Contralateral Lung Injury Associated With Single-Lung Ischemia-Reperfusion Injury

Watanabe, Atsushi; Kawaharada, Nobuyoshi; Kusajima, Katsuyuki; Komatsu, S; Takahashi, Hiroki

doi:10.1016/s0003-4975(96)00810-7

Cited by 23 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Some of these could thus reach the contralateral lung and induce damage. As in similar prior studies, 22 this work found that the left pulmonary artery occlusion and reperfusion had an impact on the non-ischaemic right lung at 4 hpr. Therefore, prolonging the observation time of reperfusion would be beneficial to the study of PIRI to determine precisely when CT and perfusion abnormalities resolve.…”

Section: Discussionsupporting

confidence: 85%

“…This suggests that extra caution and preventative measures should be taken clinically in patients approaching 3 hpr. Watanabe et al 22 mentioned that because of the vasospasm and micro thrombi in the ischaemic lung, inflammatory mediators and factors in the blood could cause parenchymal damage in the lung contralateral to arterial occlusion/embolization. This was seen in every case in this study, both pathologically and by imaging appearance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lung ischaemia–reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

Lü

Xu²,

Zhang³

et al. 2014

BJR

View full text Add to dashboard Cite

both contributed equally to this article.Objective: To evaluate dual-energy CT (DECT) findings of pulmonary ischaemic-reperfusion injury (PIRI) and its pathophysiological correlation in the canine model. Methods: A PIRI model was established in 11 canines, utilizing closed pectoral balloon occlusion. Two control canines were also included. For the PIRI model, the left pulmonary artery was occluded with a balloon, which was deflated and removed after 2 h. DECT was performed before, during occlusion and at 2, 3 and 4 h thereafter and was utilized to construct pulmonary perfusion maps. Immediately after the CT scan at the fourth hour post reperfusion, the canines were sacrificed, and lung specimens were harvested for pathological analysis. CT findings, pulmonary artery pressure and blood gas results were then analysed. Results: Data at every time point were available for 10 animals (experimental group, n 5 8; control group, n 5 2).Quantitative measurements from DECT pulmonary perfusion maps found iodine attenuation values of the left lung to be the lowest at 2 h post embolization and the highest at 1 h post reperfusion. In the contralateral lung, perfusion values also peaked at 1 h post reperfusion. Continuous hypoxia and acid-based disorders were observed during PIRI, and comprehensive analysis showed physiological changes to be worst at 3 h post reperfusion. Conclusion: DECT pulmonary perfusion mapping demonstrated pulmonary perfusion of the bilateral lungs to be the greatest at 1 h post reperfusion. These CT findings corresponded with pathophysiological changes. Advances in knowledge: DECT pulmonary perfusion mapping can be used to evaluate lung ischaemiareperfusion injury.Ischaemia-reperfusion injury (IRI) occurs under a variety of clinical conditions, including lung and/or cardiac transplantation, cardiopulmonary bypass, pulmonary resection, re-expansion pulmonary oedema, shock, cardiopulmonary resuscitation and pulmonary embolism.1-3 Pulmonary embolism is a common cause of pulmonary IRI (PIRI), and the incidence of pulmonary embolism is increasing 4,5 with a mortality rate of up to 30%. 6 With timely identification and treatment of pulmonary embolism, mortality rates can be reduced to ,10%.7 However, reperfusion after treatment for lung ischaemia can also cause serious complications, such as haemorrhage and pulmonary oedema.8 Therefore, it is important to understand both the pathophysiological and imaging appearances of pulmonary IRI. Lung transplantation is also a common cause for PIRI following pulmonary arterial occlusion. Currently, the incidence of PIRI following transplantation is estimated at up to 25%. Post transplantation, PIRI can lead to insufficiency of the primary lung graft, delayed graft function, acute or chronic rejection (e.g. pulmonary oedema and acute respiratory failure), and increased early post-operative mortality and graft failure. 9,10 CT is currently the predominant modality for the imaging assessment of thoracic disorders, including PIRI. Dual-energy CT (DECT) allows simultaneous ac...

