Contribution of high resolution peripheral quantitative CT to the management of bone and joint diseases

Lespessailles, Éric; Ibrahim-Nasser, Nada; Toumi, Hechmi; Chapurlat, Roland

doi:10.1016/j.jbspin.2017.04.012

Cited by 14 publications

(14 citation statements)

References 57 publications

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“…In most of the studies providing a link between the cardiovascular system and loss of bone and osteoporosis, the assessment of BMD was done by conventional dual energy X-ray absorptiometry devices that permitted areal BMD but not volumetric BMD measurements [ 17 , 20 ]. In addition, computed tomography and HRpQCT devices now allow separate analysis of the trabecular and cortical compartment [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…We have reported that digital ulcers were independent risk factors for bone damage, using for the first time a High Resolution peripheral Quantitative Computed Tomography device (HRpQCT) to investigate the bone status [ 15 ]. HRpQCT is a new and most promising 3D imaging technique which has been primarily developed to explore the quality of bone [ 16 ]. However thanks to its capacity to image fine details (75 to 100 μm) emerging data on Rheumatoid Arthritis and connective tissue disease also exists [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…HRpQCT is a new and most promising 3D imaging technique which has been primarily developed to explore the quality of bone [ 16 ]. However thanks to its capacity to image fine details (75 to 100 μm) emerging data on Rheumatoid Arthritis and connective tissue disease also exists [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study

et al. 2018

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ObjectiveTo investigate the link between bone alteration and micro- and macro-vascular disease in patients with systemic sclerosis (SSc).Results33 SSc patients were included. In univariate analysis, low values of cortical vBMD were significantly associated with a low DBI at the 2nd finger (p = 0.004) and at the 4th (p = 0.002) and with severe capillaroscopic score (p = 0.008). In multivariate analyses, low cortical vBMD was associated with a low DBI at the 4th finger, age and severe capillaroscopic score (adjusted R2 = 0.58; p = < 0.001). Low cortical thickness was associated with a low DBI at the 4th finger, severe capillaroscopic score and age (adjusted R2 = 0.49, p = < 0.001).ConclusionOur study findings showed an association between micro- and macro-vessel damage and altered microarchitectural indices at the radius in SSc.MethodsWe performed a pilot study in female patients with SSc. Microvascular disease was assessed by the capillaroscopic score of Cutolo. Macrovascular involvement was measured by digito-brachial pressure index (DBI) on laser-Doppler at the 2nd and 4th finger. Volumetric bone mineral density (vBMD) and bone microarchitecture involvement were analysed by High-Resolution peripheral Quantitative Computed Tomography (HRpQCT) at the distal radius.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study

et al. 2018

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“…Computed tomography is well-suited to the study of bone and provides high-resolution images that can be automatically- or semi-automatically segmented to render volumetric representations (Dufresne, 1998 ). Peripheral quantitative CT can be used to image cortical and trabecular bone microstructure (Lespessailles et al, 2017 ), which are important structural features to include in analysis of bone remodeling (Hambli, 2011 ). However, CT exposes tissues to ionizing radiation and may not be suitable for certain clinical or developing populations.…”

Section: Mechanobiology and The Optimal Mechanical Environment For Mumentioning

confidence: 99%

Bioinspired Technologies to Connect Musculoskeletal Mechanobiology to the Person for Training and Rehabilitation

Pizzolato

Lloyd

Barrett

et al. 2017

Front. Comput. Neurosci.

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Musculoskeletal tissues respond to optimal mechanical signals (e.g., strains) through anabolic adaptations, while mechanical signals above and below optimal levels cause tissue catabolism. If an individual's physical behavior could be altered to generate optimal mechanical signaling to musculoskeletal tissues, then targeted strengthening and/or repair would be possible. We propose new bioinspired technologies to provide real-time biofeedback of relevant mechanical signals to guide training and rehabilitation. In this review we provide a description of how wearable devices may be used in conjunction with computational rigid-body and continuum models of musculoskeletal tissues to produce real-time estimates of localized tissue stresses and strains. It is proposed that these bioinspired technologies will facilitate a new approach to physical training that promotes tissue strengthening and/or repair through optimal tissue loading.

