Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

Steven, André; Seliger, Barbara

doi:10.18632/oncotarget.7721

Cited by 114 publications

(112 citation statements)

References 106 publications

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“…CRE B induced the robust expression of miR-132 in U87 cell lines. Previous studies reported that CRE B is an oncogene, which is related to tumor progression and patients' survival [39]. The CREB-miR-132 signaling pathway remains worthy of further study.…”

Section: Discussionmentioning

confidence: 92%

MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro

Geng

et al. 2016

J Neurooncol

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Gliomas are highly malignant tumors, the most common of which are astrocytomas. A growing number of studies suggest that dysregulation of miRNAs is a frequent event contributing to the pathogenesis of gliomas. In this study, we found that over-expression of miR-132 inhibited cell proliferation and migration and triggered apoptosis, while knockdown of miR-132 showed opposite effects. PEA-15 was identified as a direct target of miR-132. Reintroduction of PEA-15 without 3'UTR region reversed the inhibitory effects of miR-132 on cell proliferation, migration, and apoptosis. MiR-132 was inversely correlated with the PEA-15 expression. CREB (cAMP response element binding protein) and KLF (Krüppel-like factor 8) were conformed as transcription factors of miR-132, which bidirectionally regulate the expression of miR-132. Our study suggests that miR-132 is an important tumor suppressor of astrocytoma progression by targeting PEA-15, while CREB and KLF can modulate the expression of miR-132, thus providing new insight into the molecular mechanisms underlying astrocytoma progression in vitro.

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Section: Discussionmentioning

confidence: 92%

MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro

Geng

et al. 2016

J Neurooncol

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“…Although the detailed mechanisms of CnP remain unclear, a previous report showed that CnP inhibits cAMP‐responsive element binding protein (CREB) activation . CREB is a crucial transcription factor, which regulates a wide range of biological processes to orchestrate proper cell differentiation and cell growth . Moreover, CREB has previously been shown to regulate inflammatory responses by directly regulating gene transcription of proinflammatory genes, such as IL‐6 and TNF‐α, and CREB silencing has been shown to reduce the levels of IL‐6, IL‐8, and CCL2 in malignant mesothelioma cells .…”

Section: Discussionmentioning

confidence: 99%

Conophylline suppresses pancreatic cancer desmoplasia and cancer‐promoting cytokines produced by cancer‐associated fibroblasts

et al. 2018

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Despite recent advances in cancer treatment, pancreatic cancer is a highly malignant tumor type with a dismal prognosis and it is characterized by dense desmoplasia in the cancer tissue. Cancer‐associated fibroblasts (CAF) are responsible for this fibrotic stroma and promote cancer progression. We previously reported that a novel natural compound conophylline (CnP) extracted from the leaves of a tropical plant reduced liver and pancreatic fibrosis by suppression of stellate cells. However, there have been no studies to investigate the effects of CnP on CAF, which is the aim of this work. Here, we showed that CAF stimulated indicators of pancreatic cancer malignancy, such as proliferation, invasiveness, and chemoresistance. We also showed that CnP suppressed CAF activity and proliferation, and inhibited the stimulating effects of CAF on pancreatic cancer cells. Moreover, CnP strongly decreased the various cytokines involved in cancer progression, such as interleukin (IL)‐6, IL‐8, C‐C motif chemokine ligand 2 (CCL2), and C‐X‐C motif chemokine ligand 12 (CXCL12), secreted by CAF. In vivo, CAF promoted tumor proliferation and desmoplastic formation in a mouse xenograft model, CnP reduced desmoplasia of tumors composed of pancreatic cancer cells + CAF, and combination therapy of CnP with gemcitabine remarkably inhibited tumor proliferation. Our findings suggest that CnP is a promising therapeutic strategy of combination therapy with anticancer drugs to overcome refractory pancreatic cancers.

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“…Therefore, it is urgent to find new therapeutic targets. CREB belongs to basic/leucine zipper (bZIP) transcription factor family (22) and is described as a proto-oncogene (6,23). CREB play an important role at early stage of papilloma formation (24), promoted abnormal proliferation of myeloid cells in vitro and in vivo and was implicated in myeloid cell transformation (6).…”

Section: Discussionmentioning

confidence: 99%

Targeting the overexpressed CREB inhibits esophageal squamous cell carcinoma cell growth

Chen

Hao

et al. 2017

Oncol Rep

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Abstract. Although several studies highlight the important role of cAMP-responsive element binding protein (CREB) in tumor progression, little is known concerning the expression and function of CREB in esophageal cancer. In the present study, the expression of CREB was evaluated using a human esophageal squamous cell carcinoma tissue array by immunohistochemical analysis, which was confirmed by western blot analysis of tissues from esophageal cancer, and adjacent esophageal tissue. The role of CREB on esophageal cancer cell growth was analyzed in vitro and in vivo. Results showed that CREB was overexpressed in esophageal squamous cell carcinomas tissues, which was positively correlated with lymph node metastasis and tumor-node-metastasis (TNM) stage of esophageal cancer patients. Downregulating the expression of CREB effectively reduced esophageal cell growth in vitro and in vivo, induced S phase cell cycle arrest, triggered apoptosis and inhibited cell migration and invasion. These findings suggested CREB as an attractive drug target for esophageal cancer.

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Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic target

Cited by 114 publications

References 106 publications

MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro

MicroRNA-132 targets PEA-15 and suppresses the progression of astrocytoma in vitro

Conophylline suppresses pancreatic cancer desmoplasia and cancer‐promoting cytokines produced by cancer‐associated fibroblasts

Targeting the overexpressed CREB inhibits esophageal squamous cell carcinoma cell growth

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