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Lung ischaemia–reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

Lü

Xu²,

Zhang³

et al. 2014

BJR

View full text Add to dashboard Cite

show abstract

“…3 Another experimental study demonstrated the role of chemical sympathectomy in preventing the decrease in contralateral ovarian blood flow, which may be due to a neurovascular reflex mechanism, during unilateral ovarian torsion in rabbits. 12 Watanabe et al 5 studied the effect of single lung ischemia-reperfusion on the function of the contralateral lung and reported that some free radicals, proteases, and mediators were released into the bloodstream during the reperfusion phase, which injured the contralateral lung. This injury was almost the same as in the ischemic lung.…”

Section: Discussionmentioning

confidence: 99%

“…b There were widespread macrophages associated with membrane-bound vacuoles and an electron-dense amorphous substance (black arrow). (ϫ6 000) [1][2][3][4][5][6][7][8] We conducted the present study to determine whether ischemic unilateral lung injury can result in contralateral organ damage. Our findings showed that early degenerative ultrastructural changes occurred in the contralateral lung tissue after unilateral lung ischemia, the degree of which was closely related to the duration of the ischemia.…”

Section: Contralateral Lungs In the 8-h Ischemia Groupmentioning

confidence: 99%

“…All the studies we found on this subject focused on postpneumonectomy syndrome or ischemia/reperfusion injury of the lungs. [5][6][7] Therefore, we investigated the acute ultrastructural changes in the contralateral lung tissue after unilateral ischemia. During some lung operations, if the procedure is unnecessarily prolonged the contralateral lung may be affected.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrastructural Changes in the Contralateral Lung Tissue Following Unilateral Lung Ischemia: An Experimental Study in Rabbits

et al. 2004

View full text Add to dashboard Cite

show abstract

Detection of lung transplant rejection in a rat model using hyperpolarized [1‐¹³C] pyruvate‐based metabolic imaging

et al. 2019

View full text Add to dashboard Cite

The current standard for noninvasive imaging of acute rejection consists of X-ray/CT, which derive their contrast from changes in ventilation, inflammation and edema, as well as remodeling during rejection. We propose the use of hyperpolarized [1-13 C] pyruvate MRI-which provides real-time metabolic assessment of tissue-as an early biomarker for tissue rejection.In this preliminary study, we used μCT-derived parameters and HP 13 C MR-derived biomarkers to predict rejection in an orthotopic left lung transplant model in both allogeneic and syngeneic rats.On day 3, the normalized lung density-a parameter that accounts for both lung volume (mL) and density (HU)-was −0.335 (CI: -0.598, −0.073) and − 0.473 (CI: -0.726, −0.220) for the allograft and isograft, respectively (not significant, 0.40). The lactate-to-pyruvate ratios-derived from the HP 13 C MRI-for the allograft and isograft were 0.200 (CI: 0.161, 0.240) and 0.114 (CI: 0.074, 0.153), respectively (significant, 0.020). Both techniques showed tissue rejection on day 7. A separate sub-study revealed CD8+ cells as the primary source of the lactate-to-pyruvate signal.Our study suggests that hyperpolarized (HP) [1-13 C] pyruvate MRI is a promising early biomarker for tissue rejection that provides metabolic assessment in real time based on changes in cellularity and metabolism of lung tissue and the infiltrating inflammatory cells, and may be able to predict tissue rejection earlier than X-ray/CT.

show abstract

Contralateral Lung Injury Associated With Single-Lung Ischemia-Reperfusion Injury

Cited by 23 publications

References 13 publications

Lung ischaemia–reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

Lung ischaemia–reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

Ultrastructural Changes in the Contralateral Lung Tissue Following Unilateral Lung Ischemia: An Experimental Study in Rabbits

Detection of lung transplant rejection in a rat model using hyperpolarized [1‐¹³C] pyruvate‐based metabolic imaging

Contact Info

Product

Resources

About

Contralateral Lung Injury Associated With Single-Lung Ischemia-Reperfusion Injury

Cited by 23 publications

References 13 publications

Lung ischaemia–reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

Lung ischaemia–reperfusion injury in a canine model: dual-energy CT findings with pathophysiological correlation

Ultrastructural Changes in the Contralateral Lung Tissue Following Unilateral Lung Ischemia: An Experimental Study in Rabbits

Detection of lung transplant rejection in a rat model using hyperpolarized [1‐13C] pyruvate‐based metabolic imaging

Contact Info

Product

Resources

About

Detection of lung transplant rejection in a rat model using hyperpolarized [1‐¹³C] pyruvate‐based metabolic imaging