Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders

Minzenberg, Michael; Lesh, Tyler A.; Niendam, Tara A.; Yoon, Jangho; Cheng, Yaoan; Rhoades, Remy N.; Carter, Cameron S.

doi:10.1016/j.jad.2015.08.049

Cited by 62 publications

(59 citation statements)

References 54 publications

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“…Two studies did not include a nonsuicidal group (Burton, Vella, Weller, & Twamley, 2011;Minzenberg et al, 2015c). The most common psychiatric diagnoses were depression in seven studies Dombrovski et al, 2010Dombrovski et al, , 2011Gujral et al, 2014Gujral et al, , 2016Richard-Devantoy, Szanto, et al, 2014;Szanto et al, 2015), schizophrenia or schizoaffective disorders in three studies (Delaney et al, 2012;Minzenberg et al, 2015bMinzenberg et al, , 2015c, psychotic mood disorder in one study (Minzenberg et al, 2015a), a variety of psychiatric disorders in one study (Burton et al, 2011), and unspecified psychiatric diagnoses in one study (Naifeh et al, 2017). Mean age of participants ranged from 21.1 to 71.4 years of age, with a median age of 66.8.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Intelligence was assessed in six studies (Burton et al, 2011;Delaney et al, 2012;Minzenberg et al, 2015aMinzenberg et al, , 2015bMinzenberg et al, , 2015cSzanto et al, 2015), of which four (Delaney et al, 2012;Minzenberg et al, 2015aMinzenberg et al, , 2015bSzanto et al, 2015) included nonsuicidal individuals. Full-scale intelligence was assessed using two measures: the Wechsler Adult Intelligence Scale, Third Edition (WAIS-III), and the Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II).…”

Section: Intelligencementioning

confidence: 99%

“…Attention was measured in two studies (Minzenberg et al, 2015a(Minzenberg et al, , 2015b using one measure: the AX version of the Continuous Performance Task (AX-CPT). Negligible effect size differences were observed comparing attempters to ideators and ideators to nonsuicidal individuals.…”

Section: Attentionmentioning

confidence: 99%

“…For example, seven studies used an overlapping sample of older adults aged 60 or older while three studies (Minzenberg et al, 2015a(Minzenberg et al, , 2015b(Minzenberg et al, , 2015c) focused on young adults in their early to mid-twenties. For example, seven studies used an overlapping sample of older adults aged 60 or older while three studies (Minzenberg et al, 2015a(Minzenberg et al, , 2015b(Minzenberg et al, , 2015c) focused on young adults in their early to mid-twenties.…”

Section: Limitations Of Existing Literature and Its Interpretationmentioning

confidence: 99%

“…Fifth, sample characteristics varied greatly between the studies included. For example, seven studies used an overlapping sample of older adults aged 60 or older while three studies (Minzenberg et al, 2015a(Minzenberg et al, , 2015b(Minzenberg et al, , 2015c) focused on young adults in their early to mid-twenties. Given the changes in cognition that occur with normal aging (Craik & Bialystok, 2006), it is possible that the relationship of neurocognitive abilities to suicide ideation and suicide attempts might change over the course of the lifespan.…”

Section: Limitations Of Existing Literature and Its Interpretationmentioning

confidence: 99%

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Do neurocognitive abilities distinguish suicide attempters from suicide ideators? A systematic review of an emerging research area

Saffer

Klonsky

2018

Clin Psychol Sci Pract

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Recent findings suggest that neurocognitive deficits may hasten progression from suicidal thoughts to behavior. To test this proposition, we examined whether neurocognitive deficits distinguish individuals who have attempted suicide (attempters) from those who have considered suicide but never attempted (ideators).A comprehensive literature search yielded 14 studies comparing attempters to ideators on a range of neurocognitive abilities. In general, attempters and ideators scored comparably across neurocognitive abilities (median Hedges' g = À.18). An exception was a moderate difference for inhibition and decision making (median Hedges' g = À.50 and g = À.49, respectively). Results suggest that some neurocognitive abilities might help explain the transition from suicidal thoughts to suicide attempts. However, findings are regarded as suggestive, given the small number of studies, few cross-study examinations of neurocognitive domains, and variability in sample characteristics. Recommendations for future research are included. K E Y W O R D Sneurocognitive abilities, neurocognitive functioning, suicide, suicide prevention, suicide risk ---

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Section: Statistical Analysesmentioning

confidence: 99%

Section: Intelligencementioning

confidence: 99%

Section: Attentionmentioning

confidence: 99%

Section: Limitations Of Existing Literature and Its Interpretationmentioning

confidence: 99%

Section: Limitations Of Existing Literature and Its Interpretationmentioning

confidence: 99%

See 3 more Smart Citations

Do neurocognitive abilities distinguish suicide attempters from suicide ideators? A systematic review of an emerging research area

Saffer

Klonsky

2018

Clin Psychol Sci Pract

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Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

Overs

Roberts

Ridgway

et al. 2021

American J of Med Genetics Pt B

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Bipolar disorder (BD) is associated with a 20-30-fold increased suicide risk compared to the general population. First-degree relatives of BD patients show inflated rates of psychopathology including suicidal behaviors. As reliable biomarkers of suicide attempts (SA) are lacking, we examined associations between suicide-related polygenic risk scores (PRSs)-a quantitative index of genomic risk-and variability in brain structures implicated in SA. Participants (n = 206; aged 12-30 years) were unrelated individuals of European ancestry and comprised three groups: 41 BD cases, 96 BD relatives ("high risk"), and 69 controls. Genotyping employed PsychArray, followed by imputation. Three PRSs were computed using genome-wide association data for SA in BD (SA-in-BD), SA in major depressive disorder (SA-in-MDD) (Mullins et al.,

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Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts

Cheng,

Chen,

Zhang

et al. 2023

Eur Child Adolesc Psychiatry

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Converging evidence has revealed disturbances in the corticostriatolimic system are associated with suicidal behaviors in adults with major depressive disorder. However, the neurobiological mechanism that confers suicidal vulnerability in depressed adolescents is largely unknown. A total of 86 depressed adolescents with and without prior suicide attempts (SA) and 47 healthy controls underwent resting-state functional imaging (R-fMRI) scans. The dynamic amplitude of low-frequency fluctuations (dALFF) was measured using sliding window approach. We identified SA-related alterations in dALFF variability primarily in the left middle temporal gyrus, inferior frontal gyrus, middle frontal gyrus (MFG), superior frontal gyrus (SFG), right SFG, supplementary motor area (SMA) and insula in depressed adolescents. Notably, dALFF variability in the left MFG and SMA was higher in depressed adolescents with recurrent suicide attempts than in those with a single suicide attempt. Moreover, dALFF variability was capable of generating better diagnostic and prediction models for suicidality than static ALFF. Our findings suggest that alterations in brain dynamics in regions involved in emotional processing, decision-making and response inhibition are associated with an increased risk of suicidal behaviors in depressed adolescents. Furthermore, dALFF variability could serve as a sensitive biomarker for revealing the neurobiological mechanisms underlying suicidal vulnerability.

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Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders

Cited by 62 publications

References 54 publications

Do neurocognitive abilities distinguish suicide attempters from suicide ideators? A systematic review of an emerging research area

Do neurocognitive abilities distinguish suicide attempters from suicide ideators? A systematic review of an emerging research area

Effects of polygenic risk for suicide attempt and risky behavior on brain structure in young people with familial risk of bipolar disorder

Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts

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