Contribution of the left and right inferior frontal gyrus in recovery from aphasia. A functional MRI study in stroke patients with preserved hemodynamic responsiveness

Oers, C.A.M.M. van; Vink, Matthijs; Zandvoort, M.J.E. van; Worp, H. Bart van der; Haan, Edward H.F. de; Kappelle, L. Jaap; Ramsey, Nick F.; Dijkhuizen, Rick M.

doi:10.1016/j.neuroimage.2009.08.057

Cited by 107 publications

(104 citation statements)

References 44 publications

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“…The hypothesis of an incomplete aphasia amelioration sustained mainly by the right-sided language-related areas, particularly by the right IFG (right Broca jomologue) and, conversely, a better outcome related to activation in left perilesional areas, has been sustained by many authors, 7,11,30,37,38 if not all, 39 when examining chronic aphasics. Only in some patients, right IFG activation would be essential for residual language function; however, its compensatory potential would be less effective than in patients who recover left IFG function.…”

Section: Strokementioning

confidence: 99%

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Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Mattioli

Ambrosi

Mascaro

et al. 2014

Stroke

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A n important issue for language rehabilitation after stroke is the relationship between the effects of therapeutic interventions and the functional changes observed in brain language-related areas. Most studies focused on the spontaneous recovery of language, [1][2][3][4][5][6][7] but only a few, often single case descriptions, focused on patients submitted to language rehabilitation. [8][9][10][11][12][13] All of these were conducted on chronic patients. The rate of complete spontaneous (ie, without language therapy) aphasia recovery poststroke has been estimated at ≈33% in the first month, 43% after 4 months, and 50% 12 months later.14 However, the concept of spontaneous recovery of language may not be appropriate (as human beings are extensively exposed to language). The term language therapy commonly relates to formal interventions provided by speech therapists aimed at improving different language abilities with specific exercises.Evidence supports the use of language rehabilitation in stroke, particularly if intensively administered for short courses in chronic aphasics. 15,16 In a pilot study, Godecke et al 17 found that daily aphasia therapy in early stroke, that is, mean 3 days poststroke (dps), resulted in improved communication outcomes in moderate to severe aphasia. Brain plasticity induced by language training has not been extensively investigated to date. Several studies, conducted in chronic patients, suggested that functional correlates of aphasia recovery could be either the activation of predominantly left hemisphere (LH) language-related areas [18][19][20][21][22] or of the homologous right hemisphere (RH) areas, 2,23-25 but often the authors do not clarify whether patients were formally treated and to what extent, or not. Saur et al 4 suggest that in the postacute stages of recovery (2 weeks poststroke), the LH areas would be reduced in activation, whereas after months Background and Purpose-Early poststroke aphasia rehabilitation effects and their functional MRI (fMRI) correlates were investigated in a pilot, controlled longitudinal study. Methods-Twelve patients with mild/moderate aphasia (8 Broca, 3 anomic, and 1 Wernicke) were randomly assigned to daily language rehabilitation for 2 weeks (starting 2.2 [mean] days poststroke) or no rehabilitation. The Aachen Aphasia Test and fMRI recorded during an auditory comprehension task were performed at 3 time intervals: mean 2.2 (T1), 16.2 (T2), and 190 (T3) days poststroke. Results-Groups did not differ in terms of age, education, aphasia severity, lesions volume, baseline fMRI activations, and in task performance during fMRI across examinations. Rehabilitated patients significantly improved in naming and written language tasks (P<0.05) compared with no rehabilitation group both at T2 and T3. Functional activity at T1 was reduced in language-related cortical areas (right and left inferior frontal gyrus and middle temporal gyrus, right inferior parietal lobule and superior temporal gyrus) in patients compared with controls. T2 and T3 follow-ups r...

