Continuous renal replacement therapy to reduce inflammation in a piglet hemorrhage–reperfusion extracorporeal membrane oxygenation model

Mu, Thornton; Palmer, Eldon; Batts, Sherreen; Lentz-Kapua, Sarah; Uyehara-Lock, Jane; Uyehara, Catherine F. T.

doi:10.1038/pr.2012.69

Cited by 24 publications

(16 citation statements)

References 28 publications

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“…In 15 newborn patients matched with 46 controls, such addition of CRRT to the ECMO circuit improved outcomes by reducing time on ECMO and on ventilation as well as improving fluid balance management [43]. Similarly, animal models of ECMO have suggested there may be a direct protective effect from CRRT with reduced inflammatory markers, improvement of mean perfusion pressure, systemic vascular resistance and oxygen delivery [46]. However, CRRT might increase the risk of ECMO oxygenator failure.…”

Section: Key Findingsmentioning

confidence: 99%

Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation

et al. 2014

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Section: Key Findingsmentioning

confidence: 99%

Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation

et al. 2014

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“…It is crucial in the acute-phase inflammatory response and is relevant to the inducers of cardiovascular disease [19]. CRRT may decrease inflammatory cytokine levels for patients with severe AKI [16]. In this study, the pro-inflammatory cytokines TNF-α and IL-6 were significantly reduced in the survival group compared with the non-survival group.…”

Section: Discussionmentioning

confidence: 61%

“…Many studies have shown that levels of serum cytokines, such as TNF-α and IL-6, are increased in patients with severe AKI [14–16]. Pro-inflammatory cytokines may contribute to additional organ dysfunction, which is associated with high mortality [17].…”

Section: Discussionmentioning

confidence: 99%

Effects of continuous renal replacement therapy on serum cytokines, neutrophil gelatinase-associated lipocalin, and prognosis in patients with severe acute kidney injury after cardiac surgery

Wang

et al. 2016

Oncotarget

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The aim of our study was to evaluate the effect of continuous renal replacement therapy (CRRT) on serum cytokines, neutrophil gelatinase-associated lipocalin (NGAL), and prognosis in patients with severe acute kidney injury (AKI) following cardiac surgery. A total number of 153 patients with severe AKI following cardiac surgery were treated with CRRT. They were divided into the survival and non-survival groups. Clinical data from these two groups before and after CRRT were recorded and analyzed. It was found that the number of impaired organs, MODS and APACHE II scores were significantly higher in the non-survival group than those in the survival group before CRRT. After CRRT, MODS and APACHE II scores decreased significantly. The post-CRRT levels of serum TNF-a and IL-6 were significantly decreased. After CRRT, serum NGAL decreased in the two groups, but the levels were higher in the non-survival group than those in the survival group. MODS and APACHE II scores could be used to evaluate the severity of AKI in patients after cardiac surgery. CRRT is an effective treatment for these patients and high levels of TNF-a, IL-6, and NGAL are associated with a poor prognosis in these patients.

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“…The membrane, which can also be used under hypotension, causes a weak activation of complement and leukocytes, and has a small impact on hemodynamics. The high-permeability of this membrane may help to improve the anti-inflammatory cytokine to proinflammatory cytokine ratio, down-regulate the body's inflammatory response, and ameliorate the systemic inflammatory response (8).…”

Section: Discussionmentioning

confidence: 99%

Continuous renal replacement therapy in children with multiple organ dysfunction syndrome: A case series

Zhang

Zhou

et al. 2014

Int. braz j urol.

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ARTICLE INFO ______________________________________________________________ ______________________There is a lack of definitive information regarding the precise indications, implementation, and outcomes of continuous renal replacement therapy (CRRT) for the treatment of critically ill children. Six children (three boys, three girls) aged from 3 days to 8 years, all of whom had multiple organ failure, were submitted to bedside CRRT using M60 filter membranes. Modified Port carbonate formula was used and clotting time was maintained between 20 and 30 minutes. Activated partial thromboplastin time was 1.5-to 2-fold normal. One patient discontinued treatment due to family decision. Marked improvements were seen in the remaining five patients, including normalization of blood urea nitrogen and creatinine levels, stabilization of electrolytes, and improvements in markers of organ function. Of note, one patient (a six-year-old male) underwent the treatment for 241 hours. All five patients were subsequently discharged and recovered uneventfully. CRRT is effective for the management of children who are critically ill due to multiple organ failure.

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Continuous renal replacement therapy to reduce inflammation in a piglet hemorrhage–reperfusion extracorporeal membrane oxygenation model

Cited by 24 publications

References 28 publications

Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation

Impact of fluid balance on outcome of adult patients treated with extracorporeal membrane oxygenation

Effects of continuous renal replacement therapy on serum cytokines, neutrophil gelatinase-associated lipocalin, and prognosis in patients with severe acute kidney injury after cardiac surgery

Continuous renal replacement therapy in children with multiple organ dysfunction syndrome: A case series

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