2011
DOI: 10.1016/j.metabol.2010.08.006
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Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization

Abstract: Objective An adaptation to chronic total parenteral nutrition (TPN; 75% of non protein calories as glucose) is the liver becomes a major consumer of glucose with lactate release as a by-product. The liver is able to further increase liver glucose uptake when a small dose of fructose is acutely infused via the portal system. Glucagon, commonly elevated during inflammatory stress, is a potent inhibitor of glucose uptake by the liver during TPN. The aim was to determine if chronic fructose infusion could overcome… Show more

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Cited by 4 publications
(5 citation statements)
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“…Although correlations do not prove causation, and total sugar consumption has not increased in the last few years (23) and has actually decreased in recent years in the U.S. (24,25), sugar consumption is still at very high levels. Our initial article highlighted the potential importance of fructose in HFCS and SSBs and posited the hypothesis that it could represent a potential pathway for some of the detrimental effects of sugar (26)(27)(28)(29)(30)(31).…”
mentioning
confidence: 99%
“…Although correlations do not prove causation, and total sugar consumption has not increased in the last few years (23) and has actually decreased in recent years in the U.S. (24,25), sugar consumption is still at very high levels. Our initial article highlighted the potential importance of fructose in HFCS and SSBs and posited the hypothesis that it could represent a potential pathway for some of the detrimental effects of sugar (26)(27)(28)(29)(30)(31).…”
mentioning
confidence: 99%
“…An experimental study [ 68 ] performed on dogs subjected to TP analyzed the role of fructose infusion to obtain a glucagon decrease after hepatic glucose uptake. Since fructose stimulates liver glucose uptake, they hypothesize the possibility to limit stress-induced hyperglycemia in fructose-supported patients.…”
Section: Discussionmentioning
confidence: 99%
“…Prior work showed that the hepatic response to enteral and parenteral nutrient delivery was similar [3] , [4] . Free ends of the catheters, and flow probes were exteriorized and placed in subcutaneous pockets [8] . After removal of the pancreas, dogs were treated with subcutaneous injections of regular (Eli Lilly, Indianapolis, IN) and NPH (intermediate-acting) insulin daily until a continuous infusion of nutrition was initiated.…”
Section: Methodsmentioning
confidence: 99%