Continuous positive airway pressure and body position alter lung clearance of the radiopharmaceutical 99mtechnetium-diethylenetriaminepentaacetic acid (99mTc-DTPA)

Paiva, Dulciane Nunes; Masiero, Paulo Ricardo; Spiro, Bernardo Leão; Jost, Renan Trevisan; Albuquerque, Isabella Martins de; Cardoso, Dannuey Machado; Andrade, Armele F. D.; Missailidis, Sotiris; Santos-Filho, Sebastião David; Bernardo-Filho, Mário; Bajc, Marika; Menna-Barreto, Sérgio Saldanha

doi:10.5897/ajb12.2563

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…Our findings differ from those reported by Paiva et al, 18 who assessed the permeability of the alveolar epithelial membrane in 36 healthy individuals submitted to 10 cmH 2 O and 20 cmH 2 O under continuous positive airway pressure (CPAP). The authors showed that 20 cmH 2 O of CPAP induced an increase in epithelial permeability, whereas 10 cmH 2 O of CPAP did not.…”

Section: Discussioncontrasting

confidence: 99%

Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals

et al. 2016

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Objective: To evaluate the effects of positive expiratory pressure (PEP) on pulmonary epithelial membrane permeability in healthy subjects. Methods: We evaluated a cohort of 30 healthy subjects (15 males and 15 females) with a mean age of 28.3 ± 5.4 years, a mean FEV 1 /FVC ratio of 0.89 ± 0.14, and a mean FEV 1 of 98.5 ± 13.1% of predicted. Subjects underwent technetium-99m-labeled diethylenetriaminepentaacetic acid ( 99m Tc-DTPA) radioaerosol inhalation lung scintigraphy in two stages: during spontaneous breathing; and while breathing through a PEP mask at one of three PEP levels-10 cmH 2 O (n = 10), 15 cmH 2 O (n = 10), and 20 cmH 2 O (n = 10). The 99mTc-DTPA was nebulized for 3 min, and its clearance was recorded by scintigraphy over a 30-min period during spontaneous breathing and over a 30-min period during breathing through a PEP mask. Results: The pulmonary clearance of 99m Tc-DTPA was significantly shorter when PEP was applied-at 10 cmH 2 O (p = 0.044), 15 cmH 2 O (p = 0.044), and 20 cmH 2 O (p = 0.004)-in comparison with that observed during spontaneous breathing. Conclusions: Our findings indicate that PEP, at the levels tested, is able to induce an increase in pulmonary epithelial membrane permeability and lung volume in healthy subjects.

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Section: Discussioncontrasting

confidence: 99%

Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals

et al. 2016

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“…As seen in Table 3, nebulised 99m Tc-DTPA is mainly used to investigate the effect of particular pulmonary delivery equipment, e.g. positive expiratory pressure device, on the aerosol performance of lung deposition [97,[100][101][102][103][104][105]. Other studies with 99m Tc-DTPA focus on distinguishing different lung diseases [74,106,107], understanding the physiology of lung disease [108], and investigating the new application of ventilation scintigraphy [109].…”

Section: Nebulisationmentioning

confidence: 99%

Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging

Munir¹,

Setiawan²,

Awaludin³

et al. 2022

Clin Transl Imaging

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Purpose The application of contrast and tracing agents is essential for lung imaging, as indicated by the wide use in recent decades and the discovery of various new contrast and tracing agents. Different aerosol production and pulmonary administration methods have been developed to improve lung imaging quality. This review details and discusses the ideal characteristics of aerosol administered via pulmonary delivery for lung imaging and the methods for the production and pulmonary administration of dry or liquid aerosol. Methods We explored several databases, including PubMed, Scopus, and Google Scholar, while preparing this review to discover and obtain the abstracts, reports, review articles, and research papers related to aerosol delivery for lung imaging and the formulation and pulmonary delivery method of dry and liquid aerosol. The search terms used were "dry aerosol delivery", "liquid aerosol delivery", "MRI for lung imaging", "CT scan for lung imaging", "SPECT for lung imaging", "PET for lung imaging", "magnetic particle imaging", "dry powder inhalation", "nebuliser", and "pressurised metered-dose inhaler". Results Through the literature review, we found that the critical considerations in aerosol delivery for lung imaging are appropriate lung deposition of inhaled aerosol and avoiding toxicity. The important tracing agent was also found to be Technetium-99m ( 99m Tc), Gallium-68 ( 68 Ga) and superparamagnetic iron oxide nanoparticle (SPION), while the essential contrast agents are gold, iodine, silver gadolinium, iron and manganese-based particles. The pulmonary delivery of such tracing and contrast agents can be performed using dry formulation (graphite ablation, spark ignition and spray dried powder) and liquid aerosol (nebulisation, pressurised metered-dose inhalation and air spray). Conclusion A dual-imaging modality with the combination of different tracing or contrast agents is a future development of aerosolised micro and nanoparticles for lung imaging to improve diagnosis success.

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Continuous positive airway pressure and body position alter lung clearance of the radiopharmaceutical 99mtechnetium-diethylenetriaminepentaacetic acid (99mTc-DTPA)

Cited by 2 publications

References 40 publications

Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals

Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals

Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging

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