Contrasts in Oxidative Potential and Other Particulate Matter Characteristics Collected Near Major Streets and Background Locations

Boogaard, Hanna; Janssen, Nicole; Fischer, Paul; Kos, G.P.A.; Weijers, E.P.; Cassee, Flemming R.; Zee, Saskia C. van der; Hartog, Jeroen J. de; Brunekreef, Bert; Hoek, Gerard

doi:10.1289/ehp.1103667

Cited by 100 publications

(77 citation statements)

References 29 publications

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“…These results can be explained by the specificity of the ESR assay towards hydroxyl radical generation and in the case of Ba (not redox-active) linked to its co emission with the former redox active compounds. These results agree with the study of Boogaard et al (2012) where the OP ESRv of PM collected near major urban road were highly correlated with Cr, Cu and Ba. However, OP ESRv is also 15 associated to organic compounds (OC, PAH) in other studies .…”

Section: Univariate Data Analysessupporting

confidence: 92%

“…DTT is known to react with organic compounds but also with transition metals (Charrier and Anastasio, 2012;Lin and Yu, 2011). The ESR assay employs the spin trap 5,5-Dimethyl-1-pyrroline N-oxide (DMPO) and is specific for reactive radical species, which for example result from partial reduction of dioxygen catalyzed by transition metal (Boogaard et al, 2012;Shi et al, 2003). The AA assays would be more 30 specific to the oxidative potential of transition metals (Godri et al, 2011;, but ascorbic acid is known to react with organics such as quinones (Shang et al, 2012;Visentin et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM<sub>10</sub> samples from the city of Chamonix (France)

Calas¹,

Uzu²,

Kelly³

et al. 2017

Preprint

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Abstract. Many studies have demonstrated associations between exposure to ambient particulate matter (PM) and adverse health outcomes in humans that can be explained by PM capacity to induce oxidative stress in vivo. Thus, assays have been developed to quantify the oxidative potential (OP) of PM as a more refined exposure metric than PM mass alone. Only a 15 small number of studies have compared different acellular OP measurements for a given set of ambient PM samples. Yet, fewer studies have compared different assays over a year long period and with detailed chemical characterization of ambient PM. In this study, we report on seasonal variations of the dithiothreitol (DTT), ascorbic acid (AA), electron spin resonance (ESR) and the respiratory tract lining fluid (RTLF, composed of the reduced glutathione (GSH) and ascorbic acid (ASC)) assays over a one year period in which 100 samples were analysed. A detailed PM 10 characterization allowed univariate and 20 multivariate regression analyses in order to obtain further insight into groups of chemical species that drive OP measurements. Our results show that most of the OP assays were strongly inter-correlated over the sampling year but also these correlations differed when considering specific sampling periods (cold vs warm). All acellular assays are correlated with a significant number of chemical species when considering univariate correlations, especially for the DTT assay.Evidence is also presented of a seasonal contrast over the sampling period with significantly higher OP values during winter 25 for the DTT, AA, GSH and ASC assays, which were assigned to biomass burning species by the multiple linear regression models. The ESR assay clearly differs from the other tests as it did not show seasonal dynamics and presented weaker correlations with other assays and chemical species.Atmos. Chem. Phys. Discuss., https://doi

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Section: Univariate Data Analysessupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM<sub>10</sub> samples from the city of Chamonix (France)

Calas¹,

Uzu²,

Kelly³

et al. 2017

Preprint

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“…Soto et al (2008) reported the cytotoxicity of BC in commercial nanoparticle materials. Boogaard et al (2012) observed an association between PM oxidative potential and soot carbon in ambient aerosol collected in traffic areas. Harder et al (2005) reported the effect of BC on heart-rate increase but no inflammatory effects, while Cho et al (2005) observed a correlation between ambient soot carbon and PM oxidative potential.…”

Section: Particulate Matter and Healthmentioning

confidence: 91%

Particulate matter, air quality and climate: lessons learned and future needs

et al. 2015

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Abstract. The literature on atmospheric particulate matter (PM), or atmospheric aerosol, has increased enormously over the last 2 decades and amounts now to some 1500-2000 papers per year in the refereed literature. This is in part due to the enormous advances in measurement technologies, which have allowed for an increasingly accurate understanding of the chemical composition and of the physical properties of atmospheric particles and of their processes in the atmosphere. The growing scientific interest in atmospheric aerosol particles is due to their high importance for environmental policy. In fact, particulate matter constitutes one of the most challenging problems both for air quality and for climate change policies. In this context, this paper reviews the most recent results within the atmospheric aerosol sciences and the policy needs, which have driven much of the increase in monitoring and mechanistic research over the last 2 decades.The synthesis reveals many new processes and developments in the science underpinning climate-aerosol interactions and effects of PM on human health and the environment. However, while airborne particulate matter is responsible for globally important influences on premature human mortality, we still do not know the relative importance of the different chemical components of PM for these effects. Likewise, the magnitude of the overall effects of PM on climate remains highly uncertain. Despite the uncertainty there are many things that could be done to mitigate local and global problems of atmospheric PM. Recent analyses have shown that reducing black carbon (BC) emissions, using known control measures, would reduce global warming and delay the time when anthropogenic effects on global temperature would exceed 2 • C. Likewise, cost-effective control measures on ammonia, an important agricultural precursor gas for secondary inorganic aerosols (SIA), would reduce regional eutrophication and PM concentrations in large areas of Europe, China and the USA. Thus, there is much that could be done to reduce the effects of atmospheric PM on the climate and the health of the environment and the human population.A prioritized list of actions to mitigate the full range of effects of PM is currently undeliverable due to shortcomings in the knowledge of aerosol science; among the shortcomings, the roles of PM in global climate and the relative roles of Published by Copernicus Publications on behalf of the European Geosciences Union. 8218S. Fuzzi et al.: Particulate matter, air quality and climate different PM precursor sources and their response to climate and land use change over the remaining decades of this century are prominent. In any case, the evidence from this paper strongly advocates for an integrated approach to air quality and climate policies.

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“…Its possible importance for health is currently being discussed (Shiraiwa, Selzle & Pöschl, 2012). Initial studies on spatial and temporal variations of particle reactivity parameters have been conducted (Boogaard et al, 2012a;Künzli et al, 2006). Still missing is the link between particle reactivity and other particle characteristics, the actual mechanisms triggered, and the ageing and/or changes of particle reactivity during atmospheric transport due to chemical reactions.…”

Section: Changing Reactivity Over Time or With Increasing Distance Frmentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Contrasts in Oxidative Potential and Other Particulate Matter Characteristics Collected Near Major Streets and Background Locations

Cited by 100 publications

References 29 publications

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM<sub>10</sub> samples from the city of Chamonix (France)

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM<sub>10</sub> samples from the city of Chamonix (France)

Particulate matter, air quality and climate: lessons learned and future needs

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

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Contrasts in Oxidative Potential and Other Particulate Matter Characteristics Collected Near Major Streets and Background Locations

Cited by 100 publications

References 29 publications

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM&lt;sub&gt;10&lt;/sub&gt; samples from the city of Chamonix (France)

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM&lt;sub&gt;10&lt;/sub&gt; samples from the city of Chamonix (France)

Particulate matter, air quality and climate: lessons learned and future needs

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

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Product

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About

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM<sub>10</sub> samples from the city of Chamonix (France)

Comparison between five acellular oxidative potential measurement assays performed with detailed chemistry on PM<sub>10</sub> samples from the city of Chamonix (France)