Controlled-cortical impact reduces volitional forelimb strength in rats

Pruitt, David; Hays, Seth A.; Schmid, Ariel N.; Choua, Connie; Kim, Lily; Trieu, Jenny; Kilgard, Michael P.; Rennaker, Robert L.

doi:10.1016/j.brainres.2014.07.039

Cited by 11 publications

(29 citation statements)

References 26 publications

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“…1). 13,14 Training continued until each animal achieved a performance of 5 consecutive days in which average success rate exceeded 85%. Prior to injury, the mean success rate of all rats before injury was 92 -0.8% and 92 -0.6% in the VNS + Rehab and the Rehab groups, respectively ( Fig.…”

Section: Rats Were Trained On the Isometric Pull Taskmentioning

confidence: 99%

“…14 The apparatus consisted of an acrylic box (25.4 · 30.5 · 12.1 cm). The box contained a slot in the front right corner that rats could reach through to access the aluminum pull handle.…”

Section: Behavioral Apparatus and Softwarementioning

confidence: 99%

“…14 The total volume of white matter was calculated for each hemisphere, and the ratio was taken as the total volume of white matter in the lesioned hemisphere to the total volume of white matter in the unlesioned hemisphere. The volume of gray matter was similarly calculated, and a ratio of the lesioned to the unlesioned hemisphere was obtained.…”

Section: Histologymentioning

confidence: 99%

“…Shaping procedures were similar to those previously described. 13,14 Animals were trained to pull on the handle with 120g of force, and single reward pellets were dispensed following successful trials (45 mg dustless precision pellet, BioServ, Frenchtown, NJ). If rats did not receive 50 pellets per day, they were given 10 g of additional pellets after daily training sessions were completed.…”

Section: Behavioral Trainingmentioning

confidence: 99%

“…13,14 After training, rats received a controlledcortical impact (CCI) lesion to model TBI. Animals were returned to training one week after the lesion, and then received 5 weeks of rehabilitative training during which VNS was delivered paired with successful trials.…”

mentioning

confidence: 99%

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Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Pruitt

Schmid

Kim

et al. 2016

Journal of Neurotrauma

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127

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Traumatic Brain Injury (TBI) is one of the largest health problems in the United States, and affects nearly 2 million people every year. The effects of TBI, including weakness and loss of coordination, can be debilitating and last years after the initial injury. Recovery of motor function is often incomplete. We have developed a method using electrical stimulation of the vagus nerve paired with forelimb use by which we have demonstrated enhanced recovery from ischemic and hemorrhagic stroke. Here we have tested the hypothesis that vagus nerve stimulation (VNS) paired with physical rehabilitation could enhance functional recovery after TBI. We trained rats to pull on a handle to receive a food reward. Following training, they received a controlled-cortical impact (CCI) in the forelimb area of motor cortex opposite the trained forelimb, and were then randomized into two treatment groups. One group of animals received VNS paired with rehabilitative therapy, whereas another group received rehabilitative therapy without VNS. Following CCI, volitional forelimb strength and task success rate in all animals were significantly reduced. VNS paired with rehabilitative therapy over a period of 5 weeks significantly increased recovery of both forelimb strength and success rate on the isometric pull task compared with rehabilitative training without VNS. No significant improvement was observed in the Rehab group. Our findings indicate that VNS paired with rehabilitative therapy enhances functional motor recovery after TBI.

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Section: Rats Were Trained On the Isometric Pull Taskmentioning

confidence: 99%

Section: Behavioral Apparatus and Softwarementioning

confidence: 99%

Section: Histologymentioning

confidence: 99%

Section: Behavioral Trainingmentioning

confidence: 99%

mentioning

confidence: 99%

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Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Pruitt

Schmid

Kim

et al. 2016

Journal of Neurotrauma

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127

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Median and ulnar nerve injuries reduce volitional forelimb strength in rats

et al. 2017

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Introduction Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function after PNI. Methods We developed an automated behavioral assay that provides quantitative measurements of volitional forelimb strength in rats. Multiple forelimb PNI models involving the median and ulnar nerves were used to assess forelimb function for up to 13 weeks postinjury. Results Despite multiple weeks of task-oriented training following injury, rats exhibit significant reductions in multiple quantitative parameters of forelimb function, including maximal pull force and speed of force generation. Conclusions This study demonstrates that the isometric pull task is an effective method of evaluating forelimb function following PNI and may aid in development of therapeutic interventions to restore function.

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Cholinergic Protection in Ischemic Brain Injury

Uteshev

2017

Springer Series in Translational Stroke Research

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Controlled-cortical impact reduces volitional forelimb strength in rats

Cited by 11 publications

References 26 publications

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury

Median and ulnar nerve injuries reduce volitional forelimb strength in rats

Cholinergic Protection in Ischemic Brain Injury

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