Controlled mechanical ventilation in horses under vecuronium blockage

Effect of pressure support ventilation during weaning on ventilation and oxygenation indices in healthy horses recovering from general anesthesia

“…In CG, weaning resulted in mild and transient hypoventilation and respiratory acidosis but most of the ventilatory values were within the normal range, and results were similar to data observed by other authors who weaned horses with a similar method (Fantoni et al. ; Klemm et al. ; Bechara et al.…”

“…The recovery of spontaneous breathing is commonly performed by induced hypercapnia and respiratory acidosis to stimulate the respiratory center (Fantoni et al. ; Klemm et al. ; Wright & Hildebrand ; Santos et al.…”

Observations of the potency and duration of vecuronium in isoflurane-anesthetized horses

“…Our results pertaining to the duration of action of VEC differ markedly from those obtained by Fantoni and collaborators (Fantoni et al. 1998), in which 100 μg kg −1 VEC produced incomplete blockade in horses, but the duration of action was determined to be only ∼ 12 minutes.…”

“…Although this drug has been used in horses (Klein et al. 1982; Fantoni et al. 1998), to our knowledge the ED50, ED90, pharmacokinetic and pharmacodynamic parameters of vecuronium have not been reported in this species.…”