Contrast-Enhanced Mammography (CEM) Capability to Distinguish Molecular Breast Cancer Subtypes

Łuczyńska, Elżbieta; Piegza, Tomasz; Szpor, Joanna; Heinze, Sylwia; Popiela, Tadeusz; Kargol, Jaromir; Rudnicki, Wojciech

doi:10.3390/biomedicines10102384

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…In the work of Rudnicki et al [ 15 ] on a group of Polish patients from a region of the country similar to that of our study, the sensitivity of CEM in the case of extremely dense breasts was as high as 100%. In the work of Łuczyńska et al [ 16 ], the sensitivity of CEM in the patients with extremely dense breasts was 92.7%, higher than in the case of mammography and ABUS. In the study by Qin et al [ 17 ], sensitivity was estimated at only 82.4%.…”

Section: Discussionmentioning

confidence: 97%

Comparison of the effectiveness of contrast-enhanced mammography in detecting malignant lesions in patients with extremely dense breasts compared to the all-densities population

Grażyńska,

Niewiadomska,

Owczarek

et al. 2024

Pol J Radiol

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PurposeTo assess the effectiveness of contrast-enhanced mammography (CEM) recombinant images in detecting malignant lesions in patients with extremely dense breasts compared to the all-densities population.Material and methods792 patients with 808 breast lesions, in whom the final decision on core-needle biopsy was made based on CEM, and who received the result of histopathological examination, were qualified for a single-centre, retrospective study. Patient electronic records and imaging examinations were reviewed to establish demographics, clinical and imaging findings, and histopathology results. The CEM images were reassessed and assigned to the appropriate American College of Radiology (ACR) density categories.ResultsExtremely dense breasts were present in 86 (10.9%) patients. Histopathological examination confirmed the presence of malignant lesions in 52.6% of cases in the entire group of patients and 43% in the group of extremely dense breasts. CEM incorrectly classified the lesion as false negative in 16/425 (3.8%) cases for the whole group, and in 1/37 (2.7%) cases for extremely dense breasts. The sensitivity of CEM for the group of all patients was 96.2%, specificity – 60%, positive predictive values (PPV) – 72.8%, and negative predictive values (NPV) – 93.5%. In the group of patients with extremely dense breasts, the sensitivity of the method was 97.3%, specificity – 59.2%, PPV – 64.3%, and NPV – 96.7%.ConclusionsCEM is characterised by high sensitivity and NPV in detecting malignant lesions regardless of the type of breast density. In patients with extremely dense breasts, CEM could serve as a complementary or additional examination in the absence or low availability of MRI.

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Section: Discussionmentioning

confidence: 97%

Comparison of the effectiveness of contrast-enhanced mammography in detecting malignant lesions in patients with extremely dense breasts compared to the all-densities population

Grażyńska,

Niewiadomska,

Owczarek

et al. 2024

Pol J Radiol

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“…A ressonância magnética das mamas é um exame muito utilizado no diagnóstico do câncer de mama, tanto na identificação no tipo de câncer, quanto para avaliar sua recorrência. Luczynska et al (2022) e inconsistência de resultados de exames inconclusivos de mamografia e ultrassonografia. Bitencourt et al (2021) As principais indicações da ressonância magnética das mamas são tanto para estadiamento pré-operatório em pacientes com câncer de mama, quanto para se obter informações adicionais para planejamento terapêutico, já que o exame apresenta alta sensibilidade e precisão, tornando possível um melhor diagnóstico e leitura a respeito da extensão tumoral e detecção de tumores.…”

Section: Principais Indicações Para Rm Da Mamaunclassified

O papel da Ressonância Magnética no diagnóstico e rastreio do câncer de mama no Brasil

Silva¹,

Chaves²,

Guimarães³

et al. 2023

RSD

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O presente artigo busca elucidar para a população e para os profissionais da saúde, os riscos, benefícios, desvantagens e principais usos da ressonância magnética no rastreio e manejo do câncer de mama no Brasil. Dessa forma, buscou-se em artigos e trabalhos da área, em bases do Scielo as informações mais atuais e relevantes nesse cenário, dentro dos últimos 5 anos, explicando desde a realidade atual do câncer de mama no país, até os princípios do funcionamento desse equipamento, que representa uma grande evolução nos exames de imagem. Como resultado, foi obtida uma série de informações que garante a indicação da ressonância magnética no câncer de mama como uma boa ferramenta para suporte das decisões clínicas e acompanhamento dos pacientes. Dessa forma, notou-se que mesmo com o grande apoio tecnológico fornecido, ainda é imprescindível a boa conduta e formação médica para a aplicação do conhecimento de forma correta, garantindo a saúde e integridade dos pacientes. Sendo assim, muito ainda se espera da evolução do método e seu aperfeiçoamento para o futuro, para que possa oferecer um diagnóstico ainda mais precoce e fidedigno, garantindo o tratamento precoce e melhora do prognóstico dos pacientes acometidos.

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“…CEM utilizes contrast media and a dual energy image acquisition technique: the standard two mammographic views of each breast are obtained two minutes after the injection of intravenous (IV) iodinated contrast material, using X-ray exposures at two different average beam energies, above and below the k-edge of iodine (~ 33 keV). This results in a low energy (LE) image (diagnostically equivalent to a standard mammogram) and a high energy (HE) image; the latter is not used for diagnosis but is used in a weighted subtraction process to produce a recombined image in which background features of normal breast tissue are suppressed and areas of contrast uptake highlighted, facilitating assessment of neoangiogenesis [20,24]. A CEM study is quick and easy to perform, and unlike MRI does not require specialized training to report.…”

Section: Introductionmentioning

confidence: 99%

The verification of the utility of a commercially available phantom combination for quality control in contrast-enhanced mammography

Kim,

Kessell,

Taylor

et al. 2024

Preprint

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Contrast-enhanced mammography (CEM) is being increasingly implemented clinically, providing much improved contrast between tumour and background structures, particularly in dense breasts. Although CEM is similar to conventional mammography it differs via an additional exposure with high energy X-rays (≥ 40 kVp) and subsequent image subtraction. Because of its special operational aspects, the CEM aspect of a CEM unit needs to be uniquely characterised and evaluated. This study aims to verify the utility of a commercially available phantom set (BR3D model 020 and CESM model 022 phantoms (CIRS, Norfolk, Virginia, USA)) in performing key CEM performance tests (linearity of system response with iodine concentration and background subtraction) on two models of CEM units in a clinical setting. The tests were successfully performed, yielding results similar to previously published studies. Further, similarities and differences in the two systems from different vendors were highlighted, knowledge of which may potentially facilitate optimisation of the systems.

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Contrast-Enhanced Mammography (CEM) Capability to Distinguish Molecular Breast Cancer Subtypes

Cited by 12 publications

References 32 publications

Comparison of the effectiveness of contrast-enhanced mammography in detecting malignant lesions in patients with extremely dense breasts compared to the all-densities population

Comparison of the effectiveness of contrast-enhanced mammography in detecting malignant lesions in patients with extremely dense breasts compared to the all-densities population

O papel da Ressonância Magnética no diagnóstico e rastreio do câncer de mama no Brasil

The verification of the utility of a commercially available phantom combination for quality control in contrast-enhanced mammography

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