Contribution of the Pro12Ala polymorphism of peroxisome proliferator-activated receptor Ɣ2 gene in relation to obesity

Zahri, Mohd Khairi; Antonucci, Emilia; Rawi, Rohayu Izanwati Mohd; Taib, Wan Rohani Wan; Sani, Aliya Irshad; Baig, Atif Amin

doi:10.1016/j.mgene.2016.09.008

“…The results showed a significant association between the Pro12Ala variant in the PPARγ gene with BMI status, suggesting the role of the Pro12Ala variant in the PPARγ gene in overweight Malay children [ 88 ]. This was supported by a cross-sectional study conducted among Malay adults demonstrating that the Pro12Ala of the PPARγ gene was closely associated with obesity, as shown by the Ala12 carriers had a significantly higher BMI [ 89 ]. Contradictory to the study by Rahman et al in a population of children, a previous study by Dedoussis et al among Greek pre-adolescents demonstrated no significant association between Pro12Ala PPARγ gene mutation and BMI status [ 90 ].…”

Section: The Role Of Cholesterol-related Genes In Obesitymentioning

confidence: 79%

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Wong

¹

,

Ramli

²

,

Ali

³

et al. 2022

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Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessive nutrients and sedentary lifestyle are modifiable and could be improved by lifestyle modification. However, genetic susceptibility to MetS, a non-modifiable factor, has attracted the attention of researchers, which could act as the basis for future diagnosis, prognosis, and therapy for MetS. Several cholesterol-related genes associated with each characteristic of MetS have been identified, such as apolipoprotein, lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and adiponectin. This review aims to summarize the genetic information of cholesterol-related genes in MetS, which may potentially serve as biomarkers for early prevention and management of MetS.

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“…Therefore, various metabolic diseases also can have high chances of high cfDNA level in circulation according to hypothesis of related cfDNA with oxidative stress. The significant disorders might be associated with cfDNA are mertabolic diseases high oxidative stress, for example, obesity and diabetes [47][48][49]. Studies are required in future to look into the effect of severity of metabolomics stress and oxidative stress on cfDNA [50].…”

Section: Circulating Cell-free Dnamentioning

confidence: 99%

Obesity Leads to Elevated Level of Circulating Cell-Free DNA

Ab

¹

2018

CTBEB

1

0

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With the steadily growing number of studies in the issues related to obesity research, it is proven, that obesity might be related to wide number of body disorders, some of these disorders have been already studied and investigated, and some still needed more investigations, which has opened new horizons to unlimite hypotheses about involvement of obesity in many physiological disorders. In the current opinion, we hypothesized to the conclusion that there is a correlation between obesity severity and elevated cfDNA levels in the circulation. This correlation is based on free radicals and oxidative stress hypothesis of cellular and molecular damage in cell injury, which in turn leads to a disorder in the whole body and enhances the inflammatory status.

show abstract

“…Therefore, various metabolic diseases also can have high chances of high cfDNA level in circulation according to hypothesis of related cfDNA with oxidative stress. The significant disorders might be associated with cfDNA are mertabolic diseases high oxidative stress, for example, obesity and diabetes [47][48][49]. Studies are required in future to look into the effect of severity of metabolomics stress and oxidative stress on cfDNA [50].…”

Section: Circulating Cell-free Dnamentioning

confidence: 99%

Obesity Leads to Elevated Level of Circulating Cell-Free DNA

Baig

2018

CTBEB

0

View full text Add to dashboard Cite

With the steadily growing number of studies in the issues related to obesity research, it is proven, that obesity might be related to wide number of body disorders, some of these disorders have been already studied and investigated, and some still needed more investigations, which has opened new horizons to unlimite hypotheses about involvement of obesity in many physiological disorders. In the current opinion, we hypothesized to the conclusion that there is a correlation between obesity severity and elevated cfDNA levels in the circulation. This correlation is based on free radicals and oxidative stress hypothesis of cellular and molecular damage in cell injury, which in turn leads to a disorder in the whole body and enhances the inflammatory status.

show abstract

Contribution of the Pro12Ala polymorphism of peroxisome proliferator-activated receptor Ɣ2 gene in relation to obesity

Cited by 4 publications

References 46 publications

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Obesity Leads to Elevated Level of Circulating Cell-Free DNA

Obesity Leads to Elevated Level of Circulating Cell-Free DNA

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