Continuous versus bolus intermittent intragastric tube feeding for preterm and low birth weight infants with gastro-oesophageal reflux disease

Richards, Robyn; Foster, Jann P; Psaila, Kim

doi:10.1002/14651858.cd009719.pub3

Cited by 3 publications

(2 citation statements)

References 65 publications

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“…The higher proportion of breast-fed infants in the control group and higher proportion of formula fed infants in the reflux group (Table 1) is consistent with the significantly positive role of breastfeeding for the digestive health infants, as reported in other studies (29). Further, the prevalence of reflux in our study cohort is positively correlated with prematurity and lower birth weight consistent with previously published data (30). In addition, the majority of infants with reflux in this study were previously exposed to either solid food (cereal) or an H2-antagonist medication (Table 1).…”

Section: Discussionsupporting

confidence: 92%

Gastroesophageal reflux and PPI exposure alter gut microbiota in very young infants

Francis,

Chawla,

LaComb

et al. 2023

Front. Pediatr.

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ImportanceInfants with symptomatic Gastroesophageal reflux are treated with pharmacological therapy that includes proton pump inhibitors (PPI) with clinical improvement. The alterations to gut microbiome profiles in comparison to infants without reflux is not known.ObjectiveTo determine the effect of PPI therapy on gut bacterial richness, diversity, and proportions of specific taxa in infants when compared to infants not exposed to acid suppressive therapy.Design, setting, and participantsThis cohort study was conducted at the Stony Brook Hospital in Stony Brook, NY between February 2016, and June 2019. Infants meeting inclusion criteria were enrolled in a consecutive fashion.ResultsA total of 76 Infants were recruited and 60 were enrolled in the study, Twenty nine infants met clinical criteria for reflux and were treated with PPI therapy: median [IQR] gestation: 38.0 weeks [34.7–39.6 weeks]; median [IQR] birthweight: 2.95 Kg [2.2–3.4]; 14 [46.7%] male) and 29 infant were healthy controls median [IQR] gestation: 39.1 weeks [38–40 weeks]; median [IQR] birthweight: 3.3 Kg [2.2–3.4]; 17 [58.6%] male); 58 stool samples from 58 infants were analyzed. There were differences in Shannon diversity between the reflux and control groups. The reflux group that was exposed to PPI therapy had increased relative abundance of a diverse set of genera belonging to the phylum Firmicutes. On the other hand, the control group microbiota was dominated by Bifidobacterium, and a comparatively lower level of enrichment and abundance of microbial taxa was observed in this group of infants.Conclusions and relevanceWe observed significant differences in both α- and β-diversity of the microbiome, when the two groups of infants were compared. The microbiome in the reflux group had more bacterial taxa and the duration of PPIs exposure was clearly associated with the diversity and abundance of gut microbes. These findings suggest that PPI exposure among infants results in early enrichment of the intestinal microbiome.

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Section: Discussionsupporting

confidence: 92%

Gastroesophageal reflux and PPI exposure alter gut microbiota in very young infants

Francis,

Chawla,

LaComb

et al. 2023

Front. Pediatr.

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“…Gastric residual volume when increased, it is considered an indication of infants' feeding intolerance which is thought to be the initial phase of necrotizing enterocolitis, a condition that contributes to low-birth-weight infant deaths. Therefore, one of the key interventions for preventing the consequences of feeding intolerance, necrotizing enterocolitis and aspiration is selecting the gavage feeding technique that is most appropriate for infants (Richards, et al, 2021). Hence, this study aimed to evaluate the effect of nurses' performance regarding gravity gavage and injection force ways on gastric residual volume of preterm infants.…”

Section: )mentioning

confidence: 99%

Nurses' Performance Regarding Gravity Gavage Way Versus Injection Force on Gastric Residual Volume Among Preterm Infants in NICU

Mohamed Mostafa,

Abd-El-Aziz Abd-El-Salam,

Gamal Mohamed

2024

Journal of Nursing Science Benha University

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Background: Gavage feeding is a common method of feeding preterm infants due to their immature sucking reflex. Gavage feeding performed on preterm infants in different ways, including continuous and intermittent bolus gavage, by using force of gravity or injection with a syringe Aim: evaluate the effect of nurses' performance regarding gravity gavage and injection force ways on gastric residual volume.

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Advances in Enteral Nutrition Strategies for Preterm Infants

Hu,

Zhu

2024

JBM

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Continuous versus bolus intermittent intragastric tube feeding for preterm and low birth weight infants with gastro-oesophageal reflux disease

Cited by 3 publications

References 65 publications

Gastroesophageal reflux and PPI exposure alter gut microbiota in very young infants

Gastroesophageal reflux and PPI exposure alter gut microbiota in very young infants

Nurses' Performance Regarding Gravity Gavage Way Versus Injection Force on Gastric Residual Volume Among Preterm Infants in NICU

Advances in Enteral Nutrition Strategies for Preterm Infants

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