2019
DOI: 10.1016/j.chest.2018.09.004
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Continuous Renal Replacement Therapy

Abstract: Continuous renal replacement therapy (CRRT) is commonly used to provide renal support for critically ill patients with acute kidney injury, particularly patients who are hemodynamically unstable. A variety of techniques that differ in their mode of solute clearance may be used, including continuous venovenous hemofiltration with predominantly convective solute clearance, continuous venovenous hemodialysis with predominantly diffusive solute clearance, and continuous venovenous hemodiafiltration, which combines… Show more

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Cited by 233 publications
(287 citation statements)
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References 99 publications
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“…Acute RRT is required GFR in cases of AKI presenting with refractory volume overload, intractable metabolic acidosis and hyperkalemia, and uremia [2][3][4]. However, in cases of severe AKI, RRT is often initiated before the onset of these conventional indications for RRT.…”
Section: Indications For Crrt In the Elderlymentioning
confidence: 99%
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“…Acute RRT is required GFR in cases of AKI presenting with refractory volume overload, intractable metabolic acidosis and hyperkalemia, and uremia [2][3][4]. However, in cases of severe AKI, RRT is often initiated before the onset of these conventional indications for RRT.…”
Section: Indications For Crrt In the Elderlymentioning
confidence: 99%
“…At present, the Kidney Disease Improving Global Outcomes (KDIGO) recommends delivering an effluent volume of 20 to 25 mL/kg/hr [2]. However, the actual dose delivered may be substantially lower than the prescribed dose due to filter fouling and interruptions during CRRT, such as circuit changes and clotting [4]. Hence, attention should be paid to the actual delivered dose, particularly in the elderly because of their typically lower BMI and altered body composition (Fig.…”
Section: Timing and Dosage Of Crrt In The Elderlymentioning
confidence: 99%
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“…CRRT is a mode of renal replacement therapy for hemodynamically unstable, fluid overloaded patients and the patients with sepsis and septic shock in management of ARF, especially in the ICU setting [19] . CRRT initiated for ARF in critically ill patients should serve as a renal 'replacement' therapy mimicking as artificial kidney support.…”
Section: Discussionmentioning
confidence: 99%
“…The other three modalities are continuous veno-venous hemofiltration (CVVH) (convection), continuous veno-venous hemodialysis (CVVHD) (diffusion) and continuous veno-venous hemodiafiltration (CVVHDF) (diffusion and convection) [163][164][165][166]. Peritoneal dialysis, a slow efficient continuous modality is an acceptable alternative to extra corporeal modalities [167]. Intermittent hemodialysis (iHD) is routinely prescribed for 3 to 4 h three times a week and supports rapid clearances of small molecules and toxic drugs [168].…”
Section: Management Of Akimentioning
confidence: 99%