Control of postprandial hyperglycaemia by galactosyl maltobionolactone and its novel anti-amylase effect in mice

Murai, Atsushi; Iwamura, Koji; Takada, Masayasu; Ogawa, Koichi; Usui, Taichi; Okumura, J.

doi:10.1016/s0024-3205(02)01844-1

Cited by 65 publications

(35 citation statements)

References 23 publications

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“…Inflammatory bowel disease is a relative contraindication (4). There are also reports of an increased of renal tumors occurrence and serious hepatic injury and acute hepatitis (46).…”

Section: Phytoconstituents With -Amylase Inhibitory Activitymentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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-Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. Plants are an important source of chemical constituents with potential for inhibition of α-amylase and can be used as therapeutic or functional food sources. A review about crude extracts and isolated compounds from plant source that have been tested for α-amylase inhibitory activity has been done. The analysis of the results shows a variety of crude extracts that present α-amylase inhibitory activity and some of them had relevant activity when compared with controls used in the studies. Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound. Several phyto-constituents and plant species as α-amylase inhibitors are being reported in this article. Majority of studies have focused on the anti-amylase phenolic compounds.

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“…Inflammatory bowel disease is a relative contraindication (4). There are also reports of an increased of renal tumors occurrence and serious hepatic injury and acute hepatitis (46).…”

Section: Phytoconstituents With -Amylase Inhibitory Activitymentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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“…Commercially available antidiabetic drugs such as sitagliptin and saxagliptin are used for DPP-IV inhibition (Bharti et al 2012). Although powerful synthetic α-amylase, α-glucosidase and DPP-IV inhibitors including acarbose, voglibose, sitagliptin and saxagliptin are available, they are known to cause hepatic disorders and other gastrointestinal symptoms (Murai et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Unnikrishnan

Suthindhiran

Jayasri

2015

Frontiers in Life Science

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Two edible seaweeds, Sargassum polycystum and Sargassum wightii, were investigated for their antidiabetic potential using in vitro enzyme inhibitory assays. Among the various extracts, petroleum ether and ethyl acetate extracts of S. wightii showed significant inhibitory effects against α-amylase (IC 50 378.3 μg/ml) and α-glucosidase (IC 50 314.8 μg/ml). Methanol extract of S. wightii showed the highest inhibition against dipeptidyl peptidase-IV (DPP-IV) (IC 50 38.27 μg/ml) and moderate antioxidant activity was observed in acetone extract of S. wightii (44%). Similarly, ethyl acetate extract of S. polycystum showed the highest inhibition against α-amylase (IC 50 438.5 μg/ml) and methanol extract of S. polycystum showed maximum inhibition against α-glucosidase (IC 50 289.7 μg/ml) and DPP-IV (36.94 μg/ml). The antioxidant activity was poor (22%). The extracts were investigated for in vitro cytotoxicity, DNA fragmentation in macrophages and haemolytic activity against erythrocytes, but no notable toxicity was observed with any of the tested extracts. Gas chromatography-mass spectrometry revealed the presence of the antidiabetic compound fucosterol and other major bioactive compounds, giving an insight into the antidiabetic and antioxidant properties of these algae. This study reveals the possible mechanisms of antidiabetic action in vitro, and these two seaweeds may also have an antidiabetic action in vivo.

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“…Single-approach methods to treat diabetes have not yet been developed (Kumar, Narwal, Kumar, & Prakash, 2011;Murai et al, 2002;Vats, Kumar, Kothari, Mital, & Ramachandran, 2005); as such, combined therapeutic strategies should be established to treat this disease. Furthermore, substances and methodologies used in traditional Chinese medicine differ from those in modern medicine.…”

Section: Introductionmentioning

confidence: 99%

Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch)

Guo

Niu

Xiao

et al. 2015

Journal of Functional Foods

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Control of postprandial hyperglycaemia by galactosyl maltobionolactone and its novel anti-amylase effect in mice

Cited by 65 publications

References 23 publications

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

Antidiabetic potential of marine algae by inhibiting key metabolic enzymes

Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch)

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