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Section: Strokementioning

confidence: 99%

“…Most studies focused on the spontaneous recovery of language, [1][2][3][4][5][6][7] but only a few, often single case descriptions, focused on patients submitted to language rehabilitation. [8][9][10][11][12][13] All of these were conducted on chronic patients.…”

mentioning

confidence: 99%

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Mattioli

Ambrosi

Mascaro

et al. 2014

Stroke

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“…As most cognitive functions are asymmetrically implemented in the brain [Formisano et al, 2008;Hickok and Poeppel, 2007;Hugdahl, 2000], the engagement of the contralateral cortex may be less efficient than the primary functional organization, and hence maladaptive [Kell et al, 2009;Marsh and Hillis, 2006;Martin and Ayala, 2004;Naeser et al, 2005;Preibisch et al, 2003;van Oers et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

Bilateral reorganization of posterior temporal cortices in post‐lingual deafness and its relation to cochlear implant outcome

Lazard

Lee

Truy

et al. 2012

Human Brain Mapping

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Post-lingual deafness induces a decline in the ability to process phonological sounds or evoke phonological representations. This decline is paralleled with abnormally high neural activity in the right posterior superior temporal gyrus/supramarginal gyrus (PSTG/SMG). As this neural plasticity negatively relates to cochlear implantation (CI) success, it appears important to understand its determinants. We addressed the neuro-functional mechanisms underlying this maladaptive phenomenon using behavioral and functional magnetic resonance imaging (fMRI) data acquired in 10 normal-hearing subjects and 10 post-lingual deaf candidates for CI. We compared two memory tasks where subjects had to evoke phonological (speech) and environmental sound representations from visually presented items. We observed dissociations in the dynamics of right versus left PSTG/SMG neural responses as a function of duration of deafness. Responses in the left PSTG/SMG to phonological processing and responses in the right PSTG/ SMG to environmental sound imagery both declined. However, abnormally high neural activity was observed in response to phonological visual items in the right PSTG/SMG, i.e., contralateral to the zone where phonological activity decreased. In contrast, no such responses (overactivation) were observed in the left PSTG/SMG in response to environmental sounds. This asymmetry in functional adaptation to deafness suggests that maladaptive reorganization of the right PSTG/SMG region is not due to balanced hemispheric interaction, but to a specific take-over of the right PSTG/SMG region by phonological processing, presumably because speech remains behaviorally more relevant to communication than the processing of environmental sounds. These results demonstrate that cognitive long-term alteration of auditory processing shapes functional cerebral reorganization. Hum Brain Mapp 00:000-000,

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“…Это говорит о том, что и в норме правое полу-шарие участвует в некоторой степени в обеспечении речевой функции. Следовательно, несмотря на то что правое полушарие ограничено в компенсации речевых нарушений при поражении левого, оно мо-жет компенсировать отдельные стороны речевой функции, например нелингвистические процессы [1,9]. При отсутствии речевой деятельности А. Thiel и соавт.…”

Section: Discussionunclassified

“…Восстановление речи происходит гораздо успешнее через интеграцию до-ступных, имеющихся в распоряжении регионов ле-вого полушария, чем через подключение новых от-делов мозга в правом полушарии. Правое полушарие при этом может более активно подключаться к вос-становлению понимания речи [8], отвечать за не-лингвистические процессы при восстановлении ре-чи [1,2,9] либо за продуцирование и понимание простых слов [10,11]. При этом подчеркивается большая индивидуальность межполушарной орга-низации речевой системы [12].…”

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Dynamics of functional MRI and speech function in patients after resection of frontal and temporal lobe tumors

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Баталов

et al. 2017

Vopr. neirokhir.

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Contribution of the left and right inferior frontal gyrus in recovery from aphasia. A functional MRI study in stroke patients with preserved hemodynamic responsiveness

Cited by 107 publications

References 44 publications

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Early Aphasia Rehabilitation Is Associated With Functional Reactivation of the Left Inferior Frontal Gyrus

Bilateral reorganization of posterior temporal cortices in post‐lingual deafness and its relation to cochlear implant outcome

Dynamics of functional MRI and speech function in patients after resection of frontal and temporal lobe tumors

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