples by cloud point extraction coupling with uv-visible spectrophotometry

Dhabab¹,

Kazar²

2016

Baghdad Sci.J

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A Review using continuous flow injection analysis technique in the determination of several drugs

Mezaal,

Kawther Ahmed Sadiq,

Tamara Ahmed Abdel Karim

2024

IHJPAS

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Continuous flow injection analysis (CFIA) is one of the simplest, easiest, and multilateral analytical automation methods in moist chemical analysis. This method depends on changing the physical and chemical properties of a part of the specimen spread out from the specimen injected into the carrier stream. The CFIA technique uses automatic analysis of samples with high efficiency. The CFIA PC compatibility also allows specimens to be treated automatically, reagents to be added, and reaction conditions to be closely monitored. The CFIA is one of the automated chemical analysis methods in which a successive specimen sample is to be estimated and injected into a vector stream from a flowing solution that meets the reagent and mixes at a specific point, the y-junction, before reaching the detector. However, CFIA does not have a separation method because the sample, carrier stream, and reagent all enter the system simultaneously and move together at a specific flow rate to the end of the system. It is also possible to inject a second specimen sample to be estimated before the first sample reaches the detector. For all the reasons mentioned, the CFIA technique analysis is appropriate, fast, and ideal for analyzing different samples. This general technique deals with solutions and is used for various tasks, including pH measurement, conductivity, colorimetry, titration, and enzyme assays. So, it was used in analytical chemistry to estimate many samples, including medicines, because they are essential substances for human life, and everyone widely uses them.

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Continuous Flow Injection Analysis (CFIA) of Metformin Hydrochloride using Microphotmeter Equipped with 530 and 550nm LED.

Cited by 2 publications

References 6 publications

Preconcentration and determination of Metformine Hydrochloride in different samples by cloud point extraction coupling with uv-visible spectrophotometry

Preconcentration and determination of Metformine Hydrochloride in different samples by cloud point extraction coupling with uv-visible spectrophotometry

A Review using continuous flow injection analysis technique in the determination of several drugs

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