2006
DOI: 10.1042/ba20050222
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Continuous hybridoma bioreactor: sensitivity analysis and optimal control

Abstract: Animal cell culture has already established itself as a mature technology able to make a wide range of valuable products, the actual focus being to find the competitive bioreactor design and operating conditions for increasing production. A complex analysis, implying sensitivity calculus and optimal control computation, is done for a system composed of a continuous perfectly mixed bioreactor, with cell recirculation, a cell separator, a mixer and a purge. The bioreactor's sensitivity to the control parameters … Show more

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Cited by 3 publications
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