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“…HRpQCT has been reported to be predictive of incident fracture, independently of areal BMD. (6)(7)(8) However, this method is not yet accessible in clinical practice; hence, alternate measures of bone fracture risk are needed.…”

Section: Introductionmentioning

confidence: 99%

Lack of Association Between Select Circulating miRNAs and Bone Mass, Turnover, and Fractures: Data From the OFELY Cohort

Feurer

Kan

Croset

et al. 2019

Journal of Bone and Mineral Research

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Postmenopausal osteoporosis is characterized by the occurrence of fragility fracture with an increase in morbidity and mortality. Recently, microRNAs (miRNAs) have raised interest as regulators of translational repression, mediating a number of key processes, including bone tissue in both physiological and diseased states. The aim of this study was to examine the serum levels of 32 preselected miRNAs with reported function in bone and their association with osteoporotic fracture. We performed cross-sectional and longitudinal analyses from the OFELY Cohort. Serum levels of the miRNAs were quantified by qRT-PCR in 682 women: 99 premenopausal and 583 postmenopausal women, with 1 and 122 women with prevalent fragility fractures in each group, respectively. We have collected clinical variables (such as age, prevalent, and incident fractures), bone turnover markers (BTMs), BMD by dual X-ray absorptiometry, and bone microarchitecture with HRpQCT. We observed a number of miRNAs to be associated with fragility fractures (prevalent or incident), BTMs, BMD, and microarchitecture. This effect, however, was negated after age adjustment. This may be because age was also strongly associated with the serum levels of the 32 miRNAs (correlation coefficient up to 0.49), confirming previous findings. In conclusion, in a well-characterized prospective cohort with a sizeable sample size, we found no evidence that these 32 preselected miRNAs were not associated with BTMs, BMD, microarchitecture, and or fragility fractures. Ã CTX, mg/L (min-max) 0.466 (0.057-1.470) 0.374 (0.107-1.030) 0.481 (0.057-1.470) Ã Osteocalcin, ng/mL (min-max) Ã Ã p value considered as significant if <0.05. Tt.vBMD ¼ total volumetric bone mineral density; Ct.vBMD ¼ cortical volumetric bone mineral density; Tb.vBMD ¼ trabecular volumetric bone mineral density; BAP ¼ bone alkaline phosphatase. Journal of Bone and Mineral Research LACK OF ASSOCIATION BETWEEN miRNAs AND BONE: DATA FROM THE OFELY COHORT 5 FEURER ET AL. Ã Radius Tt.vBMD, mg/cm 3 (min-max) 245.6 (122.9-482.1) 278.1 (101.9-515.8) Ã Radius Ct.vBMD, mg/cm 3 (min-max) 771.9 (556.9-956.4) 803.0 (572.6-1004.8) Ã Radius Tb.vBMD, mg/cm 3 (min-max) 123.2 (50.3-264.0) 141.8 (17.5-262.8) Ã Tibia Tt.vBMD, mg/cm 3 (min-max) 228.3 (124.2-371.2) 252.8 (109.0-417.4) Ã Tibia Ct.vBMD, mg/cm 3 (min-max) 702.6 (437.7-912.7) 744.6 (376.7-976.6) Ã Tibia Tb.vBMD, mg/cm 3 (min-max) 133.6 (52.0-212.6) 149.3 (31.9-254.7) Ã CTX, mg/L (min-max) 0.463 (0.057-1.16) 0.484 (0.062-1.470) NS Osteocalcin, ng/mL (min-max) 28.6 (4.2-90.2) 27.7 (6.5-86.2) NS P1NP, ng/mL (min-max) 49.0 (8.1-138.6) 21.5 (10.0-139.7) NS BAP, UI/L (min-max) 39.3 (15.2-69.4) 38.8 (10.1-88.6) NS Ã p-value considered as significant if <0.05. Tt.vBMD ¼ total volumetric bone mineral density; Ct.vBMD ¼ cortical volumetric bone mineral density; Tb.vBMD ¼ trabecular volumetric bone mineral density; BAP ¼ bone alkaline phosphatase. 8 FEURER ET AL.

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Contribution of high resolution peripheral quantitative CT to the management of bone and joint diseases

Cited by 14 publications

References 57 publications

Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study

Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study

Bioinspired Technologies to Connect Musculoskeletal Mechanobiology to the Person for Training and Rehabilitation

Lack of Association Between Select Circulating miRNAs and Bone Mass, Turnover, and Fractures: Data From the OFELY Cohort

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