Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels

Abstract

Chitosan -β-glycerophosphate hydrogels have been widely studied for biomedical applications in recent years. In the current study a Chitosan -β-glycerophosphate hydrogel was evaluated as a platform for sodium fluoride release in the gastrointestinal tract. For this purpose, microscopy observation, infrared spectroscopy, stability, rheology studies and in vitro release assays were carried out. The hydrogel was stable for at least 48 h when exposed to an aqueous media in a pH range from 4 to 7 and the release of sodium fluoride was controlled for more than 6 h.In vivo studies were carried out in order to evaluate the oral administration of sodium fluoride using the hydrogel in comparison to a water solution. Fluoride pharmacokinetic was similar when the drug was administered with both formulations. Nevertheless, fluoride absorption was greater when the drug was given with the hydrogel, and further, drug-related side effects were absents. These results suggest that Chitosan -β-glycerophosphate hydrogel could be a good candidate for sustained release of fluoride in oral formulation.

Transdermal Sustained Release Properties and Anti‐Photoaging Efficacy of Liposome‐Thermosensitive Hydrogel System

“…[ 24 ] The characteristic peaks at 977 and 789 cm −1 in CMH2 hydrogel were attributed to the symmetric stretching and bending vibrations of the ‐PO 4 2− group in β‐GP, respectively. [ 32 ] The peaks of HA at 1617 and 1412 cm −1 correspond to the asymmetric and symmetric stretching vibrations of ─COOH. The peak of CMC2 spectrum at 1594 cm −1 was associated with ─COO − asymmetric stretching vibration and ‐NH 2 bending vibrations and shifted to 1573 cm −1 after the gel formation (CMH2).…”

“…[ 18 ] This could be due to the electrostatic attraction between the protonated amino group of CMC2 and the phosphate group of β‐GP, as well as the hydrogen bonding with the carboxyl group in the HA molecule (HA‐COO⋯NH 2 ‐CMC). [ 3,32 ]…”

“…[18] This could be due to the electrostatic attraction between the protonated amino group of CMC2 and the phosphate group of 𝛽-GP, as well as the hydrogen bonding with the carboxyl group in the HA molecule (HA-COO⋯NH 2 -CMC). [3,32] Anilinonaphthalene-8-sulfonic acid ammonium salt (ANS) fluorescence is commonly used to detect change in hydrophobicity during gelation. [33] Due to dynamic collision quenching, the fluorescence of ANS is quenched in the water medium, but the fluorescence is enhanced when trapped in the hydrophobic cavity.…”

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastroretentive Drug Delivery System

“…CH, a bioadhesive polysaccharide, is produced by the deacetylation of chitin in the presence of an alkaline substance such as sodium hydroxide (30). This polymer has been extensively studied as a drug delivery system due to its unique properties such as high bioadhesivity, proper viscosity, good molding ability, non-toxicity, low cost, excellent biocompatibility, bioactivity, and biodegradability (31)(32)(33)(34)(35)(36). Due to the presence of many amine groups on its polymeric chains, CH can form spherical hydrogel compounds via cross-linking with multivalent anions such as tripolyphosphate (TPP) ions (31).…”

The Synthesis, Characterization, and Protein-Release Properties of Hydrogels Composed of Chitosan-Zingiber offcinale Polysaccharide

“…CS is the only cationic polysaccharide in nature [ 13 ], which is non-toxic and easy to degrade. It is often used to prepare materials such as hydrogels [ 14 ].…”