Continuous Plasma Exchange With Dialysis for Severe Sepsis: Case Series of a Novel Blood Purification Method

Satoh, Kasumi; Okuyama, Manabu; Irie, Yasuhito; Kitamura, Toshiharu; Nakae, Hajime

doi:10.7759/cureus.12495

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Furthermore, it was reported that PE was not associated with any survival benefit [ 93 ]. Recently, a case report on the use of a new technique, i.e., continuous PE in combination with dialysis in the management of sepsis, was published; this may represent a new approach for investigating the feasibility of PE in the treatment of sepsis [ 94 ]. Nonetheless, the latest update of the Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 does not recommend the use of PE in the management of sepsis due to insufficient evidence [ 95 ].…”

Section: Plasma Exchange In the Treatment Of Septic Akimentioning

confidence: 99%

Renal Replacement Techniques in Septic Shock

Hellman

Uusalo

Järvisalo

2021

IJMS

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Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection; it carries a risk for mortality, considerably exceeding that of a mere infection. Sepsis is the leading cause for acute kidney injury (AKI) and the requirement for renal replacement therapy (RRT) in intensive care unit (ICU) patients. Almost every second critically ill patient with sepsis will develop AKI. In septic shock, the dysregulated host response to infectious pathogens leads to a cytokine storm with uncontrolled production and release of humoral proinflammatory mediators that evoke cellular toxicity and promote the development of organ dysfunction and increased mortality. In addition to treating AKI, RRT techniques can be employed for extracorporeal adsorption of inflammatory mediators using specifically developed adsorption membranes, hemoperfusion sorbent cartridges or columns; these techniques are intended to decrease the level and early deleterious effects of circulating proinflammatory cytokines and endotoxins during the first hours and days of septic shock treatment, in order to improve patient outcomes. Several methods and devices, such as high cut-off membranes, the Oxiris®-AN69 membrane, CytoSorb® and HA380 cytokine hemoadsorption, polymyxin B endotoxin adsorption, and plasmapheresis have been examined in small study series or are under evaluation as ways of improving patient outcomes in septic shock. However, to date, the data on actual outcome benefits have remained controversial, as discussed in this review.

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Section: Plasma Exchange In the Treatment Of Septic Akimentioning

confidence: 99%

Renal Replacement Techniques in Septic Shock

Hellman

Uusalo

Järvisalo

2021

IJMS

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Relationship between septic acute kidney injury and adiponectin: A retrospective study in patients undergoing continuous plasma exchange with dialysis

Yoshida,

Nakae,

Satoh

et al. 2024

Ther Apher Dial

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IntroductionAdiponectin (APN) is a multimeric protein with anti‐inflammatory properties that is specifically secreted by adipocytes. Continuous plasma exchange with dialysis (cPED) is a blood purification therapy in which plasma exchange is performed using a selective membrane plasma separator while the dialysate flows outside the hollow fibers.MethodsPatients with sepsis were divided into two groups based on the presence or absence of acute kidney injury (AKI) complications: AKI and non‐AKI group.ResultsPlasma APN levels significantly increased after cPED in both groups. The creatinine levels in the AKI group before cPED were significantly higher than those in the non‐ AKI group. The plasma APN levels in the AKI group before cPED were significantly higher than those in the non‐AKI group.ConclusioncPED increased APN levels in both patients with and without AKI. Therefore, cPED therapy may be a promising intervention for increasing APN levels in patients with sepsis.

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Continuous Plasma Exchange With Dialysis for Severe Sepsis: Case Series of a Novel Blood Purification Method

Cited by 2 publications

References 16 publications

Renal Replacement Techniques in Septic Shock

Renal Replacement Techniques in Septic Shock

Relationship between septic acute kidney injury and adiponectin: A retrospective study in patients undergoing continuous plasma exchange with dialysis

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