Contralateral esophageal sparing technique in definitive radiotherapy for non-small cell lung cancer: dosimetric parameters and normal tissue complication probability modeling

Łazar-Poniatowska, Małgorzata; Kamińska, Joanna; Konopa, Krzysztof; Dziadziuszko, Rafał; Jassem, Jacek

doi:10.5603/rpor.a2022.0110

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…A, Central P-values of subgroup comparisons a Dosimetric ------------------------------------------------------------------------------------------------------parameter 3D-CRT IMRT h-IMRT VMAT 1 vs. ----------------------------------------------------------------------------------------------------- radiation-induced esophagitis will have a negative effect on the patients' long-term survival (40). In order to predict the probability of radiation esophagitis, the three parameters of esophageal V 50 , D max and D mean were selected as the prediction reference values in the present study.…”

Section: A Left P-values Of Subgroup Comparisons a Dosimetric -------...mentioning

confidence: 99%

Dosimetric comparison of four radiotherapy techniques for stage III non‑small cell lung cancer

Luo

Song

et al. 2023

Oncol Lett

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The present study was implemented to compare the dosimetric parameters of the target dose coverage and critical structures in the treatment planning of four radiotherapy techniques [namely, three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), hybrid IMRT (h-IMRT) and volumetric-modulated arc therapy (VMAT)] for stage III non-small cell lung cancer (NSCLC) qualified plans for medical physicists, therapists and physicians. A total of 40 patients confirmed to have stage IIIA or IIIB NSCLC were enrolled, and four plans were designed for each patient. The prescription dose to the planning target volume (PTV) was assigned as 60 Gy in 30 fractions. The conformity index (CI), heterogeneity index (HI) and parameters of organs at risk (OARs) were calculated. For the PTV, the CI for VMAT was found to be the highest of all the four techniques (P<0.05), whereas the HI for the h-IMRT technique was found to be the lowest (P<0.05). Concerning the OARs, for the percentage of lung volume receiving a dose >5 Gy (lung V 5 ), the highest value was obtained with VMAT (P<0.05), whereas for lung V 30 and heart V 30 , the VMAT and IMRT techniques were found to be better compared with 3D-CRT and h-IMRT (P<0.05). For esophagus V 50 , the maximal dose (D max ) and mean dose for the IMRT technique displayed the best results (P<0.05), and in the case of the spinal cord, the D max with VMAT showed a significant advantage over the other techniques (P<0.05). The treatment monitor units (MUs) in IMRT were found to be the largest (P<0.05), whereas the treatment time with VMAT was the shortest (P<0.05). For smaller PTVs, VMAT was the technique that provided the optimal dose distribution and sparing of the heart. Compared with 3D-CRT alone, adding 20% IMRT to the 3D-CRT base plan was shown to improve the plan quality, and IMRT and VMAT, as techniques, had better dose coverage and sparing of OARs. Furthermore, for patients in whom the lung V5 could be kept low enough, VMAT potentially offered a good alternative to the technique to IMRT, thereby offering additional possibilities for sparing of other OARs, and decreasing the MUs and treatment time.

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Section: A Left P-values Of Subgroup Comparisons a Dosimetric -------...mentioning

confidence: 99%

Dosimetric comparison of four radiotherapy techniques for stage III non‑small cell lung cancer

Luo

Song

et al. 2023

Oncol Lett

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Reduced frequency and severity of radiation esophagitis without marginal failure risk by contralateral esophagus sparing IMRT in stage III non-small cell lung cancer patients undergoing definitive concurrent chemoradiotherapy

Lim,

Yang,

Noh

et al. 2024

Radiotherapy and Oncology

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Contralateral esophageal sparing technique in definitive radiotherapy for non-small cell lung cancer: dosimetric parameters and normal tissue complication probability modeling

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.

Cited by 2 publications

References 23 publications

Dosimetric comparison of four radiotherapy techniques for stage III non‑small cell lung cancer

Dosimetric comparison of four radiotherapy techniques for stage III non‑small cell lung cancer

Reduced frequency and severity of radiation esophagitis without marginal failure risk by contralateral esophagus sparing IMRT in stage III non-small cell lung cancer patients undergoing definitive concurrent chemoradiotherapy

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