Contribution of the gastrointestinal tract below the stomach to the 13C-urea breath test

Lee, Tae Hoon; Yang, Jyh‐Chin; Sc, Lee; Ss, Farn; Th, Wang

doi:10.1016/s1590-8658(03)00266-4

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…introduced 13 C‐urea directly in the duodenum, but they obtained results similar to those obtained with the standard protocol excluding the participation of intestinal bacteria. No late rise in 13 CO 2 was observed even up to 180 minutes after administration of labeled urea [42]. The impact of proton pump inhibitor (PPI) treatment is still a subject of interest.…”

Section: Urea Breath Testmentioning

confidence: 99%

Diagnosis of Helicobacter pylori Infection

et al. 2004

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While there are some attempts to improve culture of Helicobacter pylori, molecular methods have been the main focus of this interest. Their main application concerns the development of rapid tests also allowing the determination of bacterial resistance, i.e. real-time polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH), or to genotype the strains. Attempts to improve, simplify or explain the discrepancies of urea breath test results have been made and new generation of stool antigen test with monoclonal antibodies either using the standard ELISA format or rapid immunoenzymatic detection have confirmed their value. With regard to serology, studies have mainly focused on the distinction of infections with more pathogenic strains and the ability to diagnose atrophic gastritis with the Gastropanel.

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Section: Urea Breath Testmentioning

confidence: 99%

Diagnosis of Helicobacter pylori Infection

et al. 2004

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“…Conversely, T-H Lee et al . 19 did not find any late rise after direct administration of the test urea into the duodenum up to 180 min in H. pylori -negative or -positive patients using similar procedures. However, there are some important differences between the two studies.…”

Section: Discussionmentioning

confidence: 68%

Influence of urease activity in the intestinal tract on the results of ¹³C‐urea breath test

Urita

Hike

Torii

et al. 2006

J of Gastro and Hepatol

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“…We proposed that release of 13 C-urea in the caecum or colon (urease-rich segment) from oral colon-targeted capsules would lead to fermentation of 13 C-urea by bacterial urease into 13 CO2 (Lee et al, 2003;Urita et al, 2006). Subsequent absorption of 13 CO2 into the blood and circulation would lead to detectable 13 C (as 13 CO2) in breath.…”

Section: Introductionmentioning

confidence: 99%

“…We proposed that release of 13 C‐urea in the caecum or colon (urease‐rich segment) from oral colon‐targeted capsules would lead to fermentation of 13 C‐urea by bacterial urease into 13 CO 2 (Lee et al. , 2003; Urita et al.…”

Section: Introductionmentioning

confidence: 99%

Proof‐of‐concept study on the suitability of ¹³C‐urea as a marker substance for assessment of in vivo behaviour of oral colon‐targeted dosage forms

Schellekens

Olsder

Langenberg

et al. 2009

British J Pharmacology

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Background and purpose:13 C-urea may be a suitable marker to assess the in vivo fate of colon-targeted dosage forms given by mouth. We postulated that release in the colon (urease-rich segment) of 13 C-urea from colon-targeted capsules would lead to fermentation of Conclusions and implications:In this proof-of-concept study, 13 C-urea was able to provide information on both the release kinetics of a colon-targeted oral dosage form and the gastrointestinal segment where it was released.

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Contribution of the gastrointestinal tract below the stomach to the 13C-urea breath test

Cited by 4 publications

References 9 publications

Diagnosis of Helicobacter pylori Infection

Diagnosis of Helicobacter pylori Infection

Influence of urease activity in the intestinal tract on the results of ¹³C‐urea breath test

Proof‐of‐concept study on the suitability of ¹³C‐urea as a marker substance for assessment of in vivo behaviour of oral colon‐targeted dosage forms

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Contribution of the gastrointestinal tract below the stomach to the 13C-urea breath test

Cited by 4 publications

References 9 publications

Diagnosis of Helicobacter pylori Infection

Diagnosis of Helicobacter pylori Infection

Influence of urease activity in the intestinal tract on the results of 13C‐urea breath test

Proof‐of‐concept study on the suitability of 13C‐urea as a marker substance for assessment of in vivo behaviour of oral colon‐targeted dosage forms

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Influence of urease activity in the intestinal tract on the results of ¹³C‐urea breath test

Proof‐of‐concept study on the suitability of ¹³C‐urea as a marker substance for assessment of in vivo behaviour of oral colon‐targeted dosage forms