Controlled Porosity Solubility Modulated Osmotic Pump Tablets of Gliclazide

Banerjee, Arti; Verma, Priya Ranjan Prasad; Gore, Subhash

doi:10.1208/s12249-014-0246-0

Cited by 23 publications

(19 citation statements)

References 41 publications

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“…This may be due to the reduced surface/mass ratio of the larger tablets. As drug release from polymeric matrix is mainly governed by erosion and diffusion mechanism [37][38][39], a slower release was expected due to the smaller surface area/mass ratio.…”

Section: Resultsmentioning

confidence: 99%

Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets

Sadia

Arafat

Ahmed

et al. 2018

Journal of Controlled Release

306

151

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Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling (FDM) 3D printing technique has a considerable potential for patient-specific dosage forms. However, the use of FDM 3D printing in tablet manufacturing requires a large portion of polymer, which slows down drug release through erosion and diffusion mechanisms. In this study, we demonstrate for the first time the use of a novel design approach of caplets with perforated channels to accelerate drug release from 3D printed tablets. This strategy has been implemented using a caplet design with perforating channels of increasing width (0.2, 0.4, 0.6, 0.8 or 1.0mm) and variable length, and alignment (parallel or at right angle to tablet long axis). Hydrochlorothiazide (BCS class IV drug) was chosen as the model drug as enhanced dissolution rate is vital to guarantee oral bioavailability. The inclusion of channels exhibited an increase in the surface area/volume ratio, however, the release pattern was also influenced by the width and the length of the channel. A channel width was ≥0.6mm deemed critical to meet the USP criteria of immediate release products. Shorter multiple channels (8.6mm) were more efficient at accelerating drug release than longer channels (18.2mm) despite having comparable surface area/mass ratio. This behaviour may be linked to the reduced flow resistance within the channels and the faster fragmentation during dissolution of these tablets. In conclusion, the width and length of the channel should be carefully considered in addition to surface area/mass when optimizing drug release from 3D printed designs. The incorporation of short channels can be adopted in the designs of dosage forms, implants or stents to enhance the release rate of eluting drug from polymer-rich structures.

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Section: Resultsmentioning

confidence: 99%

Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets

Sadia

Arafat

Ahmed

et al. 2018

Journal of Controlled Release

306

151

View full text Add to dashboard Cite

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“…Phase solubility studies of Garcinia indica extract with different concentrations of hydroxypropyl-betacyclodextrin (HP-ß-CD) were performed according to the method described by Higuchi and Connors to determine stoichiometric proportions of extract with HPß-CD [9][10] . The data were used to determine stability constant of the complexes.…”

Section: Methods: Phase Solubility Analysis For Garcinia Indica Extractmentioning

confidence: 99%

Design and Development of Controlled Porosity Osmotic Tablets of Garcinia Indica Extract

Jagtap¹,

Prakya

Bhise

2018

J. Drug Delivery Ther.

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The present study deals with the development and evaluation of controlled porosity osmotic pump (CPOP) tablets containing inclusion complexes of methanolic extract of Garcinia indica fruit rind. Wet granulation method was used for the development of core tablets. Core tablets were incorporated with different concentrations of sodium chloride as osmogen and additives. The CPOP tablets were coated with cellulose acetate as a wall forming material and HPMC acts as pore forming material in SPM. The formulated tablets were evaluated for FTIR, DSC, pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. The optimized formulation had no significant effect on the pH and agitation intensity. SEM images revealed that no pores were found before dissolution and after dissolution had shown the porous nature of the membrane. It was found that the optimized formulation (P4) delivers a drug at a zero-order rate for 12 hours. Short term stability study at 40±2ºC /75±5% RH for the months on the optimized formulation indicated that there was no significant change in weight variation, % friability, drug content and in vitro drug release.

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“…SPM for various batches were prepared by taking different concentrations of pore former 15 . The effect of pore former on in vitro release profile is compared as well as number of formation of micropores were observed.…”

Section: Effect Of Pore Former Concentrationmentioning

confidence: 99%

Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablets for Zidovudine and Lamivudine Combination Using Fructose as Osmogen

Sahoo

Rao

Sudhakar³

2017

J. Drug Delivery Ther.

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The present study deals with the development and evaluation of controlled porosity osmotic pump (CPOP) tablets of Zidovudine-Lamivudine. Wet granulation method was used for the development of core tablets. Core tablets were incorporated with HPMCE5 LV polymer, different concentrations of fructose as osmogen and additives. The CPOP tablets were coated with cellulose acetate as a wall forming material, polyethylene glycol as flux regulating agent, and sorbitol acts as pore forming material in SPM. The formulated tablets were evaluated for FTIR, DSC, pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. The optimized formulation had no significant effect on the p H and agitation intensity, but depends on the osmotic pressure of dissolution media indicated that mechanism of drug release. SEM images revealed that no pores were found before dissolution and after dissolution had shown the porous nature of the membrane. Short term stability study at 40±2ºC /75±5% RH for the months on the CF4 formulation indicated that there was no significant change weight variation, % friability, drug content and in vitro drug release. Cite this article as:Sahoo CK, Rao SRM, Sudhakar M, Formulation and evaluation of controlled porosity osmotic pump tablets for Zidovudine and Lamivudine combination using fructose as osmogen, Journal of Drug Delivery and Therapeutics. 2017; 7(4):41-50

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Controlled Porosity Solubility Modulated Osmotic Pump Tablets of Gliclazide

Cited by 23 publications

References 41 publications

Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets

Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets

Design and Development of Controlled Porosity Osmotic Tablets of Garcinia Indica Extract

Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablets for Zidovudine and Lamivudine Combination Using Fructose as Osmogen

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