Control of methicillin-resistant Staphylococcus aureus outbreak involving several hospitals

Pastila, Satu; Sammalkorpi, Kari; Vuopio‐Varkila, Jaana; Kontiainen, Sirkka; Ristola, Matti

doi:10.1016/j.jhin.2004.06.024

Cited by 13 publications

(11 citation statements)

References 13 publications

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“…A "search and destroy" method, a difficult but intuitively sensible task to perform (PASTILA et al, 2004;FARIA et al, 2005) when used together in a concerted manner (VOSS, 2004), is a multipronged approach to keeping MRSA infection prevalence low.…”

Section: Introductionmentioning

confidence: 99%

In vitro inhibitory effects of the ethanol extract of Tetrapleura tetraptera (Schum and thonn.) taub. against multidrug resistant staphylococcus aureus

Olajuyigbe¹,

Afolayan²

2018

Kragujevac J Science

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ABSTRACT. In this study, the antibacterial effect of ethanol extract of Tetrapleura tetraptera was investigated in vitro against methicillin-resistant Staphylococcus aureus by agar diffusion and macrobroth dilution methods. At the lowest concentration of 20 mg/ml of the ethanol extract, 100 µl produced inhibition zones that ranged between 06 and 15 ± 1.0 mm while the inhibition zones ranged between 16 ± 1.0 mm and 22 ± 1.0 mm when the isolates were tested with 100 µl of the highest concentration (100 mg/ml) of ethanol extract. The minimum inhibitory concentrations (MICs) of the ethanol extract were between 0.019 mg/ml and 5.0 mg/ml while its minimum bactericidal concentrations (MBCs) ranged between 0.078 and 10.0 mg/ml. Ten strains had their MICs less than 1.0 mg/ml while the remaining S. aureus strains had their MICs at concentrations ranging between 1.25 mg/ml and 5.0 mg/ml. The degree of antibacterial activity exhibited by the extract of T. tetraptera demonstrated that its herbal medicine could be as effective as modern medicine in treating diseases associated with the test pathogenic organism and justifying its traditional use in the treatment of bacterial infections.

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Section: Introductionmentioning

confidence: 99%

In vitro inhibitory effects of the ethanol extract of Tetrapleura tetraptera (Schum and thonn.) taub. against multidrug resistant staphylococcus aureus

Olajuyigbe¹,

Afolayan²

2018

Kragujevac J Science

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“…Scandinavian countries and The Netherlands, however, have maintained prevalence levels of nosocomial MRSA infections Ͻ1% (1,(4)(5)(6)(7)(8), presumably because of nationwide policies to identify MRSA carriage and specific infection control measures for managing colonized patients. This so-called ''search & destroy'' (S&D) policy was implemented in the 1980s.…”

mentioning

confidence: 99%

Controlling methicillin-resistant Staphylococcus aureus : Quantifying the effects of interventions and rapid diagnostic testing

Bootsma

Diekmann

Bonten

2006

Proc. Natl. Acad. Sci. U.S.A.

254

224

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Control of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) has been unsuccessful in most countries. Yet, some countries have maintained low endemic levels by implementing nationwide MRSA-specific infection control measures, such as ''search & destroy'' (S&D). These strategies, however, are not based on well designed studies, and their use in countries with high levels of endemicity is controversial. We present a stochastic three-hospital model and an analytical one-hospital model to quantify the effectiveness of different infection control measures and to predict the effects of rapid diagnostic testing (RDT) on isolation needs. Isolation of MRSA carriers identified by clinical cultures is insufficient to control MRSA. However, combined with proactive search (of high-risk patients on admission and͞or contacts of index patients), it will maintain prevalence levels <1%. Concerted implementation of S&D in countries with high nosocomial endemicity reduces nosocomial prevalence to <1% within 6 years. Stepwise implementation of control measures can reduce isolation capacities needed. RDT can reduce isolation needs by >90% in low-endemic settings and by 20% in high-endemic settings. Surveillance of colonization and improved hand hygiene can markedly increase control efficacy. These findings strongly suggest that: (i) causality exists between S&D and low MRSA prevalence; (ii) isolating MRSA carriers identified by clinical cultures as a single measure is insufficient for control; (iii) a combined approach of isolation and screening confers efficacy; and (iv) MRSA-prevalence levels can be reduced to <1% in high-endemic settings by S&D or a stepwise approach to interventions. RDT can markedly enhance feasibility.infection control ͉ mathematical model ͉ search & destroy ͉ antibiotic resistance

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“…12 Patients carrying MRSA may, therefore, be admitted to hospitals without being screened. 2e4, 6,10,11,13 This may increase the risk of hospital spread of MRSA and presents a health risk for all patients because of treatment failure and adverse effects of non-beta-lactam antibiotic therapy. 5,6,8,9,15,17,20,22,25,29e33 In addition, the increased incidence of MRSA may be a health economic challenge because of longer hospital stay, isolation regimens, more surgery and more costly antimicrobial therapy.…”

Section: Introductionmentioning

confidence: 99%

“…5,6,8,9,15,17,20,22,25,29e33 In addition, the increased incidence of MRSA may be a health economic challenge because of longer hospital stay, isolation regimens, more surgery and more costly antimicrobial therapy. 6,23 The aim of this study was to determine if an outbreak of MRSA in a setting with multi-handicapped children and staff with close physical contact could be controlled successfully.…”

Section: Introductionmentioning

confidence: 99%

Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution

Jensen¹,

Jensen²,

Larsen³

et al. 2006

Journal of Hospital Infection

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Control of methicillin-resistant Staphylococcus aureus outbreak involving several hospitals

Cited by 13 publications

References 13 publications

In vitro inhibitory effects of the ethanol extract of Tetrapleura tetraptera (Schum and thonn.) taub. against multidrug resistant staphylococcus aureus

In vitro inhibitory effects of the ethanol extract of Tetrapleura tetraptera (Schum and thonn.) taub. against multidrug resistant staphylococcus aureus

Controlling methicillin-resistant Staphylococcus aureus : Quantifying the effects of interventions and rapid diagnostic testing

Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution

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