Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobacter pylori related diseases

Yoshitake, Saeko; Okada, Mitsuo; Kimura, Akinori; Sasazuki, Takehiko

doi:10.1097/00042737-199908000-00011

Cited by 24 publications

(19 citation statements)

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“…1b, Table 2), Bonferroni's correction for multiple inferences is not strictly required for the chi‐squared analysis between HLA‐DQB1*0401 and gastric cancer because this association was particularly sought in the current study. Concerning DQB1*0401, a positive association in duodenal ulcers was reported in Japan, 26 but gastric cancer patients were not investigated in that study. The finding that the frequency of HLA class II alleles differs markedly between races should be considered 23 .…”

Section: Discussionmentioning

confidence: 99%

HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Watanabe

Aoyama

Sakai

et al. 2006

J of Gastro and Hepatol

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Background and Aims: It has been suggested that the incidence of digestive diseases associated with Helicobacter pylori is influenced by the strain diversity of H. pylori, factors involving the host or environment, and the duration of infection. The authors have previously reported that human leukocyte antigen (HLA)-DQB1*0401 plays an important role in the development of atrophic gastritis in H. pylori infected patients. The aim of the present study was to investigate the relationship between HLA-DQB1 genotype and cancer development. Methods: HLA-DQB1 genotyping was performed by the PCR-RFLP method on 122 H. pyloriinfected non-ulcer dyspepsia (NUD) patients, 53 gastric cancer patients and 28 uninfected controls. To reliably estimate the grade of atrophic gastritis, histological evaluation was performed. Results: The allele frequency of DQB1*0401 was significantly higher in intestinal type cancer patients compared with age-and sex-matched H. pylori-infected NUD patients. There was no significant difference in the mean atrophic scores of the biopsy samples from the lesser curvature of the mid-corpus between these groups. Conclusions: HLA-DQB1*0401 is a useful marker for determining susceptibility to intestinal type gastric cancer.

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Section: Discussionmentioning

confidence: 99%

HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Watanabe

Aoyama

Sakai

et al. 2006

J of Gastro and Hepatol

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“…For example, the development of pelvic inflammatory disease in infection due to Chlamydia trachomatis has been indirectly linked to HLA-DQA1*0401 and HLA-DQB1*0402, 29 and in infection by Helicobacter pylori, a microorganism that has also been related with vascular diseases, 14 the type of gastric pathology developed partially depends on the host's HLA class II alleles. 30 These associations may be expressions of disease susceptibility linked to HLA molecules; because HLA molecules function as antigen presenting structures, the particular set of HLA molecules expressed by an individual influences its functional T-cell repertoire, and for this reason HLA partly determines the individual response to antigens. Table 4 summarizes what our work adds to the previous knowledge on the topics of the relationship of EH with the HLA system and with C. pneumoniae infection.…”

Section: Discussionmentioning

confidence: 99%

Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)

Zabay¹,

Marco

Soler³

et al. 2005

J Hum Hypertens

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Separate studies investigating the relationship of essential hypertension (EH) with the HLA system and with Chlamydia pneumoniae (C. pneumoniae) infection have given conflicting results. Our aim was to clarify these relationships and determine whether the HLA system and C. pneumoniae infection interact with respect to the risk for EH. An association study (110 essential hypertensives and 107 controls) was conducted in a highly homogeneous population in the Balearic Island of Majorca (Spain). Molecular typing of HLA-B and HLA-DRB and quantification of serum levels of IgG antibodies to C. pneumoniae (sIgGa-Cp) were determined. Student's t-test, v 2 -statistics, logistic regression analysis, and general linear model ANOVA were used for statistical analysis. The results showed that EH was related with HLA-DRB3*0202 in the whole study population, and with levels of sIgGa-Cp463.5 BU/ ml in the group of individuals with sIgGa-Cp430 BU/ml (OR (95% CI) adjusted for obesity, familial history of EH and diabetes ¼ 2.06 (1.07-3.97), P ¼ 0.03, and ¼ 4.60 (1.06-19.90), P ¼ 0.04, respectively). The association between EH and sIgGa-Cp was observed in the DRB3*0202( þ ) individuals, but not in the DRB3*0202(À) subgroup (OR (95% CI) ¼ 11.14 (1.92-64.54), P ¼ 0.004, and ¼ 0.98 (0.22-4.43), P ¼ 0.64, respectively (P of the Mantel-Haenszel test for homogeneity of OR ¼ 0.06)). In our population, EH was positively associated with HLA-DRB3*0202 and with high levels of sIgGa-Cp. Moreover, a significant interaction of DRB3*0202 on the effect of sIgGa-Cp was observed, as the association of EH with these antibodies depended on the presence of DRB3*0202.

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“…There is evidence suggesting that adhesion of H. pylori to specific gastric surface epithelial class II HLA leads to a type 1 helper T-cell (Th1) predominant response that may determine disease outcome. Furthermore, epidemiological studies have shown that alleles from DQA1, DQB1, or DRB1 subregions may reduce or increase the risk for GC [16][17][18][19] or benign gastroduodenal disease [20], in different populations. On the other hand, cytokines associated with a Th1 response may modulate the development of atrophic gastritis and preneoplastic lesions in mice [15].…”

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confidence: 99%

Association of Helicobacter pylori‐related Distal Gastric Cancer with the HLA Class II Gene DQB1^0602 and cagA*⁺ Strains in a Southern European Population

Quintero¹,

Pizarro²,

Rodrigo³

et al. 2005

Helicobacter

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Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobacter pylori related diseases

Cited by 24 publications

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HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)

Association of Helicobacter pylori‐related Distal Gastric Cancer with the HLA Class II Gene DQB1^0602 and cagA*⁺ Strains in a Southern European Population

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Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobacter pylori related diseases

Cited by 24 publications

References 0 publications

HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)

Association of Helicobacter pylori‐related Distal Gastric Cancer with the HLA Class II Gene DQB1*0602 and cagA+ Strains in a Southern European Population

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Association of Helicobacter pylori‐related Distal Gastric Cancer with the HLA Class II Gene DQB1^0602 and cagA*⁺ Strains in a Southern European Population