Controllable preparation of thio-functionalized composite polysilsesquioxane microspheres in a microreaction system

Tang, Tianyao; Han, Chien‐Chung; Deng, Jian; Luo, Guangsheng

doi:10.1016/j.apt.2022.103578

Cited by 11 publications

(5 citation statements)

References 44 publications

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“…The microreactor can accurately control the micro-upgraded volume of fluid containing tiny particles in a highly integrated reaction environment. The efficiency of fluid mixing and separation is improved by adding plentiful types of main forces such as inflatable pressure, magnetism, and dielectric power into the microreactor [ 110 ], which is beneficial to the preparation and formation of tiny particles such as fluorescent microspheres and microcarrier droplets, to promote the further development of drug delivery and catalyst loading [ 111 , 112 ]. Compared with conventional biochemical reaction systems, a microreactor reaction system has the following advantages: (1) High efficiency.…”

Section: Microreactorsmentioning

confidence: 99%

Review on Microreactors for Photo-Electrocatalysis Artificial Photosynthesis Regeneration of Coenzymes

Liu,

Sun,

Yang

et al. 2024

Micromachines

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In recent years, with the outbreak of the global energy crisis, renewable solar energy has become a focal point of research. However, the utilization efficiency of natural photosynthesis (NPS) is only about 1%. Inspired by NPS, artificial photosynthesis (APS) was developed and utilized in applications such as the regeneration of coenzymes. APS for coenzyme regeneration can overcome the problem of high energy consumption in comparison to electrocatalytic methods. Microreactors represent a promising technology. Compared with the conventional system, it has the advantages of a large specific surface area, the fast diffusion of small molecules, and high efficiency. Introducing microreactors can lead to more efficient, economical, and environmentally friendly coenzyme regeneration in artificial photosynthesis. This review begins with a brief introduction of APS and microreactors, and then summarizes research on traditional electrocatalytic coenzyme regeneration, as well as photocatalytic and photo-electrocatalysis coenzyme regeneration by APS, all based on microreactors, and compares them with the corresponding conventional system. Finally, it looks forward to the promising prospects of this technology.

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Section: Microreactorsmentioning

confidence: 99%

Review on Microreactors for Photo-Electrocatalysis Artificial Photosynthesis Regeneration of Coenzymes

Liu,

Sun,

Yang

et al. 2024

Micromachines

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“…44 From the research carried out earlier, it is evident that the majority of work has been done by maintaining a linear type of flow path where the flow area in the microreactors was constant. 11,[13][14][15][16]28,[33][34][35]44 Recent research has explored various reaction processes such as gas-liquid reactions, 45 ionic liquid reactions, 46 micro-particle synthesis, 47 organic chemical synthesis, 48,49 and nanoparticle synthesis. [50][51][52][53] These studies have typically employed T-type, helical coiltype, and flow focusing-type geometric configurations.…”

Section: Introductionmentioning

confidence: 99%

Intensification of silver nanoparticle synthesis through continuous flow split and recombine microreactors

Ghosh,

Kumar,

Atta

2024

React. Chem. Eng.

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“…Kalný et al used the T-junction microchannel reactor to obtain uniform mono-dispersed phase separation droplets and realized microscopic and efficient mixing between solvents, resulting in a narrow crystal size distribution of the final products. Luo et al. , used a semi-continuous microreaction system to achieve controllable preparation of composite polysilsesquioxane microspheres. The improvement of micro-mixing efficiency and the construction of homogeneous phase separation droplets were critical in the spherical crystallization process by using different devices.…”

Section: Introductionmentioning

confidence: 99%

Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

Zhao

Xiao

et al. 2023

Ind. Eng. Chem. Res.

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Spherical drug particles prepared by the spherical crystallization technique can simultaneously improve the mobility of particles, mechanical properties, drug solubility and bioavailability, etc. However, high-efficient mixing of a solution and the formation of uniform bridging liquid droplets were crucial for accurate control of spherical crystallization processes. Herein, a novel membrane-assisted spherical crystallization (MASC) technology was proposed to produce monodisperse spherical agglomerates of ceftriaxone sodium. The poor solvent permeation rate of MASC was stabilized by adjusting the liquid flow velocity in the shell side and tube side. Uniform bridging liquid droplets constructed by a polytetrafluoroethylene hollow fiber membrane were observed in real time. A stable flow field and crystallization microenvironment were provided on the hollow fiber membrane surface. The crystal size distribution and the coefficient of variation of ceftriaxone sodium products were improved compared with those of conventional spherical crystallization (CSC) under the same stirring rate. The impurities of CSC products did not meet the requirements due to the degradation after 14 days’ acceleration experiment, while the one of MASC products still met the pharmacopoeia requirements after 30 days. This study provides a potential membrane-based technology for the enhancement of spherical crystallization of related drugs.

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Controllable preparation of thio-functionalized composite polysilsesquioxane microspheres in a microreaction system

Cited by 11 publications

References 44 publications

Review on Microreactors for Photo-Electrocatalysis Artificial Photosynthesis Regeneration of Coenzymes

Review on Microreactors for Photo-Electrocatalysis Artificial Photosynthesis Regeneration of Coenzymes

Intensification of silver nanoparticle synthesis through continuous flow split and recombine microreactors

Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization

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