Continuous-processing-related event-related potentials in children with attention deficit hyperactivity disorder

Strandburg, Robert J.; Marsh, James T.; Brown, Warren S.; Asarnow, Robert F.; Higa, Jerilyn; Harper, R. Andrew; Guthrie, Donald

doi:10.1016/0006-3223(95)00545-5

Cited by 90 publications

(72 citation statements)

References 36 publications

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“…Neurophysiological studies have implicated an ensemble of thalamocortical structures involved in CNV generation including the dorsal anterior cingulate cortex, frontal cortex, thalamus, and midbrain dopaminergic nuclei involved in CNV generation [62][63][64]. Numerous studies have demonstrated that CNV amplitude may be reduced in ADHD [56,[65][66][67][68] and may represent a persistent deficit in patients with ADHD [69••], although there have also been some negative findings [58,70,71].…”

Section: Psychophysiological Characteristicsmentioning

confidence: 99%

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ADHD History of the Concept: the Case of the Continuous Performance Test

Albrecht

Sandersleben

Wiedmann

et al. 2015

Curr Dev Disord Rep

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The historic development of the attention deficit hyperactivity disorder (ADHD) construct is, in many cases, paralleled by research questions addressed with the continuous performance test (CPT). This task, the use of which dates back to the 1950s for the diagnosis of brain damage, requires responding to rare targets in a sequence of stimuli during prolonged assessment. In our review, we illustrate how the CPT was and still is used for the assessment of sustained attention and impulsivity as core features of ADHD. In addition to impaired performance at the neuropsychological level, the CPT also taps underlying brain activity that can be registered by neuroimaging techniques such as fMRI and EEG. The latter allows more detailed operationalization of ADHD theories, and reveals impairments at different stages of information processing. The CPT has also been applied for treatment evaluation. Recently, distinct genetic effects on preparation and response control or impulsivity were detected using the CPT. As such, the task remains a valuable tool for further investigations of genetic and environmental factors of ADHD.

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Section: Psychophysiological Characteristicsmentioning

confidence: 99%

“…Explicit analyses of Go-P3 evoked by the CPT in ADHD are rare, but some instances of diminished amplitude in patients have been observed [70,72,88,89].…”

Section: Psychophysiological Characteristicsmentioning

confidence: 99%

ADHD History of the Concept: the Case of the Continuous Performance Test

Albrecht

Sandersleben

Wiedmann

et al. 2015

Curr Dev Disord Rep

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“…Explicit analyses of the Go-P3 in ADHD are rare, but some instances of diminished amplitude for patients have been seen (Strandburg et al 1996 ;Overtoom et al 1998 ;Banaschewski et al 2004 ;Lawrence et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

et al. 2012

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BACKGROUND: Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD. Method Preparation and response control were assessed using behavioural and electrophysiological parameters of two versions of a cued continuous performance test with varying attentional load in boys with ADHD combined type (n = 97), their non-affected siblings (n = 27) and control children without a family history of ADHD (n = 43). RESULTS: Children with ADHD and non-affected siblings showed more variable performance and made more omission errors than controls. The preparatory Cue-P3 and contingent negative variation (CNV) following cues were reduced in both ADHD children and their non-affected siblings compared with controls. The NoGo-P3 was diminished in ADHD compared with controls whilst non-affected siblings were located intermediate but did not differ from both other groups. No clear familiality effects were found for the Go-P3. Better task performance was further associated with higher CNV and P3 amplitudes. CONCLUSIONS: Impairments in performance and electrophysiological parameters reflecting preparatory processes and to some extend also for inhibitory response control, especially under high attentional load, appeared to be familially driven in ADHD and may thus constitute functionally relevant endophenotypes for the disorder. Background. Patients with attention deficit-hyperactivity disorder (ADHD) exhibit difficulties in multiple attentional functions. Although high heritability rates suggest a strong genetic impact, aetiological pathways from genes and environmental factors to the ADHD phenotype are not well understood. Tracking the time course of deviant task processing using event-related electrophysiological brain activity should characterize the impact of familiality on the sequence of cognitive functions from preparation to response control in ADHD.

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“…Also, it could be the reflection of a contingent negative variation triggered by the warning signal itself. Earlier reports seem to offer support for any one of these notions (Strandburg et al, 1996;González-Garrido et al, 2001). Whatever the theoretical alternative might be, they all do seem to point to the probable failure of the injured children to efficiently use relevant contextual information.…”

Section: Discussionmentioning

confidence: 98%

Event-Related Brain Potentials Depict Cognitive Disturbances in Children with Mild Traumatic Brain Injury

González-Garrido¹,

González-González

Gómez-Velázquez³

et al. 2013

IJPS

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Mild traumatic brain injury (MTBI) is a common cause of short-term cognitive disturbances in children that rarely are related to objective neurophysiological markers. With the aim of correlating cognitive processing with event-related brain potential variation, visual Continuous Performance Tests (CPT) were administered to 15 children with MTBI and a matched control group. All the patients had suffered post-traumatic loss of consciousness lasting less than 15 minutes, and they were evaluated within 5-to-15 days post-trauma. A few additional neuropsychological tests were also administered to both groups. Behavioral results showed that the injured children achieved poorer scores for phonological and verbal fluency tasks and no interference effect in a computerized version of the Stroop test. They had fewer correct responses on CPT-AX, where a warning signal preceded targets. The N90, P240 and P390 ERP components varied significantly between groups while performing CPT-AX. Present findings could be interpreted as reflecting disturbances that impede injured children from using contextual information efficiently. The higher amplitude of the slow late positivity observed in the control group might reflect updating memory preparatory processes that could increase subsequent cognitive operational competence. The ERP assessment could be helpful to demonstrate early neurophysiological disturbances subsequent to a MTBI in children.

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Continuous-processing-related event-related potentials in children with attention deficit hyperactivity disorder

Cited by 90 publications

References 36 publications

ADHD History of the Concept: the Case of the Continuous Performance Test

ADHD History of the Concept: the Case of the Continuous Performance Test

Familiality of neural preparation and response control in childhood attention deficit-hyperactivity disorder

Event-Related Brain Potentials Depict Cognitive Disturbances in Children with Mild Traumatic Brain Injury

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