Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration

Klimas, R.; Witticke, Diana; Fallah, Sarah El; Mikus, Gerd

doi:10.1517/17425255.2013.779669

Cited by 47 publications

(35 citation statements)

References 53 publications

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“…This variant affects about 3% of northern Europeans, 5 to 10% of southern Europeans, 1 to 2 % of Asians, and 10 to 30% of individuals from Arabian and northeast African countries [168]. However, it appears that oxycodone is unlikely to result in this reaction [169,170]. In addition to affecting the mother, opioids can result in sedation of the breastfed infant [171][172][173].…”

Section: Dopaminergicsmentioning

confidence: 99%

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Picchietti¹,

Hensley²,

Bainbridge³

et al. 2015

Sleep Medicine Reviews

139

106

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Section: Dopaminergicsmentioning

confidence: 99%

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Picchietti¹,

Hensley²,

Bainbridge³

et al. 2015

Sleep Medicine Reviews

139

106

View full text Add to dashboard Cite

“…More recently, Klimas and coworkers [46] demonstrated that OC itself is responsible for its analgesic effects. They found that although OCM and NOM have much higher affinity than OC for the μ‐opioid receptor, the OCM and NOM metabolite concentrations at the site of action are very low.…”

Section: Discussionmentioning

confidence: 99%

Personalized Oxycodone Dosing: Using Pharmacogenetic Testing and Clinical Pharmacokinetics to Reduce Toxicity Risk and Increase Effectiveness

Linares¹,

Daly²,

Linares³

et al. 2014

Pain Med

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Personalized oxycodone dosing is a new tool for a clinician treating chronic pain patients requiring oxycodone. By expressing a patient's CYP2D6 phenotype pharmacokinetically, a clinician (at least theoretically) can improve the safety and efficacy of oxycodone and decrease the risk for iatrogenically induced overdose or death. Pharmacokinomics provides a general framework for the integration of pharmacogenetics with clinical pharmacokinetics into clinical practice for gene-based prescribing.

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“…Oxycodone is eliminated by hepatic metabolism . While oxycodone has three pharmacologically active metabolites (oxymorphone, noroxymorphone, and noroxycodone), the parent drug appears to be the source of its analgesic effects . Intrathecal but not systemic administration of noroxymorphone may have analgesic effect .…”

Section: Oxycodone Pharmacologymentioning

confidence: 99%

Perspectives on Intravenous Oxycodone for Control of Postoperative Pain

et al. 2015

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Intravenous (IV) analgesia has particular advantages in the immediate postoperative period. For example, IV administration results in a faster onset of pain relief and results in more predictable pharmacokinetics than does administration by other routes. It also allows for convenient dosing before or during surgery, permitting the initiation of effective analgesia in the early phase of the postoperative period. In addition, when patients are able to tolerate oral intake, they can be switched from IV to oral dosing based on maintaining the predictable analgesia established by the IV route. IV morphine is widely used for the control of postoperative pain, but there is a trend toward the use of oxycodone. Oxycodone (which may be mediated partly through kappa- as well as mu-opioid receptors) offers several potential advantages. Published studies comparing IV oxycodone to other IV opioids for postsurgical pain report that oxycodone is a safe and effective analgesic. Some studies show that IV oxycodone may be associated with greater pain control, fewer or less severe adverse events, and faster onset of action, although the results are not consistent across all studies. Oxycodone has been reported to be safe in the geriatric and other special populations when adequate clinical adjustments are made. Thus, the clinical reports and oxycodone's pharmacologic profile make intravenous oxycodone a potentially important "new" old drug for postoperative pain control.

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Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration

Cited by 47 publications

References 53 publications

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Personalized Oxycodone Dosing: Using Pharmacogenetic Testing and Clinical Pharmacokinetics to Reduce Toxicity Risk and Increase Effectiveness

Perspectives on Intravenous Oxycodone for Control of Postoperative Pain

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