"Contractile Interstitial Cells" in Pulmonary Alveolar Septa: A Possible Regulator of Ventilation/Perfusion Ratio?

Kapançi, Y; A, Assimacopoulos; Irlé, C; Zwahlen, A; Gabbiani, Giulio

doi:10.1083/jcb.60.2.375

Cited by 316 publications

(133 citation statements)

References 37 publications

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“…[16][17][18] In keeping with these earlier reports, a-smooth muscle actin-positive cells were only rarely seen within the normal alveolar septa in our analysis. a-smooth muscle actin staining of small sized pure bronchioloalveolar carcinoma is shown in Figure 1.…”

Section: Characteristics Of Subepithelial Myofibroblastssupporting

confidence: 93%

Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis

et al. 2009

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We report here the presence of subepithelial myofibroblasts in pure bronchioloalveolar carcinoma and a subset of invasive lung adenocarcinoma. The subepithelial myofibroblasts we describe were observed in a peculiar location beneath the cancer cells in the alveolar septa. Immunohistochemically, they were positive for a-smooth muscle actin and calponin, but negative for desmin and h-caldesmon. To gain insight into their biological significance, we examined 116 surgically resected lung adenocarcinomas. The resected tumors included 13 bronchioloalveolar carcinomas, 20 mixed type adenocarcinomas with bronchioloalveolar carcinoma components, 57 papillary adenocarcinomas, 22 solid adenocarcinomas with mucin, and 4 acinar adenocarcinomas. All specimens were immunostained for a-smooth muscle actin to visualize the myofibroblasts. In all of the pure bronchioloalveolar carcinomas observed, the subepithelial myofibroblasts were completely preserved adjacent to the cancer cells. In mixed adenocarcinomas with bronchioloalveolar carcinoma components, subepithelial myofibroblasts were present in the bronchioloalveolar carcinoma components, but scanty in the invasive areas, where stromal myofibroblasts emerged between the cancer cell nests. Subepithelial myofibroblasts were retained, however, in the invasive areas of a subset of invasive adenocarcinomas. Survival analysis showed that the retention of subepithelial myofibroblasts in these invasive tumors was associated with low rates of lymphatic and vascular invasion, a low rate of lymph node involvement, and an excellent patient survival. These results suggest that subepithelial myofibroblasts increase in bronchioloalveolar carcinomas, but are gradually replaced by typical stromal myofibroblasts during progression into invasive cancer. A subset of invasive adenocarcinomas retains subepithelial myofibroblasts. Analysis of subepithelial myofibroblasts may be helpful in identifying a subset of lung adenocarcinoma with excellent prognosis.

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Section: Characteristics Of Subepithelial Myofibroblastssupporting

confidence: 93%

Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis

et al. 2009

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“…In the lung, these cells have also been given the term "contractile interstitial cells" (Kapanci et al, 1974). as they have been shown to possess contractile properties ( Evans et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Distribution of transforming growth factor-beta 1, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats.

Perdue¹,

Brody²

1994

J Histochem Cytochem.

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We are studying the development of fibtogenic lesions in the lungs of rats exposed briedly to an aerosol of chrysotile asbestos fibers. This model of asbestosis has enabled us to establish very early cellular events at the specifc locations where interstitial fib& will develop. These sites, the fust alveolar duct bifurcations, are where the fibers are hitially deposited and where macrophages fmt accumulate. In the niques to show that these macrophages exhibit strong localization of transforming growth factor-b. In the adjacent destudiesptesentedhere, ~usedi"t~10hkt0chemicaltec.h-

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“…The type 1 cells line the entire alveolar epithelial surface and run adjacent to capillaries in the underlying mesenchyme, providing a minimal barrier for gas exchange. The mesenchyme of the alveoli also contains alveolar smooth muscle cells and stromal fibroblasts, including lipofibroblasts and myofibroblasts, although these cell types may be interconvertible (Kapanci et al, 1974;Lindahl et al, 1997;McGowan et al, 2008;Perl and Gale, 2009). In all regions of the lung, it is difficult to distinguish the different mesenchymal cells, either morphologically or with molecular markers, and there may be additional undescribed subtypes.…”

Section: Lung Structurementioning

confidence: 99%

The building blocks of mammalian lung development

Rawlins

2010

Developmental Dynamics

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Progress has recently been made in identifying progenitor cell populations in the embryonic lung. Some progenitor cell types have been definitively identified by lineage-tracing studies. However, others are not as well characterized and their existence is inferred on the basis of lung morphology, or mutant phenotypes. Here, I focus on lung development after the specification of the initial lung primordium. The evidence for various lung embryonic progenitor cell types is discussed and future experiments are suggested. The regulation of progenitor proliferation in the embryonic lung, and its coordinate control with morphogenesis, is also discussed. In addition, the relationship between embryonic and adult lung progenitors is considered. Developmental Dynamics 240:463-476,

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"Contractile Interstitial Cells" in Pulmonary Alveolar Septa: A Possible Regulator of Ventilation/Perfusion Ratio?

Abstract: INTRODUCTION

Cited by 316 publications

References 37 publications

Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis

Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis

Distribution of transforming growth factor-beta 1, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats.

The building blocks of mammalian lung development

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