Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis

Liu, Y.Z.; Jackson, Anne; Cosgrove, Stephen D.

doi:10.1016/j.joca.2009.04.022

Cited by 58 publications

(35 citation statements)

References 50 publications

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“…This hypothesis is further supported by Fuerst and colleagues' findings that chondrocytes isolated from mineralized OA cartilage could undergo hypertrophic differentiation and might ultimately produce BCPs. However, as recently described by Liu et al (10), and as we have also observed, isolation of chondrocytes from a crystalcontaining articular cartilage leads to crystal release in the culture medium, so that the distinction between crystals released from the matrix and newly produced crystals is difficult to ascertain.…”

Section: To the Editormentioning

confidence: 48%

Osteoarthritis, a basic calcium phosphate crystal–associated arthropathy? Comment on the article by Fuerst et al

Nguyen¹,

Ea²,

Bazin³

et al. 2010

Arthritis & Rheumatism

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A new method of introducing dithioester groups into the polymer chain of poly(cyclohexene oxide) is reported. It includes the use of diaryliodonium salt and an aromatic dithioacid as a redox couple to initiate the cationic polymerization of cyclohexene oxide. It was found that the dithioacid by itself cannot start the polymerization of cationic polymerizable monomers; however, in combination with a diaryliodonium salt, an exothermic reaction was produced, yielding a thiocarbonylthio‐functionalized polyether. Thermal profiles of the redox polymerizations were determined by means of optical pyrometry. A preliminary study showed that when the poly(cyclohexene oxide) functionalized with dithioester groups was introduced into the radical polymerization of styrene, the polystyryl growing radicals reacted with the dithioester‐functionalized polyether to form a block polymer. The amount of polyether actually incorporated into the block copolymer was calculated to be 70% of the initial amount of poly(cyclohexene oxide)/dithiobenzoic acid charged into the reactor. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008

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Section: To the Editormentioning

confidence: 48%

Osteoarthritis, a basic calcium phosphate crystal–associated arthropathy? Comment on the article by Fuerst et al

Nguyen¹,

Ea²,

Bazin³

et al. 2010

Arthritis & Rheumatism

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“…Fist, calcium deposition has been shown to play a significant role in OA pathology, including the articular cartilage [36][37][38]. Calcium deposition has been shown to lesson actual mechanical efficacy of the articular cartilage and associated menisci [38].…”

Section: Discussionmentioning

confidence: 99%

Identification of the Tidemark Line of Calcification in Osteoarthritic Cartilage Using a Stain for Alkaline Phosphatase

Black¹,

Crepeau²,

Sheffield³

et al. 2017

J Arthritis

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Inflammatory response and calcification are strongly implicated in osteoarthritis (OA) progression. Key inflammatory biomarkers present throughout the process of OA have been established but an association with calcification has not been clarified. A faint line, tidemark, exists between the subchondral bone and the articular surface in knee joints that is presumed to be the line of demarcation between calcified and uncalcified cartilage. This study shows that the tidemark is where calcification is actively occurring. Mouse knees (n=8) were stained for both Alkaline Phosphatase (ALP) and Safranin-O/Fast Green. ALP, active during tissue calcification, was used to identify the true location of calcification. Images from both stains were overlaid for comparison of complementary tissues. The cartilage area above the tidemark was then compared to the area above the ALP line of calcification. Because the two areas proved to be nearly statistically identical, the conclusion is that the tidemark observed in the Safranin-O/Fast Green stain is indeed the line of calcification for articular cartilage. The role of calcification in OA was further examined by comparing NPP1, calcification marker, with HtrA1. We demonstrate a reciprocal correlation between HtrA1 and NPP1, suggesting a link between pathological calcification and inflammation in joints experiencing OA.

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“…Basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPPD) crystals are commonly found in osteoarthritic joints. These crystals have been found in the synovial fluid of 60% of patients with knee OA and over 90% of a small group of patients with grade-4 OA [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…The rationale using colchicine as disease/ structure-modifying drug to manage OA resides in the fact that calcium-containing crystals are frequently seen in OA (3,4), and colchicine has been shown to be beneficial in preventing calcium crystal-induced inflammation (pseudogout). When used to treat gouty arthritis, colchicine is believed to work by inhibiting microtubule dependent cell infiltration and IL-1β production.…”

Section: Introductionmentioning

confidence: 99%

Effect of Colchicine on Total Antioxidant Capacity, Antioxidant Enzymes and Oxidative Stress Markers in Patients with Knee Osteoarthritis

Erden¹,

Ediz²,

Hiz³

et al. 2012

IJCM

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Background/Aim: We aimed to investigate the effects of colchicine on clinical recovery, as well as oxidative stress markers and total antioxidant capacity (TAC) in whole blood of patients with knee osteoarthritis (OA). Materials and Methods: Sixty patients with grade 2 -3 knee OA according to ACR knee OA criteria whom examination of the knee joint synovial fluid by polarized light microscopy demonstrated CPDD crystals existence were included in the study. Fifty healthy subjects were included as a control group. Patients were divided randomly into two groups. The first group (paracetamol group) was given only paracetamol 3 gr daily p.o and the second group (colchicine and paracetamol group) was given colchicine 1.5 gr and paracetamol 3 gr daily p.o for six months. For outcome measures WOMAC and VAS were used. Superoxide dismutase (SOD), Catalase (CAT) ezyme activities and Glutathione (GSH) and Malondialdehyde (MDA) levels and TAC all were measured. Results: WOMAC scores were improved in both patient groups compared with pre-treatment evaluation (p < 0.025). WOMAC morning stiffness scores were significantly more improved in colchicine group compared with paracetamol group (p > 0.05). TAC was signifcantly increased only in colchicine/paracetamol group. Oxidant parameter MDA levels were significantly decreased in both paracetamol group and colchicine/paracetamol group. CAT, SOD enzyme activities and GSH levels did not change before and after treatment protocols in both patient groups. Conclusion: Both paracetamol 3000 mg/day and 3000 mg paracetamol plus 1.5 gr/day colchicine is effective in the treatment of patients with knee osteoarthritis. But the addition of colchicine to paracetamol produced significantly greater symptomatic benefit than paracetamol alone. Our study also showed that colchicine lowers whole blood MDA which is a lipid peroxidation compound and elevates TAC levels in patients with knee OA. This may show probable disease modifying effect of colchicine in knee OA which require further long period laboratory and radiologic investigations.

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Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis

Cited by 58 publications

References 50 publications

Osteoarthritis, a basic calcium phosphate crystal–associated arthropathy? Comment on the article by Fuerst et al

Osteoarthritis, a basic calcium phosphate crystal–associated arthropathy? Comment on the article by Fuerst et al

Identification of the Tidemark Line of Calcification in Osteoarthritic Cartilage Using a Stain for Alkaline Phosphatase

Effect of Colchicine on Total Antioxidant Capacity, Antioxidant Enzymes and Oxidative Stress Markers in Patients with Knee Osteoarthritis

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