Continuous midazolam infusion can minimize the pro-inflammatory response to anesthesia and surgery for pediatric patients with intra-abdominal infection: Comparative study versus continuous propofol infusion

Lotfy, Mohamed; Ayaad, Mohamed G.; Elsawaf, Mohamed; Atyia, Gehan F.

doi:10.1080/11101849.2021.1955532

Cited by 1 publication

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“…A recent 2021 study by Lotfy et al [ 5 ] on a population of pediatric patients with intra-abdominal infection showed that the infusion of Midazolam and not Propofol decreases serum cytokine levels. A series of studies by Lisowska et al [ 9 ] and Marik [ 44 ] have shown that Propofol decreases serum concentrations of IL-1, TNF- α , and IL-6 and increases the concentration of IL-10, so this anesthetic drug may have antioxidant and anti-inflammatory properties.…”

Section: ⧉ Discussionmentioning

confidence: 99%

“…As an anesthetic drug, Midazolam is used in premedication and procedural sedation. Midazolam can minimize the proinflammatory response to anesthesia [ 5 ]. It seems that Midazolam can induce apoptosis and can suppress the progression of cancer cells, having antitumorigenic properties, which should be considered in choosing the anesthetic drug [ 6 ].…”

Section: ⧉ Introductionmentioning

confidence: 99%

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The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

Novac

Boldeanu²,

Rotaru³

et al. 2022

Rom J Morphol Embryol

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Background : The specific mechanism of action of each anesthetic drug on the immune system is still incompletely known. It is important to know how the various anesthetics used in minimally invasive surgery (MIS) act on the inflammatory response because the choice of the anesthetic agent can influence the patient’s immune system. Aim : Evaluation of the effect of anesthetic drugs used for total intravenous anesthesia (Propofol and Midazolam) on the inflammatory response after minimally invasive gynecological surgery. Patients, Materials and Methods : The inflammatory response in 20 female patients who underwent minimally invasive gynecological surgery under which intravenous anesthesia was performed. Depending on the combination of anesthetics used, we subdivided the study group into two groups, Group 1 consisting of the patients ( n =10) who were given for total intravenous anesthesia, the combination with Midazolam+Fentanyl, and Group 2 ( n =10) the patients who received the combination of Propofol+Fentanyl, respectively. Surgical interventional procedures included day surgery: diagnostic and operative hysteroscopy, endometrial ablation, surgical treatment of vulvar disorders. Serological profiling of patients was performed by dosing the serum concentration of nucleotide-binding domain (NOD) and leucine-rich repeat protein 3 (NLRP3) inflammasomes, interleukin (IL)-6, tumor necrosis factor-alpha (TNF- α ), IL-10 before and two hours after the surgical procedure. Results : In our study, we found that in both groups of patients (Midazolam+Fentanyl – Group 1, Propofol+Fentanyl – Group 2), NLRP3 and cytokines concentrations in the serum were higher after MIS than those before MIS. Conclusions : It appears that both Midazolam and Fentanyl and Propofol and Fentanyl have an immunomodulatory action due to the anti-inflammatory effect of both anesthetics. Therefore, anesthesiologists must choose an anesthetic method that uses individualized anesthetic agents, depending on the patient’s immune status and disease.

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Section: ⧉ Discussionmentioning

confidence: 99%

Section: ⧉ Introductionmentioning

confidence: 99%

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

Novac

Boldeanu²,

Rotaru³

et al. 2022

Rom J Morphol Embryol

View full text Add to dashboard Cite

show abstract

Continuous midazolam infusion can minimize the pro-inflammatory response to anesthesia and surgery for pediatric patients with intra-abdominal infection: Comparative study versus continuous propofol infusion

Abstract: F. Atyia (2021) Continuous midazolam infusion can minimize the pro-inflammatory response to anesthesia and surgery for pediatric patients with intra-abdominal infection: Comparative study versus continuous propofol infusion,

Cited by 1 publication

References 35 publications

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

The perioperative effect of anesthetic drugs on the immune response in total intravenous anesthesia in patients undergoing minimally invasive gynecological surgery

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