Contribution of the cornea and internal surfaces to the change of ocular aberrations with age

Artal, Pablo; Berrio, Esther; Guirao, Antonio; Piers, Patricia

doi:10.1364/josaa.19.000137

Cited by 425 publications

(283 citation statements)

References 16 publications

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“…In this study, since primarily the central region of the double-pass LSF was examined, aberrations and diffraction likely had a dominant role in determining the LSF shape. The results of the current study indicate broadening of the Lorentzian fitted curve with age, corresponding to previous studies that have reported increased aberrations due to aging in normal subjects (Hammond et al, 2000;Artal et al, 2002;Brunette et al, 2003;Amano et al, 2004). Also, the width of the LSF depends on pupil size and has been reported to vary by 1.8 arc min for pupil diameters in the range of 4.9~6.6 mm (Campbell and Gubisch, 1966).…”

Section: Discussionsupporting

confidence: 87%

Representing the retinal line spread shape with mathematical functions

Yang

Wanek

Shahidi

2008

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To report a mathematical function that characterizes the double-pass line spread function (LSF) of the human eye. Determining analytical functions that represent the double-pass LSF is important because it allows modeling the optical performance of the eye. Methods: Optical section retinal images, generated in normal human eyes using a modified slit-lamp biomicroscope, were analyzed to derive the double-pass LSF by plotting the intensity distribution of laser light reflected/ scattered from the vitreoretinal interface. Three mathematical functions (Lorentzian, Gaussian, exponential) were fitted to the double-pass LSF and the root mean square error (RMSE) was calculated to provide a measure of the goodness of fit. Results: The Lorentzian function provided the best representation of the double-pass LSF of normal human eyes. The full width at half maximum (FWHM) of the Lorentzian fitted curve was positively correlated with age, indicating that the double-pass LSF broadens with age. Furthermore, the goodness of fit of the Lorentzian function was significantly better in younger subjects as compared with older subjects, suggesting that the fitted function to the double-pass LSF may vary according to age. Conclusion: The results demonstrate an age-related change in the double-pass LSF width and the goodness of fit of the Lorentzian function.

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Section: Discussionsupporting

confidence: 87%

Representing the retinal line spread shape with mathematical functions

Yang

Wanek

Shahidi

2008

J. Zhejiang Univ. Sci. B

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“…We included the internal HOAs because the crystalline lens is responsible for the increase in ocular aberrations that occurs with aging. 1,11,23 In our study, the RMS HOAs in the entire eye were lower than in the internal optics, indicating the presence of nuclear sclerosis. Coma was the most predominant HOA in our study.…”

Section: Discussionmentioning

confidence: 44%

Scheimpflug lens densitometry and ocular wavefront aberrations in patients with mild nuclear cataract

Faria-Correia¹,

Lopes²,

Monteiro³

et al. 2016

Journal of Cataract and Refractive Surgery

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PURPOSE:To test correlations between Scheimpflug optical densitometry and ocular higher-order aberrations (HOAs) in patients with mild nuclear cataract.SETTING: Cornea and Refractive Surgery Department, Hospital de Braga, Braga, Portugal. DESIGN:Retrospective single-center study. METHODS:In eyes with mild nuclear cataract, lens densitometry was evaluated by Scheimpflug imaging (Pentacam HR), which provided an objective quantification (mean density and maximum density) and grading (nuclear staging score) of the crystalline lens. A visual function analyzer that combines ray-tracing aberrometry and Placido disk-based topography (iTrace) was used to evaluate the total ocular and internal HOAs. RESULTS:The study comprised 40 eyes of 30 patients. The mean density of the lens nucleus was 8.99% G 0.76% (SD) (range 7.5% to 10.8%), and the mean maximum density was 27.96% G 6.97% (range 16.9% to 56.1%). Regarding the score of nuclear staging of the Scheimpflug device, 28 eyes had level 0 and 12 eyes had level 1. Significant positive correlations were found between the mean density and maximum density parameters and the internal HOAs (r Z 0.661, P < .001 and r Z 0.570, P < .001, respectively).CONCLUSIONS: There were significant correlations between the quantification parameters derived from Scheimpflug lens densitometry and ocular HOAs. The integration of these technologies can help in clinical decision making and in understanding the subjective symptoms of patients with mild nuclear cataracts.

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“…5,6 Therefore, the total ocular aberration increases with age, leading to deterioration of optical quality in older subjects. [7][8][9][10] When the crystalline lens is replaced by an intraocular lens (IOL) in cataract surgery, further changes may occur. It has been shown that ocular higher-order aberration in pseudophakic eyes is comparable with that in phakic eyes of subjects of the same age.…”

Section: Introductionmentioning

confidence: 99%

Correlation of higher-order wavefront aberrations with visual function in pseudophakic eyes

Hayashi

Yoshida

Hayashi

2007

Eye

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Aim To study the correlation between higher-order wavefront aberrations and visual function in eyes with a spherical monofocal intraocular lens (IOL), and to see if the aberrations differ between eyes that received different types of IOLs. Methods One hundred forty-eight eyes of 148 patients who underwent phacoemulsification and implantation of one of five types of acrylic IOL were enrolled. At 1 month after surgery, ocular aberrations were measured using a Hartmann-Shack aberrometer and corneal aberrations were measured using videokeratography. In addition, the aberration of internal optics was determined by subtracting the corneal aberration from the ocular aberration. These aberrations were correlated with visual acuity and with contrast visual acuity under both photopic and mesopic conditions. Results Ocular, corneal, and internal optic aberrations (total aberration, coma, and spherical aberration) were all correlated significantly with visual acuity, as well as with photopic and mesopic contrast visual acuity. The associations between internal optic aberrations and visual function tended to be stronger than were those of corneal aberrations. Furthermore, ocular aberrations differed significantly between eyes with the five different IOLs (Pp0.0078). Specifically, the internal optic spherical aberration was markedly significantly different between eyes (P ¼ 0.0142), and the corneal coma showed a marginally significant difference (P ¼ 0.0421). Conclusion Ocular, corneal, and internal optic higher-order wavefront aberrations are correlated significantly with visual function in eyes with a spherical monofocal IOL. The spherical aberration of the internal optics and coma of the cornea vary between eyes with different types of IOL.

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Contribution of the cornea and internal surfaces to the change of ocular aberrations with age

Cited by 425 publications

References 16 publications

Representing the retinal line spread shape with mathematical functions

Representing the retinal line spread shape with mathematical functions

Scheimpflug lens densitometry and ocular wavefront aberrations in patients with mild nuclear cataract

Correlation of higher-order wavefront aberrations with visual function in pseudophakic eyes

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