ContributorsZG and YL made substantial contributions to the study concept and design. LW was in charge of the manuscript draft. XL, CH, SY and DL took responsibility for obtaining written consent from patients, obtaining ethical approval, collecting samples, and confirming data accuracy. LW and ZG participated in drafting the manuscript, and revising it on the basis of reviewers' comments. LW made substantial contributions to data acquisition, analysis, and interpretation.
Declaration of interestsWe declare no competing interests.
Data sharingWith the permission of the corresponding authors, we can provide participant data without names and identifiers, but not the study protocol, statistical analysis plan, or informed consent form. Data can be provided after the Article is published. Once the data can be made public, the research team will provide an email address for communication. The corresponding authors have the right to decide whether to share the data or not based on the research objectives and plan provided.All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.